The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitus - Kasichayanula, Sreeneeranj; Liu, Xiaoni; Pe Benito, Melanie; Yao, Ming; Pfister, Marc; LaCreta, Frank P.; Humphreys, William Griffith; Boulton, David W. (British journal of clinical pharmacology, 2013)
Keywords: Adolescent; Adult; Aged; Benzhydryl Compounds; Blood Glucose - analysis; dapagliflozin; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - urine; Dose-Response Relationship, Drug; Female; Glucosides - adverse effects; Glucosides - pharmacokinetics; Glucosides - pharmacology; Glucosides - therapeutic use; glucuronosyltransferase; Glycosuria - urine; Humans; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - pharmacokinetics; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Kidney - drug effects; Kidney - metabolism; Kidney - physiopathology; Kidney Function Tests; Liver - drug effects; Liver - metabolism; Liver - physiopathology; Male; Middle Aged; Pharmacokinetic Dynamic Relationships; renal insufficiency; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; type 2 diabetes mellitus; UGT1A9; Young Adult; sodium-glucose transporter 2; type 2 diabetes mellitus; glucuronosyltransferase; UGT1A9; dapagliflozin; renal insufficiency