Lithium concentration and recurrence risk during maintenance treatment of bipolar disorder: Multicenter cohort and meta‐analysis

• Published in: Acta psychiatrica Scandinavica Vol. 144; no. 4; pp. 368 - 378
• Main Authors: Hsu, Chih‐Wei, Carvalho, Andre F., Tsai, Shang‐Ying, Wang, Liang‐Jen, Tseng, Ping‐Tao, Lin, Pao‐Yen, Tu, Yu‐Kang, Vieta, Eduard, Solmi, Marco, Hung, Chi‐Fa, Kao, Hung‐Yu
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2021; John Wiley and Sons Inc
• Subjects: Antimanic Agents - therapeutic use; Bipolar disorder; Bipolar Disorder - drug therapy; Bipolar Disorder - epidemiology; Cohort Studies; dose‐response meta‐analysis; Drug dosages; Humans; Lithium; Lithium - therapeutic use; maintenance treatment; Meta-analysis; Mood; Original; Recurrence; Retrospective Studies; Risk; serum level; Serum levels; serum level; dose-response meta-analysis; lithium; bipolar disorder; maintenance treatment

Objective To compare differences in efficacy during maintenance treatment for bipolar disorder (BD) according to lithium serum levels. A multicenter retrospective cohort study and a dose‐response meta‐analysis were conducted. Methods The cohort study was conducted in Taiwan from 2001 to 2019 to iden...