Unraveling the MRI‐Based Microstructural Signatures Behind Primary Progressive and Relapsing–Remitting Multiple Sclerosis Phenotypes

• Published in: Journal of magnetic resonance imaging Vol. 55; no. 1; pp. 154 - 163
• Main Authors: Boscolo Galazzo, Ilaria, Brusini, Lorenza, Akinci, Muge, Cruciani, Federica, Pitteri, Marco, Ziccardi, Stefano, Bajrami, Albulena, Castellaro, Marco, Salih, Ahmed M.A., Pizzini, Francesca B., Jovicich, Jorge, Calabrese, Massimiliano, Menegaz, Gloria
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2022; Wiley Subscription Services, Inc
• Subjects: 3D‐SHORE; Cross-Sectional Studies; Degeneration; diffusion MRI; Diffusion Tensor Imaging; EDSS; Feature extraction; Females; Field strength; gray matter; Hippocampus; Humans; Image reconstruction; Magnetic Resonance Imaging; Medical imaging; Microstructure; morphometry; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging; Phenotype; Phenotypes; Prospective Studies; Statistical analysis; Statistical tests; Substantia grisea; Support vector machines; SVM; Tensors; Thalamus; 3D-SHORE; diffusion MRI; morphometry; SVM; gray matter; EDSS

Background The mechanisms driving primary progressive and relapsing–remitting multiple sclerosis (PPMS/RRMS) phenotypes are unknown. Magnetic resonance imaging (MRI) studies support the involvement of gray matter (GM) in the degeneration, highlighting its damage as an early feature of both phenotype...