Effects of TH1 and TH2 Cytokines on CD8+Cell Response Against Human Immunodeficiency Virus: Implications for Long-Term Survival

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 92; no. 24; pp. 11135 - 11139
• Main Authors: Barker, Edward, Mackewicz, Carl E., Levy, Jay A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 21.11.1995; National Acad Sciences
• Subjects: AIDS; AIDS/HIV; Antivirals; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Cells, Cultured; Cultured cells; Cytokines; Cytokines - physiology; Disease Progression; HIV; HIV infections; HIV Infections - immunology; HIV-1 - growth & development; HIV-1 - immunology; Humans; Immunity, Cellular; Infections; Interleukin-10 - physiology; Interleukin-2 - biosynthesis; Interleukin-4 - physiology; Interleukins; T lymphocytes; Th1 Cells - physiology; Th2 Cells - physiology; Time Factors; Virus Replication

CD8+cells from long-term survivors [LTS; infected with human immunodeficiency virus (HIV) for 10 or more years and having CD4+cell counts of ≥500 cells per μl] have a 3-fold greater ability to suppress HIV replication than do CD8+cells from patients who have progressed to disease (progressors) durin...