Single‐nucleus transcriptome analysis reveals disease‐ and regeneration‐associated endothelial cells in white matter vascular dementia

• Published in: Journal of cellular and molecular medicine Vol. 26; no. 11; pp. 3183 - 3195
• Main Authors: Mitroi, Daniel N., Tian, Min, Kawaguchi, Riki, Lowry, William E., Carmichael, S. Thomas
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.06.2022; John Wiley and Sons Inc
• Subjects: Alzheimer's disease; Angiogenesis; Antibodies; Apoptosis; Axon sprouting; Brain; Brain - metabolism; Cell death; Dementia; Dementia disorders; Dementia, Vascular - genetics; Dementia, Vascular - pathology; disease‐associated endothelial cells; Endothelial cells; Endothelial Cells - metabolism; Gene expression; Gene Expression Profiling; Genomes; Genomics; Glial stem cells; Homogenization; Humans; Immune response; Ischemia; Myelination; Original; Progenitor cells; Protein folding; Regeneration; snRNA‐seq; Substantia alba; Transcriptomes; Transcriptomics; Vascular dementia; white matter; White Matter - metabolism; White Matter - pathology; disease-associated endothelial cells; white matter; angiogenesis; vascular dementia; snRNA-seq

Background Vascular dementia (VaD) is the accumulation of vascular lesions in the subcortical white matter of the brain. These lesions progress and there is no direct medical therapy. Aims To determine the specific cellular responses in VaD so as to provide molecular targets for therapeutic developm...