Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities

• Published in: Journal of peptide science Vol. 18; no. 8; pp. 500 - 510
• Main Authors: Ayers, Sloan, Ehrmann, Brandie M., Adcock, Audrey F., Kroll, David J., Carcache de Blanco, Esperanza J., Shen, Qi, Swanson, Steven M., Falkinham III, Joseph O., Wani, Mansukh C., Mitchell, Sheila M., Pearce, Cedric J., Oberlies, Nicholas H.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.08.2012
• Subjects: Animals; anthelmintic; Anthelmintics - chemistry; Anthelmintics - pharmacology; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; cytotoxicity; Haemonchus - drug effects; higher-energy collisional dissociation (HCD); Humans; Hypocreales; Hypocreales - chemistry; Membrane Potential, Mitochondrial - drug effects; Methicillin-Resistant Staphylococcus aureus - drug effects; Nuclear Magnetic Resonance, Biomolecular; peptaibols; Peptaibols - chemistry; Peptaibols - pharmacology

As part of an ongoing investigation of filamentous fungi for anticancer leads, an active culture was identified from the Mycosynthetix library (MSX 70741, of the order Hypocreales, Ascomycota). The fungal extract exhibited cytotoxic activity against the H460 (human nonsmall cell lung carcinoma) cell...