Exploring blood microbial communities and their influence on human cardiovascular disease

Background Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating micr...

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Published inJournal of clinical laboratory analysis Vol. 36; no. 4; pp. e24354 - n/a
Main Authors Khan, Ikram, Khan, Imran, Jianye, Zhou, Xiaohua, Zhang, Khan, Murad, Hilal, Mian Gul, Kakakhel, Mian Adnan, Mehmood, Arshad, Lizhe, An, Zhiqiang, Li
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.04.2022
John Wiley and Sons Inc
Subjects
Actinobacteria
Alzheimer's disease
Anthrax
Arteriosclerosis
Bacteria
bacterial translocation
Blood
blood circulation
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cattle
Cerebral infarction
Cholesterol
Congestive heart failure
Coronary artery disease
Diabetes
Dysbacteriosis
Dysbiosis - microbiology
Heart
Humans
Hyperactivity
Hyperlipidemia
Infectious diseases
Inflammatory diseases
Investigations
Lipopolysaccharides
Metabolism
Metabolites
Microbiomes
Microbiota
Microorganisms
Myocardial Infarction
noncommunicable diseases
Nucleotide sequence
Proteobacteria
Review
Risk factors
Stroke
Vein & artery diseases
United States > US
blood circulation
bacterial translocation
cardiovascular diseases
noncommunicable diseases
bacteria
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Abstract Background Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating microbiome or the blood microbiome has been analyzed recently in chronic inflammatory diseases, including CVD in humans. Methods For this review, all relevant original research studies were assessed by searching in electronic databases, including PubMed, Google Scholar, and Web of Science, by using relevant keywords. Results This review demonstrated that elevated markers of systemic bacterial exposure are associated with noncommunicable diseases, including CVD. Studies have shown that the bacterial DNA sequence found in healthy blood belongs mainly to the Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla. In cardiac events, such as stroke, coronary heart disease, and myocardial infarction, the increased proportion of Proteobacteria and Actinobacteria phyla was found. Lipopolysaccharides are a major component of Proteobacteria, which play a key role in the onset of CVD. Moreover, recently, a study reported the lower cholesterol‐degrading bacteria, including Caulobacterales order and Caulobacteraceae family were both considerably reduced in myocardial infarction. Conclusion Proteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD. In this study, we highlight the origin of the blood microbiota, alteration in the blood microbial makeup, and their association with the etiology and progression of cardiovascular disease.
AbstractList Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating microbiome or the blood microbiome has been analyzed recently in chronic inflammatory diseases, including CVD in humans.BACKGROUNDCardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating microbiome or the blood microbiome has been analyzed recently in chronic inflammatory diseases, including CVD in humans.For this review, all relevant original research studies were assessed by searching in electronic databases, including PubMed, Google Scholar, and Web of Science, by using relevant keywords.METHODSFor this review, all relevant original research studies were assessed by searching in electronic databases, including PubMed, Google Scholar, and Web of Science, by using relevant keywords.This review demonstrated that elevated markers of systemic bacterial exposure are associated with noncommunicable diseases, including CVD. Studies have shown that the bacterial DNA sequence found in healthy blood belongs mainly to the Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla. In cardiac events, such as stroke, coronary heart disease, and myocardial infarction, the increased proportion of Proteobacteria and Actinobacteria phyla was found. Lipopolysaccharides are a major component of Proteobacteria, which play a key role in the onset of CVD. Moreover, recently, a study reported the lower cholesterol-degrading bacteria, including Caulobacterales order and Caulobacteraceae family were both considerably reduced in myocardial infarction.RESULTSThis review demonstrated that elevated markers of systemic bacterial exposure are associated with noncommunicable diseases, including CVD. Studies have shown that the bacterial DNA sequence found in healthy blood belongs mainly to the Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla. In cardiac events, such as stroke, coronary heart disease, and myocardial infarction, the increased proportion of Proteobacteria and Actinobacteria phyla was found. Lipopolysaccharides are a major component of Proteobacteria, which play a key role in the onset of CVD. Moreover, recently, a study reported the lower cholesterol-degrading bacteria, including Caulobacterales order and Caulobacteraceae family were both considerably reduced in myocardial infarction.Proteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD.CONCLUSIONProteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD.
In this study, we highlight the origin of the blood microbiota, alteration in the blood microbial makeup, and their association with the etiology and progression of cardiovascular disease.
Background Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating microbiome or the blood microbiome has been analyzed recently in chronic inflammatory diseases, including CVD in humans. Methods For this review, all relevant original research studies were assessed by searching in electronic databases, including PubMed, Google Scholar, and Web of Science, by using relevant keywords. Results This review demonstrated that elevated markers of systemic bacterial exposure are associated with noncommunicable diseases, including CVD. Studies have shown that the bacterial DNA sequence found in healthy blood belongs mainly to the Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla. In cardiac events, such as stroke, coronary heart disease, and myocardial infarction, the increased proportion of Proteobacteria and Actinobacteria phyla was found. Lipopolysaccharides are a major component of Proteobacteria, which play a key role in the onset of CVD. Moreover, recently, a study reported the lower cholesterol‐degrading bacteria, including Caulobacterales order and Caulobacteraceae family were both considerably reduced in myocardial infarction. Conclusion Proteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD. In this study, we highlight the origin of the blood microbiota, alteration in the blood microbial makeup, and their association with the etiology and progression of cardiovascular disease.
Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating microbiome or the blood microbiome has been analyzed recently in chronic inflammatory diseases, including CVD in humans. For this review, all relevant original research studies were assessed by searching in electronic databases, including PubMed, Google Scholar, and Web of Science, by using relevant keywords. This review demonstrated that elevated markers of systemic bacterial exposure are associated with noncommunicable diseases, including CVD. Studies have shown that the bacterial DNA sequence found in healthy blood belongs mainly to the Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla. In cardiac events, such as stroke, coronary heart disease, and myocardial infarction, the increased proportion of Proteobacteria and Actinobacteria phyla was found. Lipopolysaccharides are a major component of Proteobacteria, which play a key role in the onset of CVD. Moreover, recently, a study reported the lower cholesterol-degrading bacteria, including Caulobacterales order and Caulobacteraceae family were both considerably reduced in myocardial infarction. Proteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD.
BackgroundCardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating microbiome or the blood microbiome has been analyzed recently in chronic inflammatory diseases, including CVD in humans.MethodsFor this review, all relevant original research studies were assessed by searching in electronic databases, including PubMed, Google Scholar, and Web of Science, by using relevant keywords.ResultsThis review demonstrated that elevated markers of systemic bacterial exposure are associated with noncommunicable diseases, including CVD. Studies have shown that the bacterial DNA sequence found in healthy blood belongs mainly to the Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla. In cardiac events, such as stroke, coronary heart disease, and myocardial infarction, the increased proportion of Proteobacteria and Actinobacteria phyla was found. Lipopolysaccharides are a major component of Proteobacteria, which play a key role in the onset of CVD. Moreover, recently, a study reported the lower cholesterol‐degrading bacteria, including Caulobacterales order and Caulobacteraceae family were both considerably reduced in myocardial infarction.ConclusionProteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD.
Author Kakakhel, Mian Adnan
Xiaohua, Zhang
Zhiqiang, Li
Khan, Ikram
Khan, Imran
Jianye, Zhou
Hilal, Mian Gul
Mehmood, Arshad
Khan, Murad
Lizhe, An
AuthorAffiliation 5 71213 Department of Neurology The Second Hospital of Hebei Medical University Shijiazhuang China
3 66293 Key Laboratory of Oral Diseases of Gansu Province School of Stomatology Northwest Minzu University Lanzhou China
4 12553 Department of Genetics Hebei Key Laboratory Animal Hebei Medical University Shijiazhuang China
2 Department of Microbiology Khyber Medical University Peshawar Peshawar Pakistan
1 12426 School of Life Sciences Lanzhou University Lanzhou China
AuthorAffiliation_xml – name: 1 12426 School of Life Sciences Lanzhou University Lanzhou China
– name: 5 71213 Department of Neurology The Second Hospital of Hebei Medical University Shijiazhuang China
– name: 3 66293 Key Laboratory of Oral Diseases of Gansu Province School of Stomatology Northwest Minzu University Lanzhou China
– name: 2 Department of Microbiology Khyber Medical University Peshawar Peshawar Pakistan
– name: 4 12553 Department of Genetics Hebei Key Laboratory Animal Hebei Medical University Shijiazhuang China
Author_xml – sequence: 1
  givenname: Ikram
  surname: Khan
  fullname: Khan, Ikram
  organization: Lanzhou University
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  organization: Khyber Medical University Peshawar
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  surname: Jianye
  fullname: Jianye, Zhou
  organization: Northwest Minzu University
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  givenname: Zhang
  surname: Xiaohua
  fullname: Xiaohua, Zhang
  organization: Northwest Minzu University
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  fullname: Khan, Murad
  organization: Hebei Medical University
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  surname: Hilal
  fullname: Hilal, Mian Gul
  organization: Lanzhou University
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  givenname: Mian Adnan
  surname: Kakakhel
  fullname: Kakakhel, Mian Adnan
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  organization: The Second Hospital of Hebei Medical University
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  givenname: An
  surname: Lizhe
  fullname: Lizhe, An
  email: yxlzq@xbmu.edu.cn
  organization: Lanzhou University
– sequence: 10
  givenname: Li
  surname: Zhiqiang
  fullname: Zhiqiang, Li
  email: lizhiqiang6767@163.com
  organization: Northwest Minzu University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35293034$$D View this record in MEDLINE/PubMed
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1098-2825
IngestDate Thu Aug 21 18:21:58 EDT 2025
Fri Jul 11 00:33:04 EDT 2025
Wed Aug 13 09:40:38 EDT 2025
Wed Feb 19 02:27:14 EST 2025
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Thu Apr 24 23:06:45 EDT 2025
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Issue 4
Keywords blood circulation
bacterial translocation
cardiovascular diseases
noncommunicable diseases
bacteria
Language English
License Attribution
2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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MergedId FETCHMERGED-LOGICAL-c4484-e6ddf3c8569f02153a9e8439a6b4530bbcdfe5f662f0273942304bb4b0a0c1ac3
Notes Funding information
This work was supported by the National Natural Science Foundation of China (31760159).
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Snippet Background Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis,...
Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis,...
BackgroundCardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis,...
In this study, we highlight the origin of the blood microbiota, alteration in the blood microbial makeup, and their association with the etiology and...
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StartPage e24354
SubjectTerms Actinobacteria
Alzheimer's disease
Anthrax
Arteriosclerosis
Bacteria
bacterial translocation
Blood
blood circulation
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cattle
Cerebral infarction
Cholesterol
Congestive heart failure
Coronary artery disease
Diabetes
Dysbacteriosis
Dysbiosis - microbiology
Heart
Humans
Hyperactivity
Hyperlipidemia
Infectious diseases
Inflammatory diseases
Investigations
Lipopolysaccharides
Metabolism
Metabolites
Microbiomes
Microbiota
Microorganisms
Myocardial Infarction
noncommunicable diseases
Nucleotide sequence
Proteobacteria
Review
Risk factors
Stroke
Vein & artery diseases
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Title Exploring blood microbial communities and their influence on human cardiovascular disease
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcla.24354
https://www.ncbi.nlm.nih.gov/pubmed/35293034
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Volume 36
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