Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease

• Published in: Advanced materials (Weinheim) Vol. 24; no. 13; pp. 1722 - 1728
• Main Authors: Li, Meng, Yang, Xinjian, Ren, Jinsong, Qu, Konggang, Qu, Xiaogang
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 03.04.2012; WILEY‐VCH Verlag
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - therapy; Alzheimer's disease; amyloid; Amyloid - metabolism; Animals; Cell Survival - drug effects; graphene; Graphite - chemistry; Graphite - pharmacology; Graphite - therapeutic use; Humans; Hyperthermia, Induced - methods; Mice; nanomaterials; Nanostructures - chemistry; Oxides - chemistry; Oxides - pharmacology; Oxides - therapeutic use; PC12 Cells; phototherapy; Phototherapy - methods; Rats; Thiazoles - chemistry; Thiazoles - pharmacology; Thiazoles - therapeutic use

A novel strategy to dissociate amyloid aggregation is presented, using localised heat generation from a clinically used amyloid staining dye, thioflavin‐S (ThS)‐modified graphene oxide (GO) under NIR laser irradiation. Compared to traditional chemotherapies, photothermal therapy shows reduced side e...