Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease

A novel strategy to dissociate amyloid aggregation is presented, using localised heat generation from a clinically used amyloid staining dye, thioflavin‐S (ThS)‐modified graphene oxide (GO) under NIR laser irradiation. Compared to traditional chemotherapies, photothermal therapy shows reduced side e...

Full description

Saved in:
Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 24; no. 13; pp. 1722 - 1728
Main Authors Li, Meng, Yang, Xinjian, Ren, Jinsong, Qu, Konggang, Qu, Xiaogang
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 03.04.2012
WILEY‐VCH Verlag
Subjects
Alzheimer Disease - metabolism
Alzheimer Disease - therapy
Alzheimer's disease
amyloid
Amyloid - metabolism
Animals
Cell Survival - drug effects
graphene
Graphite - chemistry
Graphite - pharmacology
Graphite - therapeutic use
Humans
Hyperthermia, Induced - methods
Mice
nanomaterials
Nanostructures - chemistry
Oxides - chemistry
Oxides - pharmacology
Oxides - therapeutic use
PC12 Cells
phototherapy
Phototherapy - methods
Rats
Thiazoles - chemistry
Thiazoles - pharmacology
Thiazoles - therapeutic use
Online AccessGet full text

Cover

More Information
Summary:A novel strategy to dissociate amyloid aggregation is presented, using localised heat generation from a clinically used amyloid staining dye, thioflavin‐S (ThS)‐modified graphene oxide (GO) under NIR laser irradiation. Compared to traditional chemotherapies, photothermal therapy shows reduced side effects and improved selectivity and safety.
Bibliography:istex:E880AC9894E3FB54E0814408F55874317A0E9E71
ark:/67375/WNG-CBFBJ2QB-4
ArticleID:ADMA201104864
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.201104864