Detection of viral DNA sequences in the cerebrospinal fluid of patients with multiple sclerosis

• Published in: Journal of medical virology Vol. 82; no. 6; pp. 1051 - 1057
• Main Authors: Mancuso, Roberta, Hernis, Ambra, Cavarretta, Rosella, Caputo, Domenico, Calabrese, Elena, Nemni, Raffaello, Ferrante, Pasquale, Delbue, Serena, Clerici, Mario
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2010; Wiley
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; cerebrospinal fluid; Cerebrospinal Fluid - virology; DNA, Viral - genetics; DNA, Viral - isolation & purification; EBV; Female; Fundamental and applied biological sciences. Psychology; Herpesvirus 3, Human - genetics; Herpesvirus 4, Human - genetics; Herpesvirus 6, Human - genetics; HHV-6; Human viral diseases; Humans; Infectious diseases; JC Virus - genetics; JCV; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; multiple sclerosis; Multiple Sclerosis - virology; Viral diseases; Virology; VZV; Young Adult; Gammaherpesvirinae; Human; Nervous system diseases; Multiple sclerosis; Nucleotide sequence; Herpesviridae; HHV-6; Epstein Barr virus; Cerebrospinal fluid; Inflammatory disease; Virus; VZV; Central nervous system disease; EBV; Detection; Human herpesvirus 6; JCV

The role of viruses in the pathogenesis of multiple sclerosis (MS) is a subject of heated debate. The presence of six different neurotropic viruses was sought, including JC virus (JCV), varicella zoster virus (VZV), human herpesvirus 6 (HHV-6), and Epstein-Barr virus (EBV), in cerebrospinal fluid (C...