Two Novel Steroidal Alkaloid Glycosides from the Seeds of Lycium barbarum

• Published in: Chemistry & biodiversity Vol. 8; no. 12; pp. 2277 - 2284
• Main Authors: Wang, Kun, Sasaki, Tatsunori, Li, Wei, Li, Qin, Wang, Yinghua, Asada, Yoshihisa, Kato, Hiroyoshi, Koike, Kazuo
• Format: Journal Article
• Language: English
• Published: Zürich WILEY-VCH Verlag 01.12.2011; WILEY‐VCH Verlag
• Subjects: Alkaloids; Alkaloids - chemistry; Alkaloids - isolation & purification; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Glycoside Hydrolase Inhibitors; Glycosides; Glycosides - chemistry; Glycosides - isolation & purification; Inhibitors; Intestines - chemistry; Intestines - drug effects; Intestines - enzymology; Lyciosides A and B; Lycium - chemistry; Lycium barbarum; Medicine, Chinese Traditional; Molecular Structure; Phytosterols - chemistry; Phytosterols - isolation & purification; Rats; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology; Seeds - chemistry; Steroids; Sucrase - antagonists & inhibitors
• ISSN: 1612-1872; 1612-1880; 1612-1880
• DOI: 10.1002/cbdv.201000293

Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC50 values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and 59.1 μM against rat intestinal maltase.