Two Novel Steroidal Alkaloid Glycosides from the Seeds of Lycium barbarum

Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC50 values of 75.3 and 72.8 μM against rat intest...

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Published inChemistry & biodiversity Vol. 8; no. 12; pp. 2277 - 2284
Main Authors Wang, Kun, Sasaki, Tatsunori, Li, Wei, Li, Qin, Wang, Yinghua, Asada, Yoshihisa, Kato, Hiroyoshi, Koike, Kazuo
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.12.2011
WILEY‐VCH Verlag
Subjects
Alkaloids
Alkaloids - chemistry
Alkaloids - isolation & purification
Animals
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Glycoside Hydrolase Inhibitors
Glycosides
Glycosides - chemistry
Glycosides - isolation & purification
Inhibitors
Intestines - chemistry
Intestines - drug effects
Intestines - enzymology
Lyciosides A and B
Lycium - chemistry
Lycium barbarum
Medicine, Chinese Traditional
Molecular Structure
Phytosterols - chemistry
Phytosterols - isolation & purification
Rats
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
Seeds - chemistry
Steroids
Sucrase - antagonists & inhibitors
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Abstract Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC50 values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and 59.1 μM against rat intestinal maltase.
AbstractList Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC(50) values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and 59.1 μM against rat intestinal maltase.Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC(50) values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and 59.1 μM against rat intestinal maltase.
Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC(50) values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and 59.1 μM against rat intestinal maltase.
Two novel steroidal alkaloid glycosides, lycioside A ( 1 ) and lycioside B ( 2 ) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC 50 values of 75.3 and 72.8 μ M against rat intestinal sucrase, and 63.4 and 59.1 μ M against rat intestinal maltase.
Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC50 values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and 59.1 μM against rat intestinal maltase.
Author Wang, Yinghua
Asada, Yoshihisa
Li, Qin
Kato, Hiroyoshi
Li, Wei
Sasaki, Tatsunori
Koike, Kazuo
Wang, Kun
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Snippet Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined...
Two novel steroidal alkaloid glycosides, lycioside A ( 1 ) and lycioside B ( 2 ) were isolated from the seeds of Lycium barbarum. Their structures were...
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SubjectTerms Alkaloids
Alkaloids - chemistry
Alkaloids - isolation & purification
Animals
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Glycoside Hydrolase Inhibitors
Glycosides
Glycosides - chemistry
Glycosides - isolation & purification
Inhibitors
Intestines - chemistry
Intestines - drug effects
Intestines - enzymology
Lyciosides A and B
Lycium - chemistry
Lycium barbarum
Medicine, Chinese Traditional
Molecular Structure
Phytosterols - chemistry
Phytosterols - isolation & purification
Rats
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
Seeds - chemistry
Steroids
Sucrase - antagonists & inhibitors
Title Two Novel Steroidal Alkaloid Glycosides from the Seeds of Lycium barbarum
URI https://api.istex.fr/ark:/67375/WNG-9PF7F0TZ-D/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcbdv.201000293
https://www.ncbi.nlm.nih.gov/pubmed/22162165
https://www.proquest.com/docview/911928812
Volume 8
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