Chemical diversity in angiosperms − monoterpene synthases control complex reactions that provide the precursors for ecologically and commercially important monoterpenoids

• Published in: The Plant journal : for cell and molecular biology Vol. 119; no. 1; pp. 28 - 55
• Main Authors: Srividya, Narayanan, Kim, Hoshin, Simone, Raugei, Lange, Bernd Markus
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2024; Society for Experimental Biology
• Subjects: Angiospermae; Angiosperms; BASIC BIOLOGICAL SCIENCES; Biosynthesis; carbocation; chemistry; class; crystal structure; enzymatic control; Food industry; Food plants; hydrides; INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Intermediates; Intramolecular Lyases; ligands; Magnoliopsida - enzymology; Magnoliopsida - genetics; Magnoliopsida - metabolism; mechanistic enzymology; Metabolites; molecular dynamics; monoterpene synthase; Monoterpenes - metabolism; Monoterpenoids; Pharmaceutical industry; Plant ecology; Plant Proteins - genetics; Plant Proteins - metabolism; quantum mechanics/molecular mechanics; Quenching; Substrates; carbocation; mechanistic enzymology; crystal structure; quantum mechanics/molecular mechanics; enzymatic control; molecular dynamics; monoterpene synthase

SUMMARY Monoterpene synthases (MTSs) catalyze the first committed step in the biosynthesis of monoterpenoids, a class of specialized metabolites with particularly high chemical diversity in angiosperms. In addition to accomplishing a rate enhancement, these enzymes manage the formation and turnover...