Germline mutations and age at onset of lung adenocarcinoma

• Published in: Cancer Vol. 127; no. 15; pp. 2801 - 2806
• Main Authors: Reckamp, Karen L., Behrendt, Carolyn E., Slavin, Thomas P., Gray, Stacy W., Castillo, Danielle K., Koczywas, Marianna, Cristea, Mihaela C., Babski, Kirsten M., Stearns, Donna, Marcum, Catherine A., Rodriguez, Yenni P., Hass, Amie J., Vecchio, Mary M., Mora, Pamela, Cervantes, Aleck E., Sand, Sharon R., Mejia, Rosa M., Tsou, Terrence C., Salgia, Ravi, Weitzel, Jeffrey N.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2021
• Subjects: Adenocarcinoma; Adenocarcinoma of Lung - genetics; Adult; Age; Age of Onset; Aged; Aged, 80 and over; Anemia; BRCA2; BRCA2 protein; Breast cancer; Cancer screening; Confidence intervals; Deoxyribonucleic acid; Diagnosis; DNA; DNA repair; Early Detection of Cancer; EGFR; Epidermal growth factor receptors; Failure times; Fanconi syndrome; Female; Genes; Genetic Predisposition to Disease; Genetics; Germ-Line Mutation; germline pathogenic variants; hereditary lung cancer; Humans; Lung cancer; Lung Neoplasms - epidemiology; Lung Neoplasms - genetics; Medical screening; Middle Aged; Minority & ethnic groups; Mutation; Oncology; p53 Protein; Repair; Retrospective Studies; Risk groups; Smoking; TP53; hereditary lung cancer; adenocarcinoma; germline pathogenic variants; BRCA2; TP53; EGFR

Background To identify additional at‐risk groups for lung cancer screening, which targets persons with a long history of smoking and thereby misses younger or nonsmoking cases, the authors evaluated germline pathogenic variants (PVs) in patients with lung adenocarcinoma for an association with an ac...