Endoplasmic reticulum stress remodels alveolar bone formation after tooth extraction

• Published in: Journal of cellular and molecular medicine Vol. 24; no. 21; pp. 12411 - 12420
• Main Authors: Chen, Yun, Guo, Yue, Li, Jun, Chen, Ying‐Yi, Liu, Qiong, Tan, Li, Gao, Zheng‐Rong, Zhang, Shao‐Hui, Zhou, Ying‐Hui, Feng, Yun‐Zhi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.11.2020; John Wiley and Sons Inc
• Subjects: Alkaline phosphatase; Alveolar bone; Apoptosis; Bone growth; Bone healing; bone remodelling; Bone turnover; Bones; Cbfa-1 protein; Collagen; Endoplasmic reticulum; endoplasmic reticulum stress; Experiments; Fibrils; Laboratory animals; Original; Osteoblasts; Osteogenesis; Penicillin; Phosphatase; Phosphorylation; Physiology; primary calvarial osteoblasts; Proteins; p‐eIF2α; Saliva; tooth extraction; Tooth extractions; Transmission electron microscopy; Tunicamycin; unfolded protein response; Wound healing; bone remodelling; p-eIF2α; unfolded protein response; tooth extraction; endoplasmic reticulum stress; primary calvarial osteoblasts

Bone healing in tooth extraction sockets occurs in a complex environment containing saliva and many microorganisms and is affected by many factors. Endoplasmic reticulum (ER) stress affects bone metabolism, but the role of ER stress in bone healing after tooth extraction remains unclear. We utilized...