The Role of SLAs in Xenotransplantation

• Published in: Transplantation Vol. 105; no. 2; p. 300
• Main Authors: Ladowski, Joseph M, Hara, Hidetaka, Cooper, David K C
• Format: Journal Article
• Language: English
• Published: United States 01.02.2021
• Subjects: Animals; Animals, Genetically Modified; Antibodies, Heterophile - blood; Antibody Specificity; Antigens, Heterophile - genetics; Antigens, Heterophile - immunology; Graft Rejection - blood; Graft Rejection - immunology; Graft Rejection - prevention & control; Graft Survival; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - immunology; Humans; Species Specificity; Sus scrofa - genetics; Sus scrofa - immunology; Transplantation Tolerance; Transplantation, Heterologous - adverse effects

Advances in genetic engineering, particularly CRISPR/Cas9, have resulted in the development of a triple glycan-knockout (TKO) pig. There is minimal human antipig antibody binding to TKO pig cells. The TKO background has decreased antibody binding to a sufficiently low level that any additional xenoa...