Neuropathological correlates of amyloid PET imaging in Down syndrome

• Published in: Developmental neurobiology (Hoboken, N.J.) Vol. 79; no. 7; pp. 750 - 766
• Main Authors: Abrahamson, Eric E., Head, Elizabeth, Lott, Ira T., Handen, Benjamin L., Mufson, Elliott J., Christian, Bradley T., Klunk, William E., Ikonomovic, Milos D.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2019
• Subjects: Aging; Alzheimer's disease; amyloid; Amyloid beta-Peptides - metabolism; Animals; Autopsy; Axons; Brain - diagnostic imaging; Brain - metabolism; Cortex; Dementia disorders; Down syndrome; Down Syndrome - diagnostic imaging; Down Syndrome - metabolism; Down's syndrome; Humans; Neurodegenerative diseases; Neuroimaging; Neuropathology; Pathology; Positron emission tomography; Positron-Emission Tomography - methods; Senile plaques; striatum; β-Amyloid; amyloid; Down syndrome; striatum; positron emission tomography; Alzheimer's disease; neuropathology

Down syndrome (DS) results in an overproduction of amyloid‐β (Aβ) peptide associated with early onset of Alzheimer's disease (AD). DS cases have Aβ deposits detectable histologically as young as 12–30 years of age, primarily in the form of diffuse plaques, the type of early amyloid pathology al...