The complex role of Wnt ligands in type 2 diabetes mellitus and related complications

• Published in: Journal of cellular and molecular medicine Vol. 25; no. 14; pp. 6479 - 6495
• Main Authors: Nie, Xiaobo, Wei, Xiaoyun, Ma, Han, Fan, Lili, Chen, Wei‐Dong
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2021; John Wiley and Sons Inc
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Antagonists; canonical Wnt signalling pathway; Cell division; Chronic illnesses; complications; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - pathology; Diabetic retinopathy; Disease; Genes; Humans; Insulin resistance; Kinases; Ligands; Low Density Lipoprotein Receptor-Related Protein-6 - genetics; Lymphoma; Metabolism; non‐canonical Wnt signalling pathway; Pathogenesis; Proteins; Review; Reviews; Roles; Serine-Arginine Splicing Factors - genetics; Signal transduction; Transcription factors; Wnt protein; Wnt Proteins - classification; Wnt Proteins - genetics; Wnt Signaling Pathway - genetics; Wnt‐based therapeutics; complications; diabetes; Wnt-based therapeutics; canonical Wnt signalling pathway; non-canonical Wnt signalling pathway

Type 2 diabetes mellitus (T2DM) is one of the major chronic diseases, whose prevalence is increasing dramatically worldwide and can lead to a range of serious complications. Wnt ligands (Wnts) and their activating Wnt signalling pathways are closely involved in the regulation of various processes th...