Acquired coagulation disorders: revisited using global coagulation/anticoagulation testing

• Published in: British journal of haematology Vol. 147; no. 1; pp. 77 - 82
• Main Authors: Tripodi, Armando, Chantarangkul, Veena, Mannucci, Pier M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2009; Blackwell
• Subjects: Biological and medical sciences; bleeding disorders; Blood Coagulation Disorders - diagnosis; Blood Coagulation Disorders - etiology; Blood Coagulation Disorders, Inherited - diagnosis; Blood Coagulation Tests - methods; coagulation factors; Hematologic and hematopoietic diseases; Humans; Infant, Newborn; Liver Cirrhosis - complications; liver disease; Medical sciences; neonatal haematology; Partial Thromboplastin Time; Platelet diseases and coagulopathies; Prothrombin Time; thrombin; Human; Neonatal; Serine endopeptidases; Hematology; liver disease; Enzyme; Acquired; Hepatic disease; Thrombin; Hemopathy; Anticoagulant; Medical screening; Peptidases; bleeding disorders; Newborn; Treatment; neonatal haematology; Hydrolases; Digestive diseases; Coagulation factor; coagulation factors; Coagulopathy

Summary Acquired coagulation defects are characterized by a decrease of both pro‐ and anti‐coagulants. Because of this, we hypothesise that global tests, such as the prothrombin and partial thromboplastin times (PT and APTT), might be unsuitable for their investigation. Indeed, these tests are not g...