Acetyltransferase p300 regulates atrial fibroblast senescence and age‐related atrial fibrosis through p53/Smad3 axis

• Published in: Aging cell Vol. 22; no. 1; pp. e13743 - n/a
• Main Authors: Gao, Xiao‐Yan, Lai, Ying‐Yu, Luo, Xue‐Shan, Peng, De‐Wei, Li, Qiao‐Qiao, Zhou, Hui‐Shan, Xue, Yu‐Mei, Guo, Hui‐Ming, Zhao, Jun‐Fei, Yang, Hui, Kuang, Su‐Juan, Wang, Zhao‐Yu, Zhang, Meng‐Zhen, Deng, Chun‐Yu, Wu, Shu‐Lin, Rao, Fang
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2023; John Wiley and Sons Inc
• Subjects: Acetyltransferase; Acetyltransferases - metabolism; Age; Aged; Aging; Animals; atrial fibrillation; Atrial Fibrillation - metabolism; Atrial Fibrillation - pathology; Cardiac arrhythmia; Cardiomyopathy; Cardiovascular system; Cell cycle; Cellular Senescence - physiology; Collagen; Correlation analysis; Curcumin; Datasets; Diabetes; Fibroblasts; Fibroblasts - metabolism; Fibrosis; Genes; Geriatrics; GTP-binding protein; Heart attacks; Humans; Immunofluorescence; Immunoprecipitation; Mice; Overexpression; p300; p53; p53 Protein; Senescence; Smad3; Smad3 protein; Smad3 Protein - metabolism; Tumor Suppressor Protein p53 - metabolism; p300; senescence; Smad3; atrial fibrillation; fibrosis; p53

Atrial fibrosis induced by aging is one of the main causes of atrial fibrillation (AF), but the potential molecular mechanism is not clear. Acetyltransferase p300 participates in the cellular senescence and fibrosis, which might be involved in the age‐related atrial fibrosis. Four microarray dataset...