Effect of chromium dinicocysteinate supplementation on circulating levels of insulin, TNF-α, oxidative stress, and insulin resistance in type 2 diabetic subjects: Randomized, double-blind, placebo-controlled study

• Published in: Molecular nutrition & food research Vol. 56; no. 8; pp. 1333 - 1341
• Main Authors: Jain, Sushil K., Kahlon, Gunjan, Morehead, Lester, Dhawan, Richa, Lieblong, Benjamin, Stapleton, Tommie, Caldito, Gloria, Hoeldtke, Robert, Levine, Steven N., Bass III, Pat Farrington
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.08.2012; Wiley
• Subjects: Adult; Biological and medical sciences; Chromium; Cysteine - analogs & derivatives; Cysteine - therapeutic use; Diabetes; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Dietary Supplements; Double-Blind Method; Feeding. Feeding behavior; Female; Food industries; Fundamental and applied biological sciences. Psychology; Humans; Insulin - blood; Insulin Resistance; Intercellular Adhesion Molecule-1 - blood; Interleukin-6 - blood; Interleukin-8 - blood; l-cysteine; Male; Middle Aged; Organometallic Compounds - therapeutic use; Oxidative stress; Oxidative Stress - drug effects; Tumor Necrosis Factor-alpha - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Resistance; Oxidative stress; Cysteine; Aminoacid; Chromium; Insulin resistance; Supplementation; Diabetes; Insulin; Feeding; Heavy metal

Scope Chromium and cysteine supplementation have been shown to improve glucose metabolism in animal studies. This study examined the hypothesis that chromium dinicocysteinate (CDNC), a complex of chromium and l‐cysteine, is beneficial in lowering oxidative stress, vascular inflammation, and glycemia...