Exosome release and cargo in Down syndrome

Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the abili...

Full description

Saved in:
Bibliographic Details
Published inDevelopmental neurobiology (Hoboken, N.J.) Vol. 79; no. 7; pp. 639 - 655
Main Authors Hamlett, Eric D., LaRosa, Angela, Mufson, Elliott J., Fortea, Juan, Ledreux, Aurélie, Granholm, Ann‐Charlotte
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.07.2019
Subjects
Aging
Alzheimer's disease
Animals
biomarkers
Cell Communication - physiology
Cell interactions
Cell signaling
Complications
Down syndrome
Down Syndrome - diagnosis
Down Syndrome - metabolism
Down's syndrome
Endocytosis - physiology
Exosomes
Exosomes - metabolism
Exosomes - pathology
extracellular vesicles
Extracellular Vesicles - metabolism
Extracellular Vesicles - pathology
Humans
Life span
Medical treatment
Neurodegeneration
Neurodegenerative diseases
Neurological diseases
Secretion
Vesicles
neurodegeneration
extracellular vesicles
Down syndrome
Alzheimer's disease
biomarkers
Online AccessGet full text

Cover

Abstract Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the ability to capture extracellular vesicles (EVs) in blood from specific cell types allows for the investigation of novel intracellular processes. Exosomes are one type of EVs that have demonstrated great potential in uncovering new biomarkers of neurodegeneration and disease, and also that appear to be intricately involved in the transsynaptic spread of pathogenic factors underlying Alzheimer's disease and other neurological diseases. Exosomes are nanosized vesicles, generated in endosomal multivesicular bodies (MVBs) and secreted by most cells in the body. Since exosomes are important mediators of intercellular communication and genetic exchange, they have emerged as a major research focus and have revealed novel biological sequelae involved in conditions afflicting the DS population. This review summarizes current knowledge on exosome biology in individuals with DS, both early in life and in aging individuals. Collectively these studies have demonstrated that complex multicellular processes underlying DS etiologies may include abnormal formation and secretion of extracellular vesicles such as exosomes.
AbstractList Down syndrome (DS) is a multisystem disorder affecting one in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the ability to capture extracellular vesicles (EVs) in blood from specific cell types allows for the investigation of novel intracellular processes. Exosomes are one type of EVs that have demonstrated great potential in uncovering new biomarkers of neurodegeneration and disease, and also that appear to be intricately involved in the transsynaptic spread of pathogenic factors underlying Alzheimer’s disease (AD) and other neurological diseases. Exosomes are nanosized vesicles, generated in endosomal multivesicular bodies (MVBs) and secreted by most cells in the body. Since exosomes are important mediators of intercellular communication and genetic exchange, they have emerged as a major research focus and have revealed novel biological sequelae involved in conditions afflicting the DS population. This review summarizes current knowledge on exosome biology in individuals with DS, both early in life and in aging individuals. Collectively these studies have demonstrated that complex multicellular processes underlying DS etiologies may include abnormal formation and secretion of extracellular vesicles such as exosomes.
Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the ability to capture extracellular vesicles (EVs) in blood from specific cell types allows for the investigation of novel intracellular processes. Exosomes are one type of EVs that have demonstrated great potential in uncovering new biomarkers of neurodegeneration and disease, and also that appear to be intricately involved in the transsynaptic spread of pathogenic factors underlying Alzheimer's disease and other neurological diseases. Exosomes are nanosized vesicles, generated in endosomal multivesicular bodies (MVBs) and secreted by most cells in the body. Since exosomes are important mediators of intercellular communication and genetic exchange, they have emerged as a major research focus and have revealed novel biological sequelae involved in conditions afflicting the DS population. This review summarizes current knowledge on exosome biology in individuals with DS, both early in life and in aging individuals. Collectively these studies have demonstrated that complex multicellular processes underlying DS etiologies may include abnormal formation and secretion of extracellular vesicles such as exosomes.
Abstract Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the ability to capture extracellular vesicles (EVs) in blood from specific cell types allows for the investigation of novel intracellular processes. Exosomes are one type of EVs that have demonstrated great potential in uncovering new biomarkers of neurodegeneration and disease, and also that appear to be intricately involved in the transsynaptic spread of pathogenic factors underlying Alzheimer's disease and other neurological diseases. Exosomes are nanosized vesicles, generated in endosomal multivesicular bodies (MVBs) and secreted by most cells in the body. Since exosomes are important mediators of intercellular communication and genetic exchange, they have emerged as a major research focus and have revealed novel biological sequelae involved in conditions afflicting the DS population. This review summarizes current knowledge on exosome biology in individuals with DS, both early in life and in aging individuals. Collectively these studies have demonstrated that complex multicellular processes underlying DS etiologies may include abnormal formation and secretion of extracellular vesicles such as exosomes.
Author Hamlett, Eric D.
Mufson, Elliott J.
Fortea, Juan
Ledreux, Aurélie
LaRosa, Angela
Granholm, Ann‐Charlotte
AuthorAffiliation 6 Department of Biological Sciences and the Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208
4 Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, CIBERNED, Universitat Autònoma de Barcelona, Barcelona, Spain
1 Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425
2 Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425
3 Barrow Neurological Institute, Phoenix, AZ, 85013
5 Alzheimer’s Disease and Other Cognitive Disorders Unit, Department of Neurology, Hospital Clínic, Institut d’Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Barcelona, Spain
AuthorAffiliation_xml – name: 6 Department of Biological Sciences and the Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208
– name: 3 Barrow Neurological Institute, Phoenix, AZ, 85013
– name: 5 Alzheimer’s Disease and Other Cognitive Disorders Unit, Department of Neurology, Hospital Clínic, Institut d’Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Barcelona, Spain
– name: 4 Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, CIBERNED, Universitat Autònoma de Barcelona, Barcelona, Spain
– name: 1 Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425
– name: 2 Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425
Author_xml – sequence: 1
  givenname: Eric D.
  orcidid: 0000-0002-2900-7949
  surname: Hamlett
  fullname: Hamlett, Eric D.
  email: hamlette@musc.edu
  organization: Medical University of South Carolina
– sequence: 2
  givenname: Angela
  surname: LaRosa
  fullname: LaRosa, Angela
  organization: Medical University of South Carolina
– sequence: 3
  givenname: Elliott J.
  surname: Mufson
  fullname: Mufson, Elliott J.
  organization: Barrow Neurological Institute
– sequence: 4
  givenname: Juan
  surname: Fortea
  fullname: Fortea, Juan
  organization: University of Barcelona
– sequence: 5
  givenname: Aurélie
  surname: Ledreux
  fullname: Ledreux, Aurélie
  organization: University of Denver
– sequence: 6
  givenname: Ann‐Charlotte
  surname: Granholm
  fullname: Granholm, Ann‐Charlotte
  organization: University of Denver
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31347291$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1LAzEQhoNU7Ide_AGy4EUKq_nYZLcXQdr6AUUvFryFNJvULbtJTbrW_ntTtxb14GkG5uFhZt4uaBlrFACnCF4iCPFVblR9iXGK8AHooAHBcZawl9a-p6gNut4vIKQEM3gE2gSRJMUD1AH98Yf1tlKRU6USXkXC5JEUbm6jwkQjuzaR35jcBeQYHGpRenWyqz0wvR0_D-_jydPdw_BmEsskyXAsscqpJpnMoECpyJGWSgspidYQa80IojPGWK6zMMoySgYUE4jyWSqoRpCRHrhuvMt6VqlcKrNyouRLV1TCbbgVBf89McUrn9t3npKgy2AQXOwEzr7Vyq94VXipylIYZWvPMWY0TRjENKDnf9CFrZ0J5wVqQAmFON1S_YaSznrvlN4vgyDfRsC3EfCvCAJ89nP9Pfr98wCgBlgXpdr8o-Kjx_G0kX4CrHSSgA
CitedBy_id crossref_primary_10_3390_jcm13051338
crossref_primary_10_2147_CIA_S288415
crossref_primary_10_1159_000514437
crossref_primary_10_1002_dneu_22717
crossref_primary_10_1007_s00401_024_02743_9
crossref_primary_10_1096_fba_2021_00081
crossref_primary_10_1186_s12964_022_00853_z
crossref_primary_10_3390_ijms21249428
crossref_primary_10_1002_alz_12112
crossref_primary_10_3389_fnins_2020_00761
crossref_primary_10_1155_2021_5558048
crossref_primary_10_1002_alz_13692
crossref_primary_10_3390_jcm10173931
Cites_doi 10.1038/mp.2014.127
10.1186/s12920-019-0473-z
10.1016/j.jalz.2011.09.229
10.1096/fj.14-262048
10.1016/j.biopsych.2011.08.016
10.1038/nrn3983
10.1016/j.ejmech.2018.08.093
10.1016/j.yexmp.2008.10.006
10.1016/j.dadm.2017.02.006
10.1212/WNL.0000000000001702
10.1371/journal.pone.0188802
10.1016/j.neurobiolaging.2018.10.006
10.1073/pnas.0908953107
10.1074/jbc.RA117.000713
10.1080/20013078.2017.1378056
10.1186/s13024-016-0143-y
10.1002/biot.201600175
10.1016/j.jalz.2015.07.490
10.3233/JAD-160567
10.1016/j.dadm.2016.04.001
10.1038/341226a0
10.3389/fnmol.2018.00434
10.1016/j.neurobiolaging.2017.04.006
10.1111/nan.12084
10.1016/bs.acc.2016.07.003
10.1074/jbc.M609475200
10.1006/nbdi.1996.0003
10.3233/JAD-170773
10.1523/JNEUROSCI.2517-15.2016
10.3389/fimmu.2014.00525
10.1186/s13063-016-1370-9
10.1159/000488943
10.4103/1673-5374.198966
10.1093/nar/gkr828
10.3389/fnins.2017.00229
10.3389/fimmu.2014.00403
10.3389/fphys.2012.00124
10.1006/exnr.1999.7289
10.2174/1567205012666150921095505
10.1016/j.neurobiolaging.2017.05.019
10.1016/j.ejpn.2018.09.004
10.1016/j.bbadis.2015.11.007
10.1074/jbc.M112.404467
10.1074/jbc.M707358200
10.1002/ajmg.1320370755
10.1016/j.freeradbiomed.2017.08.028
10.1001/archneur.1995.00540280065020
10.1046/j.1471-4159.2000.741185.x
10.1002/gps.2321
10.1093/nar/gks832
10.1016/j.tins.2018.03.006
10.1073/pnas.0603838103
10.1096/fj.201700359
10.1016/j.jacc.2016.09.934
10.1016/j.biomaterials.2017.10.012
10.1007/s00249-007-0246-z
10.2174/1567205012666151020114607
10.1111/nan.12406
10.1007/s10266-018-0395-9
10.1002/dneu.22658
10.1096/fj.201700731R
10.1111/jir.12026
10.1093/brain/awy289
10.1242/jcs.215210
10.1186/s40478-017-0466-0
10.1016/j.febslet.2014.11.027
10.1098/rstb.2016.0479
10.1074/mcp.M112.027086
10.2217/pgs-2018-0149
10.1523/JNEUROSCI.5699-09.2010
10.1093/cercor/bhy323
10.1017/S1355617718000206
10.1016/S1474-4422(18)30285-0
10.1016/j.jalz.2014.10.007
10.1016/j.dadm.2017.05.001
10.1016/j.biopsych.2010.05.030
10.1038/s41467-017-02533-w
10.1159/000441419
10.1002/acn3.571
10.1016/j.pharmthera.2018.09.010
10.1016/j.semcdb.2017.08.022
10.1016/j.repbio.2017.09.007
10.1186/s40478-018-0559-4
10.1016/S0304-3940(98)00317-6
10.1159/000442941
10.1016/S0166-4328(02)00082-7
10.1016/j.semcdb.2015.02.007
10.3233/JAD-170390
10.2147/IJN.S170680
10.1096/fj.201600756R
10.1016/j.ceb.2014.05.004
10.1186/s40478-018-0514-4
10.1016/j.ceb.2011.04.008
10.1002/ana.410320510
10.1016/j.neurobiolaging.2004.02.027
10.1016/j.jalz.2016.08.012
10.1074/jbc.M111.253971
10.1093/bioinformatics/btu741
10.3389/fnagi.2018.00004
10.1152/ajpcell.00169.2015
10.1016/S0166-4328(97)81111-4
10.1111/j.1365-2141.1967.tb08741.x
10.3389/fphys.2012.00228
10.1083/jcb.200508014
10.1080/14789450.2018.1537788
10.1136/sextrans-2018-053813
10.3233/JAD-180776
10.1111/jir.12342
10.1016/j.neurobiolaging.2015.06.020
10.1016/j.freeradbiomed.2017.10.001
10.1016/j.mcn.2010.11.004
10.4132/jptm.2017.05.21
10.1016/j.nicl.2017.10.022
10.1126/science.1260419
10.1016/j.bbr.2009.08.034
10.1080/15476286.2015.1100795
10.1111/jcmm.12834
10.1021/acs.molpharmaceut.8b00901
10.1096/fj.201802319R
10.1016/S0021-9258(18)48095-7
10.1111/desc.12468
10.1016/j.jacc.2016.08.073
10.1186/alzrt213
10.1016/j.jalz.2014.06.008
10.1093/biosci/biv084
10.1002/prca.200700522
10.1186/s13287-015-0116-z
10.1093/jnen/62.9.917
10.1038/ng1095-177
10.1249/MSS.0000000000001672
10.1111/j.1600-0854.2007.00677.x
10.3389/fphys.2012.00145
10.1016/j.jprot.2014.04.028
10.1016/S0304-3940(97)00966-X
10.1186/1471-2407-12-421
10.2217/bmm.13.63
10.1083/jcb.201211138
10.1158/0008-5472.CAN-07-6538
10.1016/j.mcn.2005.12.003
ContentType Journal Article
Copyright 2019 Wiley Periodicals, Inc.
Copyright © 2019 Wiley Periodicals, Inc.
Copyright_xml – notice: 2019 Wiley Periodicals, Inc.
– notice: Copyright © 2019 Wiley Periodicals, Inc.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QR
7TK
8FD
FR3
K9.
P64
7X8
5PM
DOI 10.1002/dneu.22712
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Chemoreception Abstracts
Neurosciences Abstracts
Technology Research Database
Engineering Research Database
ProQuest Health & Medical Complete (Alumni)
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest Health & Medical Complete (Alumni)
Chemoreception Abstracts
Engineering Research Database
Technology Research Database
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList

CrossRef
ProQuest Health & Medical Complete (Alumni)
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1932-846X
EndPage 655
ExternalDocumentID 10_1002_dneu_22712
31347291
DNEU22712
Genre reviewArticle
Review
Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: Fundació Bancaria La Caixa
  funderid: PERIS SLT006/17/125
– fundername: Carlos III Institute of Health
  funderid: PI14/01126 ; PI17/01019
– fundername: Alzheimer’s Association
  funderid: AARG-18-565696
– fundername: National Institutes of Health
  funderid: R01 AG056850-01A1
– fundername: Marató TV3
  funderid: 20141210
– fundername: National Institute on Aging
  funderid: R21AG056974; RO1AG14449
– fundername: NIA NIH HHS
  grantid: RF1 AG056850
– fundername: NIA NIH HHS
  grantid: R21 AG056974
– fundername: NIA NIH HHS
  grantid: P01 AG014449
– fundername: NIA NIH HHS
  grantid: RF1 AG061566
– fundername: NIA NIH HHS
  grantid: R01 AG061566
GroupedDBID ---
-DZ
.3N
.GA
.Y3
05W
0R~
10A
1L6
1OC
1ZS
24P
31~
33P
3SF
3WU
4.4
4ZD
50Y
50Z
51W
51X
52M
52N
52O
52P
52S
52T
52U
52W
52X
53G
5GY
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A03
AAESR
AAEVG
AAHHS
AANLZ
AAONW
AASGY
AAXRX
AAZKR
ABCQN
ABCUV
ABEML
ABIVO
ABJNI
ABLJU
ABPVW
ACAHQ
ACCFJ
ACCZN
ACGFS
ACIWK
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBBV
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADXAS
ADZMN
ADZOD
AEEZP
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFFPM
AFGKR
AFPWT
AFRAH
AFZJQ
AHBTC
AHMBA
AITYG
AIURR
AIWBW
AJBDE
AJXKR
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
AMYDB
ATUGU
AUFTA
AZBYB
AZVAB
BAFTC
BFHJK
BHBCM
BMNLL
BMXJE
BNHUX
BROTX
BRXPI
BY8
C45
CS3
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRSTM
DU5
EBD
EBS
EJD
EMOBN
F00
F01
F04
F5P
G-S
G.N
GODZA
H.T
H.X
HF~
HGLYW
HHY
HHZ
HZ~
IX1
J0M
JPC
LATKE
LAW
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MEWTI
MK4
MRFUL
MRSTM
MSFUL
MSSTM
MXFUL
MXSTM
N04
N05
N9A
NF~
NNB
O66
O9-
OIG
OK1
OVD
P2P
P2W
P2X
P4D
PQQKQ
Q.N
Q11
QB0
QRW
R.K
ROL
RWI
RX1
SUPJJ
SV3
TEORI
UB1
V2E
W8V
W99
WBKPD
WIH
WIK
WIN
WJL
WNSPC
WOHZO
WQJ
WRC
WXSBR
WYISQ
XG1
XJT
XV2
~IA
~WT
1OB
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QR
7TK
8FD
FR3
K9.
P64
7X8
5PM
ID FETCH-LOGICAL-c4482-c2ed5f38c80a17ad1fcefacc3ff02ff6315b666df8d1f8853952301db7a5f1063
IEDL.DBID DR2
ISSN 1932-8451
IngestDate Tue Sep 17 21:22:41 EDT 2024
Fri Aug 16 10:08:04 EDT 2024
Thu Oct 10 18:09:43 EDT 2024
Thu Sep 26 15:59:15 EDT 2024
Sat Sep 28 08:17:46 EDT 2024
Sat Aug 24 01:10:27 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Keywords neurodegeneration
extracellular vesicles
Down syndrome
Alzheimer's disease
biomarkers
Language English
License 2019 Wiley Periodicals, Inc.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4482-c2ed5f38c80a17ad1fcefacc3ff02ff6315b666df8d1f8853952301db7a5f1063
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ORCID 0000-0002-2900-7949
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388580
PMID 31347291
PQID 2295350275
PQPubID 946356
PageCount 17
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7388580
proquest_miscellaneous_2265746025
proquest_journals_2295350275
crossref_primary_10_1002_dneu_22712
pubmed_primary_31347291
wiley_primary_10_1002_dneu_22712_DNEU22712
PublicationCentury 2000
PublicationDate July 2019
2019-07-00
20190701
PublicationDateYYYYMMDD 2019-07-01
PublicationDate_xml – month: 07
  year: 2019
  text: July 2019
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Hoboken
PublicationTitle Developmental neurobiology (Hoboken, N.J.)
PublicationTitleAlternate Dev Neurobiol
PublicationYear 2019
Publisher Wiley Subscription Services, Inc
Publisher_xml – name: Wiley Subscription Services, Inc
References 2006; 31
2019; 95
2009; 86
2010; 107
2004; 25
2019; 12
2008; 37
2016; 30
2018; 41
2006; 172
2014; 29
2013; 7
2018; 44
2012; 12
2013; 5
2016; 36
2018; 6
2018; 9
2018; 8
2018; 5
2010; 25
2018; 293
2015; 85
1989; 341
2017; 78
2016; 310
2016; 41
1967; 13
2007; 1
2018; 32
2010; 30
2014; 12
1995; 52
2017; 61
2017; 60
2010; 206
2007; 282
2019; 33
2019; 107
2018; 23
2016; 17
1992; 32
2014; 40
2016; 16
2018; 20
2016; 13
2016; 12
2018; 25
2018; 24
2018; 17
2018; 194
2016; 3
2017; 58
2000; 74
2018; 114
2017; 56
2015; 65
2016; 20
1996; 82
2018; 11
2018; 10
2018; 16
1990; 7
2018; 15
2006; 103
2012; 40
2018; 13
2017; 5
1987; 262
2017; 6
2017; 8
2015; 36
2012; 287
2015; 347
2015; 589
2015; 31
2008; 9
2013; 200
2017; 9
2018; 373
2018; 131
2012; 71
2017; 31
2014; 5
2010; 68
2015; 40
2013; 12
2000; 161
2014; 58
2008; 68
1998; 247
2018; 74
2011; 23
2014; 7
1996; 3
2011; 286
1998; 241
1996; 7
2018; 142
2015; 12
2017; 20
2015; 6
2015; 16
2003; 139
1973; 78
2019; 79
2015; 11
1995; 11
2018; 62
2016; 1862
2018; 67
2014; 106
2012; 3
2015; 29
2018; 150
2017; 17
2015; 20
2017; 11
2017; 12
2018; 158
2018
2018; 52
2011; 46
2018; 50
2003; 62
2016; 68
2012; 8
e_1_2_13_120_1
e_1_2_13_143_1
e_1_2_13_24_1
e_1_2_13_47_1
e_1_2_13_20_1
e_1_2_13_66_1
e_1_2_13_101_1
e_1_2_13_124_1
e_1_2_13_85_1
e_1_2_13_8_1
e_1_2_13_62_1
e_1_2_13_81_1
e_1_2_13_92_1
e_1_2_13_96_1
e_1_2_13_117_1
e_1_2_13_17_1
Lao P. J. (e_1_2_13_80_1) 2017; 9
e_1_2_13_13_1
e_1_2_13_36_1
e_1_2_13_59_1
e_1_2_13_131_1
e_1_2_13_32_1
e_1_2_13_55_1
e_1_2_13_78_1
e_1_2_13_112_1
e_1_2_13_51_1
e_1_2_13_74_1
e_1_2_13_70_1
e_1_2_13_4_1
e_1_2_13_105_1
e_1_2_13_88_1
e_1_2_13_128_1
e_1_2_13_29_1
e_1_2_13_109_1
e_1_2_13_25_1
e_1_2_13_48_1
e_1_2_13_100_1
e_1_2_13_142_1
e_1_2_13_21_1
e_1_2_13_44_1
e_1_2_13_67_1
e_1_2_13_104_1
e_1_2_13_123_1
Gao D. (e_1_2_13_40_1) 2018; 8
e_1_2_13_86_1
Xiao H. (e_1_2_13_139_1) 2014; 12
e_1_2_13_9_1
e_1_2_13_63_1
e_1_2_13_82_1
e_1_2_13_91_1
Salido‐Guadarrama I. (e_1_2_13_116_1) 2014; 7
e_1_2_13_95_1
e_1_2_13_99_1
e_1_2_13_18_1
e_1_2_13_14_1
e_1_2_13_111_1
e_1_2_13_130_1
e_1_2_13_37_1
e_1_2_13_79_1
e_1_2_13_10_1
e_1_2_13_56_1
e_1_2_13_115_1
e_1_2_13_134_1
e_1_2_13_33_1
e_1_2_13_75_1
e_1_2_13_52_1
e_1_2_13_71_1
e_1_2_13_5_1
e_1_2_13_108_1
e_1_2_13_127_1
Winston C. N. (e_1_2_13_135_1) 2016; 3
e_1_2_13_49_1
e_1_2_13_122_1
e_1_2_13_141_1
e_1_2_13_26_1
e_1_2_13_68_1
e_1_2_13_45_1
e_1_2_13_126_1
e_1_2_13_87_1
e_1_2_13_145_1
e_1_2_13_22_1
e_1_2_13_64_1
e_1_2_13_103_1
e_1_2_13_41_1
e_1_2_13_60_1
e_1_2_13_83_1
e_1_2_13_6_1
e_1_2_13_90_1
e_1_2_13_94_1
Gibson D. (e_1_2_13_43_1) 1973; 78
e_1_2_13_98_1
e_1_2_13_119_1
e_1_2_13_138_1
e_1_2_13_19_1
e_1_2_13_133_1
e_1_2_13_15_1
e_1_2_13_38_1
e_1_2_13_57_1
e_1_2_13_110_1
e_1_2_13_137_1
e_1_2_13_11_1
e_1_2_13_34_1
e_1_2_13_53_1
e_1_2_13_76_1
e_1_2_13_114_1
e_1_2_13_30_1
e_1_2_13_72_1
e_1_2_13_2_1
e_1_2_13_107_1
e_1_2_13_121_1
e_1_2_13_144_1
e_1_2_13_46_1
e_1_2_13_69_1
e_1_2_13_102_1
e_1_2_13_125_1
e_1_2_13_23_1
e_1_2_13_42_1
e_1_2_13_65_1
Dekker A. D. (e_1_2_13_27_1) 2017; 8
e_1_2_13_84_1
e_1_2_13_7_1
e_1_2_13_61_1
e_1_2_13_140_1
e_1_2_13_93_1
e_1_2_13_97_1
e_1_2_13_118_1
e_1_2_13_39_1
e_1_2_13_35_1
e_1_2_13_16_1
e_1_2_13_58_1
e_1_2_13_113_1
e_1_2_13_136_1
e_1_2_13_31_1
e_1_2_13_77_1
e_1_2_13_12_1
e_1_2_13_54_1
e_1_2_13_73_1
e_1_2_13_50_1
e_1_2_13_3_1
Wegiel J. (e_1_2_13_132_1) 1996; 7
e_1_2_13_106_1
e_1_2_13_129_1
e_1_2_13_89_1
e_1_2_13_28_1
References_xml – volume: 30
  start-page: 3853
  year: 2016
  end-page: 3859
  article-title: Cargo proteins of plasma astrocyte‐derived exosomes in Alzheimer's disease
  publication-title: The FASEB Journal
– volume: 194
  start-page: 199
  year: 2018
  end-page: 221
  article-title: DYRK1A and cognition: A lifelong relationship
  publication-title: Pharmacology & Therapeutics
– volume: 65
  start-page: 783
  year: 2015
  end-page: 797
  article-title: Extracellular vesicles: Composition, biological relevance, and methods of study
  publication-title: BioScience
– volume: 60
  start-page: 757
  year: 2017
  end-page: 768
  article-title: Sphingolipid‐enriched extracellular vesicles and Alzheimer's disease: A decade of research
  publication-title: Journal of Alzheimer's Disease
– volume: 36
  start-page: 2907.e1
  year: 2015
  end-page: 2907.e10
  article-title: Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome
  publication-title: Neurobiology of Aging
– volume: 310
  start-page: C800
  year: 2016
  end-page: 807
  article-title: Human vascular endothelial cells transport foreign exosomes from cow's milk by endocytosis
  publication-title: American Journal of Physiology Cell Physiology
– volume: 25
  start-page: 18
  issue: 1
  year: 2018
  end-page: 22
  article-title: The aging process alters IL‐1β and CD63 levels differently in extracellular vesicles obtained from the plasma and cerebrospinal fluid
  publication-title: Neuroimmunomodulation
– volume: 103
  start-page: 11172
  year: 2006
  end-page: 11177
  article-title: Alzheimer's disease beta‐amyloid peptides are released in association with exosomes
  publication-title: Proceedings of the National Academy of Sciences
– volume: 17
  start-page: 263
  year: 2018
  end-page: 271
  article-title: Neuroimaging and other modalities to assess Alzheimer's disease in Down syndrome
  publication-title: NeuroImage Clinical
– volume: 5
  start-page: 525
  year: 2014
  article-title: Update on controls for isolation and quantification methodology of extracellular vesicles derived from adipose tissue mesenchymal stem cells
  publication-title: Frontiers in Immunology
– volume: 13
  start-page: 18
  year: 2016
  end-page: 29
  article-title: Aging in Down syndrome and the development of Alzheimer's disease neuropathology
  publication-title: Current Alzheimer Research
– volume: 79
  start-page: 711
  issue: 7
  year: 2019
  end-page: 715
  article-title: Tau PET imaging for staging of Alzheimer's disease in Down syndrome
  publication-title: Developmental Neurobiology
– volume: 150
  start-page: 137
  year: 2018
  end-page: 149
  article-title: Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy
  publication-title: Biomaterials
– volume: 200
  start-page: 373
  year: 2013
  end-page: 383
  article-title: Extracellular vesicles: Exosomes, microvesicles, and friends
  publication-title: Journal of Cell Biology
– volume: 6
  start-page: 56
  year: 2018
  article-title: The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome
  publication-title: Acta Neuropathologica Communications
– volume: 131
  year: 2018
  article-title: The interplay between exosomes and autophagy – Partners in crime
  publication-title: Journal of Cell Science
– volume: 36
  start-page: 3648
  year: 2016
  end-page: 3659
  article-title: Overexpression of Dyrk1A, a Down syndrome candidate, decreases excitability and impairs gamma oscillations in the prefrontal cortex
  publication-title: Journal of Neuroscience
– volume: 33
  start-page: 5082
  issue: 4
  year: 2019
  end-page: 5088
  article-title: Altered levels of plasma neuron‐derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury
  publication-title: The FASEB Journal
– volume: 12
  start-page: 421
  year: 2012
  article-title: Hypoxic enhancement of exosome release by breast cancer cells
  publication-title: BMC Cancer
– volume: 31
  start-page: 2729
  year: 2017
  end-page: 2743
  article-title: Amyloid precursor protein and endosomal‐lysosomal dysfunction in Alzheimer's disease: Inseparable partners in a multifactorial disease
  publication-title: The FASEB Journal
– volume: 5
  start-page: 65
  year: 2017
  article-title: Enhanced exosome secretion in Down syndrome brain – A protective mechanism to alleviate neuronal endosomal abnormalities
  publication-title: Acta Neuropathologica Communications
– volume: 16
  start-page: 564
  year: 2015
  end-page: 574
  article-title: A genetic cause of Alzheimer disease: Mechanistic insights from Down syndrome
  publication-title: Nature Reviews Neuroscience
– volume: 61
  start-page: 594
  year: 2017
  end-page: 603
  article-title: Age and gender‐related differences in emotional and behavioural problems and autistic features in children and adolescents with Down syndrome: A survey‐based study of 674 individuals
  publication-title: Journal of Intellectual Disability Research
– volume: 293
  start-page: 8956
  year: 2018
  end-page: 8968
  article-title: Autophagy regulates exosomal release of prions in neuronal cells
  publication-title: Journal of Biological Chemistry
– volume: 12
  start-page: 2148
  year: 2013
  end-page: 2159
  article-title: Oncogenic H‐ras reprograms Madin‐Darby canine kidney (MDCK) cell‐derived exosomal proteins following epithelial‐mesenchymal transition
  publication-title: Molecular & Cellular Proteomics
– volume: 67
  start-page: 541
  issue: 2
  year: 2018
  end-page: 553
  article-title: Neuronal exosome‐derived human Tau is toxic to recipient mouse neurons in vivo
  publication-title: Journal of Alzheimer's Disease
– volume: 12
  start-page: 5
  year: 2017
  article-title: The release and trans‐synaptic transmission of Tau via exosomes
  publication-title: Molecular Neurodegeneration
– volume: 37
  start-page: 323
  year: 2008
  end-page: 332
  article-title: The role of exosomes in the processing of proteins associated with neurodegenerative diseases
  publication-title: European Biophysics Journal
– volume: 52
  start-page: 1
  year: 2018
  end-page: 8
  article-title: Extracellular vesicles and the promise of continuous liquid biopsies
  publication-title: Journal of Pathology and Translational Medicine
– volume: 3
  start-page: 16
  year: 1996
  end-page: 32
  article-title: Sequence of deposition of heterogeneous amyloid beta‐peptides and APO E in Down syndrome: Implications for initial events in amyloid plaque formation
  publication-title: Neurobiology of Diseases
– volume: 172
  start-page: 923
  year: 2006
  end-page: 935
  article-title: Exosomes and HIV Gag bud from endosome‐like domains of the T cell plasma membrane
  publication-title: Journal of Cell Biology
– volume: 20
  issue: 6
  year: 2017
  article-title: Visual attention and academic performance in children with developmental disabilities and behavioural attention deficits
  publication-title: Developmental Science
– volume: 95
  start-page: 246
  issue: 4
  year: 2019
  end-page: 250
  article-title: Exosomal microRNA profiles from serum and cerebrospinal fluid in neurosyphilis
  publication-title: Sexually Transmitted Infections
– volume: 8
  start-page: 1
  year: 2017
  end-page: 10
  article-title: Cerebrospinal fluid biomarkers for Alzheimer's disease in Down syndrome
  publication-title: Alzheimer's & Dementia
– volume: 13
  start-page: 5335
  year: 2018
  end-page: 5345
  article-title: Effect of young exosomes injected in aged mice
  publication-title: International Journal of Nanomedicine
– volume: 3
  start-page: 124
  year: 2012
  article-title: Exosomes: Vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?
  publication-title: Frontiers in Physiology
– volume: 74
  start-page: 1185
  year: 2000
  end-page: 1196
  article-title: Reduction in TrkA‐immunoreactive neurons is not associated with an overexpression of galaninergic fibers within the nucleus basalis in Down's syndrome
  publication-title: Journal of Neurochemistry
– volume: 11
  start-page: 177
  year: 1995
  end-page: 184
  article-title: A mouse model for Down syndrome exhibits learning and behaviour deficits
  publication-title: Nature Genetics
– volume: 282
  start-page: 18197
  year: 2007
  end-page: 18205
  article-title: Alkalizing drugs induce accumulation of amyloid precursor protein by‐products in luminal vesicles of multivesicular bodies
  publication-title: Journal of Biological Chemistry
– volume: 12
  start-page: 538
  year: 2016
  end-page: 545
  article-title: The pattern of amyloid accumulation in the brains of adults with Down syndrome
  publication-title: Alzheimer's & Dementia
– volume: 68
  start-page: 885
  year: 2010
  end-page: 893
  article-title: Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression
  publication-title: Biological Psychiatry
– volume: 158
  start-page: 559
  year: 2018
  end-page: 592
  article-title: DYRK1A kinase inhibition with emphasis on neurodegeneration: A comprehensive evolution story‐cum‐perspective
  publication-title: European Journal of Medicinal Chemistry
– volume: 56
  start-page: 41
  year: 2017
  end-page: 49
  article-title: Brain‐predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline
  publication-title: Neurobiology of Aging
– volume: 9
  start-page: 291
  year: 2018
  article-title: Neuronal lysosomal dysfunction releases exosomes harboring APP C‐terminal fragments and unique lipid signatures
  publication-title: Nature Communications
– volume: 12
  start-page: 19
  year: 2017
  end-page: 22
  article-title: Emerging potential of exosomes for treatment of traumatic brain injury
  publication-title: Neural Regeneration Research
– volume: 3
  start-page: 145
  year: 2012
  article-title: Emerging role of neuronal exosomes in the central nervous system
  publication-title: Frontiers in Physiology
– volume: 12
  year: 2017
  article-title: Increased levels of plasma total tau in adult Down syndrome
  publication-title: PLoS One
– volume: 31
  start-page: 642
  year: 2006
  end-page: 648
  article-title: Exosomes are released by cultured cortical neurones
  publication-title: Molecular and Cellular Neurosciences
– volume: 17
  start-page: 341
  year: 2017
  end-page: 348
  article-title: A method for the isolation and enrichment of purified bovine milk exosomes
  publication-title: Reproductive Biology
– volume: 30
  start-page: 6838
  year: 2010
  end-page: 6851
  article-title: Cell‐produced alpha‐synuclein is secreted in a calcium‐dependent manner by exosomes and impacts neuronal survival
  publication-title: Journal of Neuroscience
– volume: 206
  start-page: 52
  year: 2010
  end-page: 62
  article-title: Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1)
  publication-title: Behavioral Brain Research
– volume: 68
  start-page: 2408
  year: 2016
  end-page: 2411
  article-title: The head and the heart: The Alzheimer's connection
  publication-title: Journal of the American College of Cardiology
– volume: 32
  start-page: 667
  year: 1992
  end-page: 676
  article-title: Disease‐specific patterns of locus coeruleus cell loss
  publication-title: Annals of Neurology
– volume: 12
  start-page: 1355
  year: 2015
  end-page: 1363
  article-title: Exosome‐mediated microRNA transfer plays a role in radiation‐induced bystander effect
  publication-title: RNA Biology
– volume: 24
  start-page: 966
  year: 2018
  end-page: 976
  article-title: Pediatric brain development in Down syndrome: A field in its infancy
  publication-title: Journal of the International Neuropsychological Society
– volume: 12
  start-page: 64
  year: 2014
  article-title: Mast cell exosomes promote lung adenocarcinoma cell proliferation – Role of KIT‐stem cell factor signaling
  publication-title: Cell Communication and Signaling
– volume: 241
  start-page: 13
  year: 1998
  end-page: 16
  article-title: Increased plasma amyloid beta protein 1–42 levels in Down syndrome
  publication-title: Neuroscience Letters
– volume: 74
  start-page: 66
  year: 2018
  end-page: 77
  article-title: Biogenesis and function of ESCRT‐dependent extracellular vesicles
  publication-title: Seminars in Cell & Developmental Biology
– volume: 11
  start-page: 229
  year: 2017
  article-title: Exosomes as carriers of Alzheimer's amyloid‐ss
  publication-title: Frontiers in Neuroscience
– volume: 8
  start-page: 496
  year: 2012
  end-page: 501
  article-title: Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B
  publication-title: Alzheimer's & Dementia
– volume: 58
  start-page: 393
  year: 2014
  end-page: 398
  article-title: The triple challenges associated with age‐related comorbidities in Down syndrome
  publication-title: Journal of Intellectual Disability Research
– volume: 11
  start-page: 434
  year: 2018
  article-title: Therapeutic potential of extracellular vesicles for demyelinating diseases; challenges and opportunities
  publication-title: Frontiers in Molecular Neuroscience
– volume: 1862
  start-page: 909
  year: 2016
  end-page: 914
  article-title: Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome
  publication-title: Biochimica et Biophysica Acta
– volume: 7
  start-page: 274
  year: 1990
  end-page: 281
  article-title: Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis
  publication-title: American Journal of Medical Genetics. Supplement
– volume: 20
  start-page: 49
  issue: 1
  year: 2018
  end-page: 68
  article-title: The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer
  publication-title: Pharmacogenomics
– volume: 60
  start-page: 439
  year: 2017
  end-page: 450
  article-title: PET imaging of Tau pathology and relationship to amyloid, longitudinal MRI, and cognitive change in Down syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)
  publication-title: Journal of Alzheimer's Disease
– volume: 25
  start-page: 1263
  year: 2004
  end-page: 1272
  article-title: Abeta localization in abnormal endosomes: Association with earliest Abeta elevations in AD and Down syndrome
  publication-title: Neurobiology of Aging
– volume: 3
  start-page: 228
  year: 2012
  article-title: Role of exosomes/microvesicles in the nervous system and use in emerging therapies
  publication-title: Frontiers in Physiology
– volume: 20
  start-page: 1457
  year: 2016
  end-page: 1466
  article-title: Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells
  publication-title: Journal of Cellular and Molecular Medicine
– volume: 40
  start-page: 10937
  year: 2012
  end-page: 10949
  article-title: Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion‐infected neuronal cells
  publication-title: Nucleic Acids Research
– volume: 7
  start-page: 769
  year: 2013
  end-page: 778
  article-title: Exosomes: The future of biomarkers in medicine
  publication-title: Biomarkers in Medicine
– volume: 139
  start-page: 47
  year: 2003
  end-page: 57
  article-title: Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome
  publication-title: Behavioral Brain Research
– volume: 71
  start-page: 403
  year: 2012
  end-page: 409
  article-title: Neurobiological elements of cognitive dysfunction in Down syndrome: Exploring the role of APP
  publication-title: Biological Psychiatry
– volume: 106
  start-page: 191
  year: 2014
  end-page: 204
  article-title: Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset
  publication-title: Journal of Proteomics
– volume: 41
  start-page: 123
  year: 2016
  end-page: 136
  article-title: Frontal lobe degeneration in adults with Down syndrome and Alzheimer's disease: A review
  publication-title: Dementia and Geriatric Cognitive Disorders
– volume: 25
  start-page: 202
  year: 2010
  end-page: 207
  article-title: Plasma beta‐amyloid and duration of Alzheimer's disease in adults with Down syndrome
  publication-title: International Journal of Geriatric Psychiatry
– volume: 5
  start-page: 403
  year: 2014
  article-title: Exosomes and autophagy: Coordinated mechanisms for the maintenance of cellular fitness
  publication-title: Frontiers in Immunology
– volume: 68
  start-page: 7864
  year: 2008
  end-page: 7871
  article-title: Senescence‐associated exosome release from human prostate cancer cells
  publication-title: Cancer Research
– volume: 29
  start-page: 116
  year: 2014
  end-page: 125
  article-title: Biogenesis and secretion of exosomes
  publication-title: Current Opinion in Cell Biology
– volume: 341
  start-page: 226
  year: 1989
  end-page: 230
  article-title: Amyloid beta‐protein deposition in tissues other than brain in Alzheimer's disease
  publication-title: Nature
– volume: 282
  start-page: 34850
  year: 2007
  end-page: 34857
  article-title: DYRK1A‐mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease
  publication-title: Journal of Biological Chemistry
– volume: 5
  start-page: 741
  year: 2018
  end-page: 751
  article-title: Aging related cognitive changes associated with Alzheimer's disease in Down syndrome
  publication-title: Annals of Clinical and Translational Neurology
– volume: 6
  start-page: 1378056
  year: 2017
  article-title: Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane
  publication-title: Journal of Extracellular Vesicles
– volume: 13
  start-page: 269
  year: 1967
  end-page: 288
  article-title: The nature and significance of platelet products in human plasma
  publication-title: British Journal of Haematology
– volume: 62
  start-page: 1125
  year: 2018
  end-page: 1140
  article-title: The Past and the future of Alzheimer's disease fluid biomarkers
  publication-title: Journal of Alzheimer's Disease
– volume: 40
  start-page: 89
  year: 2015
  end-page: 96
  article-title: Extracellular vesicles–Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases
  publication-title: Seminars in Cell & Developmental Biology
– volume: 46
  start-page: 409
  year: 2011
  end-page: 418
  article-title: Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity
  publication-title: Molecular and Cellular Neurosciences
– volume: 7
  start-page: 1327
  year: 2014
  end-page: 1338
  article-title: MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer
  publication-title: OncoTargets and Therapy
– volume: 13
  start-page: 541
  issue: 5
  year: 2016
  end-page: 549
  article-title: Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome
  publication-title: Alzheimer's & Dementia
– volume: 78
  start-page: 128
  year: 1973
  end-page: 133
  article-title: Karyotype variation and behavior in Down's syndrome: Methodological review
  publication-title: American Journal of Mental Deficiency
– volume: 41
  start-page: 360
  year: 2018
  end-page: 372
  article-title: Extracellular vesicles: Multimodal envoys in neural maintenance and repair
  publication-title: Trends in Neurosciences
– volume: 74
  start-page: 15
  year: 2018
  end-page: 20
  article-title: Extracellular vesicles, new actors in the search for biomarkers of dementias
  publication-title: Neurobiology of Aging
– volume: 23
  start-page: 158
  issue: 1
  year: 2018
  end-page: 164
  article-title: Increased cerebral microbleeds and cortical superficial siderosis in pediatric patients with Down syndrome
  publication-title: European Journal of Paediatric Neurology
– volume: 85
  start-page: 40
  year: 2015
  end-page: 47
  article-title: Altered lysosomal proteins in neural‐derived plasma exosomes in preclinical Alzheimer disease
  publication-title: Neurology
– volume: 15
  start-page: 887
  year: 2018
  end-page: 910
  article-title: Understanding extracellular vesicle diversity – Current status
  publication-title: Expert Review of Proteomics
– volume: 11
  start-page: 700
  year: 2015
  end-page: 709
  article-title: Down syndrome and Alzheimer's disease: Common pathways, common goals
  publication-title: Alzheimer's & Dementia
– volume: 7
  start-page: 135
  year: 1996
  end-page: 141
  article-title: Differential susceptibility to neurofibrillary pathology among patients with Down syndrome
  publication-title: Dementia
– volume: 50
  start-page: 2024
  year: 2018
  end-page: 2032
  article-title: Moderate exercise enhances endothelial progenitor cell exosomes release and function
  publication-title: Medicine and Science in Sports and Exercise
– volume: 286
  start-page: 40401
  year: 2011
  end-page: 40412
  article-title: Regulation of RCAN1 protein activity by Dyrk1A protein‐mediated phosphorylation
  publication-title: Journal of Biological Chemistry
– volume: 9
  start-page: 1
  year: 2017
  end-page: 9
  article-title: Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population
  publication-title: Alzheimer's & Dementia
– volume: 11
  start-page: 600
  year: 2015
  end-page: 607.e1
  article-title: Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study
  publication-title: Alzheimer's & Dementia
– volume: 373
  start-page: 20160479
  issue: 1737
  year: 2018
  article-title: Why the need and how to approach the functional diversity of extracellular vesicles
  publication-title: Philosophical Transactions of the Royal Society B: Biological Sciences
– volume: 52
  start-page: 379
  year: 1995
  end-page: 391
  article-title: Age‐related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease
  publication-title: Archives of Neurology
– volume: 68
  start-page: 2395
  year: 2016
  end-page: 2407
  article-title: Abeta amyloid pathology affects the hearts of patients with Alzheimer's disease: Mind the heart
  publication-title: Journal of the American College of Cardiology
– volume: 6
  start-page: 127
  year: 2015
  article-title: Human bone marrow‐ and adipose‐mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species
  publication-title: Stem Cell Research & Therapy
– volume: 247
  start-page: 171
  year: 1998
  end-page: 174
  article-title: Impaired short‐ and long‐term memory in Ts65Dn mice, a model for Down syndrome
  publication-title: Neuroscience Letters
– volume: 114
  start-page: 110
  year: 2018
  end-page: 121
  article-title: Exosomal biomarkers in Down syndrome and Alzheimer's disease
  publication-title: Free Radical Biology and Medicine
– volume: 29
  start-page: 589
  year: 2015
  end-page: 596
  article-title: Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease
  publication-title: The FASEB Journal
– volume: 16
  start-page: 24
  issue: 1
  year: 2018
  end-page: 40
  article-title: Exosome as a novel shuttle for delivery of therapeutics across biological barriers
  publication-title: Molecular Pharmaceutics
– year: 2018
  article-title: Aging‐related changes in cognition and cortical integrity are associated with serum expression of candidate MicroRNAs for Alzheimer disease
  publication-title: Cerebral Cortex
– volume: 9
  start-page: 230
  year: 2008
  end-page: 250
  article-title: Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells
  publication-title: Traffic
– volume: 44
  start-page: 314
  year: 2018
  end-page: 327
  article-title: The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome
  publication-title: Neuropathology and Applied Neurobiology
– volume: 12
  start-page: 1600175
  issue: 1
  year: 2017
  article-title: Autophagy and the endo/exosomal pathways in health and disease
  publication-title: Biotechnology Journal
– volume: 142
  start-page: 163
  issue: 1
  year: 2018
  end-page: 175
  article-title: Apolipoprotein E4 genotype compromises brain exosome production
  publication-title: Brain
– volume: 107
  start-page: 1630
  year: 2010
  end-page: 1635
  article-title: Alzheimer's‐related endosome dysfunction in Down syndrome is Abeta‐independent but requires APP and is reversed by BACE‐1 inhibition
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
– volume: 17
  start-page: 370
  year: 2016
  article-title: Towards onset prevention of cognition decline in adults with Down syndrome (The TOP‐COG study): A pilot randomised controlled trial
  publication-title: Trials
– volume: 8
  start-page: 2165
  year: 2018
  end-page: 2175
  article-title: Exosomes in cancer therapy: A novel experimental strategy
  publication-title: American Journal of Cancer Research
– volume: 40
  start-page: D1241
  year: 2012
  end-page: 1244
  article-title: ExoCarta 2012: Database of exosomal proteins, RNA and lipids
  publication-title: Nucleic Acids Research
– volume: 16
  start-page: 62
  year: 2016
  end-page: 68
  article-title: Increased mammalian target of rapamycin signaling contributes to the accumulation of protein oxidative damage in a mouse model of Down's syndrome
  publication-title: Neuro‐Degenerative Diseases
– volume: 40
  start-page: 121
  year: 2014
  end-page: 135
  article-title: Phosphorylation of tau protein at sites Ser(396–404) is one of the earliest events in Alzheimer's disease and Down syndrome
  publication-title: Neuropathology and Applied Neurobiology
– volume: 107
  start-page: 271
  issue: 3
  year: 2019
  end-page: 284
  article-title: Exosomes in perspective: a potential surrogate for stem cell therapy
  publication-title: Odontology
– volume: 287
  start-page: 43108
  year: 2012
  end-page: 43115
  article-title: The exosome secretory pathway transports amyloid precursor protein carboxyl‐terminal fragments from the cell into the brain extracellular space
  publication-title: Journal of Biological Chemistry
– volume: 589
  start-page: 84
  year: 2015
  end-page: 88
  article-title: A potential function for neuronal exosomes: Sequestering intracerebral amyloid‐beta peptide
  publication-title: FEBS Letters
– volume: 31
  start-page: 933
  year: 2015
  end-page: 939
  article-title: EVpedia: A community web portal for extracellular vesicles research
  publication-title: Bioinformatics
– volume: 3
  start-page: 63
  year: 2016
  end-page: 72
  article-title: Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile
  publication-title: Alzheimer's & Dementia
– volume: 32
  start-page: 888
  year: 2018
  end-page: 893
  article-title: Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease
  publication-title: The FASEB Journal
– volume: 62
  start-page: 917
  year: 2003
  end-page: 926
  article-title: Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome
  publication-title: Journal of Neuropathology and Experimental Neurology
– volume: 114
  start-page: 40
  year: 2018
  end-page: 51
  article-title: Dysfunction of autophagy and endosomal‐lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's disease
  publication-title: Free Radical Biology and Medicine
– volume: 5
  start-page: 48
  year: 2013
  article-title: Dominantly Inherited Alzheimer Network: Facilitating research and clinical trials
  publication-title: Alzheimer's Research & Therapy
– volume: 20
  start-page: 1188
  year: 2015
  end-page: 1196
  article-title: Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment
  publication-title: Molecular Psychiatry
– volume: 23
  start-page: 452
  year: 2011
  end-page: 457
  article-title: MVB vesicle formation: ESCRT‐dependent, ESCRT‐independent and everything in between
  publication-title: Current Opinion in Cell Biology
– volume: 1
  start-page: 1446
  year: 2007
  end-page: 1461
  article-title: Oligodendrocytes secrete exosomes containing major myelin and stress‐protective proteins: Trophic support for axons?
  publication-title: Proteomics – Clinical Applications
– volume: 161
  start-page: 647
  year: 2000
  end-page: 663
  article-title: Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome
  publication-title: Experimental Neurology
– volume: 17
  start-page: 860
  year: 2018
  end-page: 869
  article-title: Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: A cross‐sectional study
  publication-title: The Lancet Neurology
– volume: 12
  start-page: 7
  issue: 1
  year: 2019
  article-title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid
  publication-title: BMC Medical Genomics
– volume: 347
  start-page: 1260419
  issue: 6220
  year: 2015
  end-page: 1260419
  article-title: Tissue‐based map of the human proteome
  publication-title: Science
– volume: 262
  start-page: 9412
  year: 1987
  end-page: 9420
  article-title: Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
  publication-title: Journal of Biological Chemistry
– volume: 86
  start-page: 18
  year: 2009
  end-page: 22
  article-title: Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease
  publication-title: Experimental and Molecular Pathology
– volume: 13
  start-page: 35
  year: 2016
  end-page: 52
  article-title: Cognitive impairment, neuroimaging, and Alzheimer neuropathology in mouse models of Down syndrome
  publication-title: Current Alzheimer Research
– volume: 6
  start-page: 10
  issue: 1
  year: 2018
  article-title: Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons
  publication-title: Acta Neuropathologica Communications
– volume: 10
  start-page: 4
  year: 2018
  article-title: Autophagy and Alzheimer's disease: From molecular mechanisms to therapeutic implications
  publication-title: Frontiers in Aging Neuroscience
– volume: 78
  start-page: 103
  year: 2017
  end-page: 122
  article-title: Urine exosomes: An emerging trove of biomarkers
  publication-title: Advances in Clinical Chemistry
– volume: 82
  start-page: 85
  year: 1996
  end-page: 92
  article-title: Spatial memory deficits in segmental trisomic Ts65Dn mice
  publication-title: Behavioral Brain Research
– volume: 58
  start-page: 68
  year: 2017
  end-page: 76
  article-title: Cognitive decline and brain amyloid‐beta accumulation across 3 years in adults with Down syndrome
  publication-title: Neurobiology of Aging
– ident: e_1_2_13_17_1
  doi: 10.1038/mp.2014.127
– ident: e_1_2_13_99_1
  doi: 10.1186/s12920-019-0473-z
– ident: e_1_2_13_57_1
  doi: 10.1016/j.jalz.2011.09.229
– ident: e_1_2_13_70_1
  doi: 10.1096/fj.14-262048
– ident: e_1_2_13_91_1
  doi: 10.1016/j.biopsych.2011.08.016
– ident: e_1_2_13_136_1
  doi: 10.1038/nrn3983
– ident: e_1_2_13_101_1
  doi: 10.1016/j.ejmech.2018.08.093
– ident: e_1_2_13_84_1
  doi: 10.1016/j.yexmp.2008.10.006
– volume: 12
  start-page: 64
  year: 2014
  ident: e_1_2_13_139_1
  article-title: Mast cell exosomes promote lung adenocarcinoma cell proliferation – Role of KIT‐stem cell factor signaling
  publication-title: Cell Communication and Signaling
  contributor:
    fullname: Xiao H.
– volume: 8
  start-page: 1
  year: 2017
  ident: e_1_2_13_27_1
  article-title: Cerebrospinal fluid biomarkers for Alzheimer's disease in Down syndrome
  publication-title: Alzheimer's & Dementia
  doi: 10.1016/j.dadm.2017.02.006
  contributor:
    fullname: Dekker A. D.
– ident: e_1_2_13_47_1
  doi: 10.1212/WNL.0000000000001702
– ident: e_1_2_13_71_1
  doi: 10.1371/journal.pone.0188802
– ident: e_1_2_13_39_1
  doi: 10.1016/j.neurobiolaging.2018.10.006
– ident: e_1_2_13_65_1
  doi: 10.1073/pnas.0908953107
– ident: e_1_2_13_2_1
  doi: 10.1074/jbc.RA117.000713
– ident: e_1_2_13_89_1
  doi: 10.1080/20013078.2017.1378056
– ident: e_1_2_13_131_1
  doi: 10.1186/s13024-016-0143-y
– ident: e_1_2_13_100_1
  doi: 10.1002/biot.201600175
– ident: e_1_2_13_3_1
  doi: 10.1016/j.jalz.2015.07.490
– ident: e_1_2_13_29_1
  doi: 10.3233/JAD-160567
– volume: 3
  start-page: 63
  year: 2016
  ident: e_1_2_13_135_1
  article-title: Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile
  publication-title: Alzheimer's & Dementia
  doi: 10.1016/j.dadm.2016.04.001
  contributor:
    fullname: Winston C. N.
– ident: e_1_2_13_66_1
  doi: 10.1038/341226a0
– ident: e_1_2_13_98_1
  doi: 10.3389/fnmol.2018.00434
– ident: e_1_2_13_21_1
  doi: 10.1016/j.neurobiolaging.2017.04.006
– ident: e_1_2_13_93_1
  doi: 10.1111/nan.12084
– ident: e_1_2_13_120_1
  doi: 10.1016/bs.acc.2016.07.003
– ident: e_1_2_13_130_1
  doi: 10.1074/jbc.M609475200
– ident: e_1_2_13_83_1
  doi: 10.1006/nbdi.1996.0003
– ident: e_1_2_13_13_1
  doi: 10.3233/JAD-170773
– ident: e_1_2_13_114_1
  doi: 10.1523/JNEUROSCI.2517-15.2016
– ident: e_1_2_13_38_1
  doi: 10.3389/fimmu.2014.00525
– ident: e_1_2_13_23_1
  doi: 10.1186/s13063-016-1370-9
– ident: e_1_2_13_50_1
  doi: 10.1159/000488943
– ident: e_1_2_13_140_1
  doi: 10.4103/1673-5374.198966
– ident: e_1_2_13_87_1
  doi: 10.1093/nar/gkr828
– ident: e_1_2_13_143_1
  doi: 10.3389/fnins.2017.00229
– ident: e_1_2_13_9_1
  doi: 10.3389/fimmu.2014.00403
– ident: e_1_2_13_11_1
  doi: 10.3389/fphys.2012.00124
– ident: e_1_2_13_51_1
  doi: 10.1006/exnr.1999.7289
– ident: e_1_2_13_53_1
  doi: 10.2174/1567205012666150921095505
– ident: e_1_2_13_59_1
  doi: 10.1016/j.neurobiolaging.2017.05.019
– ident: e_1_2_13_117_1
  doi: 10.1016/j.ejpn.2018.09.004
– ident: e_1_2_13_133_1
  doi: 10.1016/j.bbadis.2015.11.007
– ident: e_1_2_13_103_1
  doi: 10.1074/jbc.M112.404467
– ident: e_1_2_13_115_1
  doi: 10.1074/jbc.M707358200
– ident: e_1_2_13_137_1
  doi: 10.1002/ajmg.1320370755
– ident: e_1_2_13_55_1
  doi: 10.1016/j.freeradbiomed.2017.08.028
– ident: e_1_2_13_62_1
  doi: 10.1001/archneur.1995.00540280065020
– ident: e_1_2_13_119_1
  doi: 10.1046/j.1471-4159.2000.741185.x
– ident: e_1_2_13_105_1
  doi: 10.1002/gps.2321
– ident: e_1_2_13_10_1
  doi: 10.1093/nar/gks832
– ident: e_1_2_13_63_1
  doi: 10.1016/j.tins.2018.03.006
– ident: e_1_2_13_109_1
  doi: 10.1073/pnas.0603838103
– ident: e_1_2_13_97_1
  doi: 10.1096/fj.201700359
– ident: e_1_2_13_64_1
  doi: 10.1016/j.jacc.2016.09.934
– ident: e_1_2_13_122_1
  doi: 10.1016/j.biomaterials.2017.10.012
– ident: e_1_2_13_129_1
  doi: 10.1007/s00249-007-0246-z
– ident: e_1_2_13_61_1
  doi: 10.2174/1567205012666151020114607
– ident: e_1_2_13_90_1
  doi: 10.1111/nan.12406
– ident: e_1_2_13_112_1
  doi: 10.1007/s10266-018-0395-9
– ident: e_1_2_13_107_1
  doi: 10.1002/dneu.22658
– ident: e_1_2_13_46_1
  doi: 10.1096/fj.201700731R
– ident: e_1_2_13_45_1
  doi: 10.1111/jir.12026
– ident: e_1_2_13_102_1
  doi: 10.1093/brain/awy289
– ident: e_1_2_13_141_1
  doi: 10.1242/jcs.215210
– ident: e_1_2_13_41_1
  doi: 10.1186/s40478-017-0466-0
– ident: e_1_2_13_144_1
  doi: 10.1016/j.febslet.2014.11.027
– ident: e_1_2_13_123_1
  doi: 10.1098/rstb.2016.0479
– ident: e_1_2_13_121_1
  doi: 10.1074/mcp.M112.027086
– ident: e_1_2_13_113_1
  doi: 10.2217/pgs-2018-0149
– ident: e_1_2_13_30_1
  doi: 10.1523/JNEUROSCI.5699-09.2010
– ident: e_1_2_13_86_1
  doi: 10.1093/cercor/bhy323
– ident: e_1_2_13_56_1
  doi: 10.1017/S1355617718000206
– ident: e_1_2_13_37_1
  doi: 10.1016/S1474-4422(18)30285-0
– ident: e_1_2_13_58_1
  doi: 10.1016/j.jalz.2014.10.007
– volume: 9
  start-page: 1
  year: 2017
  ident: e_1_2_13_80_1
  article-title: Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population
  publication-title: Alzheimer's & Dementia
  doi: 10.1016/j.dadm.2017.05.001
  contributor:
    fullname: Lao P. J.
– volume: 7
  start-page: 1327
  year: 2014
  ident: e_1_2_13_116_1
  article-title: MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer
  publication-title: OncoTargets and Therapy
  contributor:
    fullname: Salido‐Guadarrama I.
– ident: e_1_2_13_44_1
  doi: 10.1016/j.biopsych.2010.05.030
– ident: e_1_2_13_92_1
  doi: 10.1038/s41467-017-02533-w
– ident: e_1_2_13_124_1
  doi: 10.1159/000441419
– ident: e_1_2_13_35_1
  doi: 10.1002/acn3.571
– ident: e_1_2_13_4_1
  doi: 10.1016/j.pharmthera.2018.09.010
– ident: e_1_2_13_68_1
  doi: 10.1016/j.semcdb.2017.08.022
– ident: e_1_2_13_128_1
  doi: 10.1016/j.repbio.2017.09.007
– ident: e_1_2_13_26_1
  doi: 10.1186/s40478-018-0559-4
– ident: e_1_2_13_31_1
  doi: 10.1016/S0304-3940(98)00317-6
– ident: e_1_2_13_36_1
  doi: 10.1159/000442941
– ident: e_1_2_13_12_1
  doi: 10.1016/S0166-4328(02)00082-7
– volume: 78
  start-page: 128
  year: 1973
  ident: e_1_2_13_43_1
  article-title: Karyotype variation and behavior in Down's syndrome: Methodological review
  publication-title: American Journal of Mental Deficiency
  contributor:
    fullname: Gibson D.
– ident: e_1_2_13_22_1
  doi: 10.1016/j.semcdb.2015.02.007
– ident: e_1_2_13_108_1
  doi: 10.3233/JAD-170390
– ident: e_1_2_13_81_1
  doi: 10.2147/IJN.S170680
– ident: e_1_2_13_49_1
  doi: 10.1096/fj.201600756R
– ident: e_1_2_13_75_1
  doi: 10.1016/j.ceb.2014.05.004
– ident: e_1_2_13_104_1
  doi: 10.1186/s40478-018-0514-4
– ident: e_1_2_13_7_1
  doi: 10.1016/j.ceb.2011.04.008
– ident: e_1_2_13_42_1
  doi: 10.1002/ana.410320510
– ident: e_1_2_13_15_1
  doi: 10.1016/j.neurobiolaging.2004.02.027
– ident: e_1_2_13_54_1
  doi: 10.1016/j.jalz.2016.08.012
– ident: e_1_2_13_69_1
  doi: 10.1074/jbc.M111.253971
– ident: e_1_2_13_72_1
  doi: 10.1093/bioinformatics/btu741
– ident: e_1_2_13_126_1
  doi: 10.3389/fnagi.2018.00004
– ident: e_1_2_13_77_1
  doi: 10.1152/ajpcell.00169.2015
– ident: e_1_2_13_28_1
  doi: 10.1016/S0166-4328(97)81111-4
– ident: e_1_2_13_138_1
  doi: 10.1111/j.1365-2141.1967.tb08741.x
– volume: 8
  start-page: 2165
  year: 2018
  ident: e_1_2_13_40_1
  article-title: Exosomes in cancer therapy: A novel experimental strategy
  publication-title: American Journal of Cancer Research
  contributor:
    fullname: Gao D.
– ident: e_1_2_13_79_1
  doi: 10.3389/fphys.2012.00228
– ident: e_1_2_13_14_1
  doi: 10.1083/jcb.200508014
– ident: e_1_2_13_52_1
  doi: 10.1080/14789450.2018.1537788
– ident: e_1_2_13_16_1
  doi: 10.1136/sextrans-2018-053813
– ident: e_1_2_13_134_1
  doi: 10.3233/JAD-180776
– ident: e_1_2_13_95_1
  doi: 10.1111/jir.12342
– ident: e_1_2_13_118_1
  doi: 10.1016/j.neurobiolaging.2015.06.020
– ident: e_1_2_13_20_1
  doi: 10.1016/j.freeradbiomed.2017.10.001
– ident: e_1_2_13_78_1
  doi: 10.1016/j.mcn.2010.11.004
– ident: e_1_2_13_5_1
  doi: 10.4132/jptm.2017.05.21
– ident: e_1_2_13_96_1
  doi: 10.1016/j.nicl.2017.10.022
– ident: e_1_2_13_127_1
  doi: 10.1126/science.1260419
– ident: e_1_2_13_24_1
  doi: 10.1016/j.bbr.2009.08.034
– volume: 7
  start-page: 135
  year: 1996
  ident: e_1_2_13_132_1
  article-title: Differential susceptibility to neurofibrillary pathology among patients with Down syndrome
  publication-title: Dementia
  contributor:
    fullname: Wegiel J.
– ident: e_1_2_13_142_1
  doi: 10.1080/15476286.2015.1100795
– ident: e_1_2_13_6_1
  doi: 10.1111/jcmm.12834
– ident: e_1_2_13_25_1
  doi: 10.1021/acs.molpharmaceut.8b00901
– ident: e_1_2_13_48_1
  doi: 10.1096/fj.201802319R
– ident: e_1_2_13_67_1
  doi: 10.1016/S0021-9258(18)48095-7
– ident: e_1_2_13_74_1
  doi: 10.1111/desc.12468
– ident: e_1_2_13_125_1
  doi: 10.1016/j.jacc.2016.08.073
– ident: e_1_2_13_94_1
  doi: 10.1186/alzrt213
– ident: e_1_2_13_34_1
  doi: 10.1016/j.jalz.2014.06.008
– ident: e_1_2_13_145_1
  doi: 10.1093/biosci/biv084
– ident: e_1_2_13_76_1
  doi: 10.1002/prca.200700522
– ident: e_1_2_13_8_1
  doi: 10.1186/s13287-015-0116-z
– ident: e_1_2_13_60_1
  doi: 10.1093/jnen/62.9.917
– ident: e_1_2_13_111_1
  doi: 10.1038/ng1095-177
– ident: e_1_2_13_85_1
  doi: 10.1249/MSS.0000000000001672
– ident: e_1_2_13_32_1
  doi: 10.1111/j.1600-0854.2007.00677.x
– ident: e_1_2_13_19_1
  doi: 10.3389/fphys.2012.00145
– ident: e_1_2_13_18_1
  doi: 10.1016/j.jprot.2014.04.028
– ident: e_1_2_13_88_1
  doi: 10.1016/S0304-3940(97)00966-X
– ident: e_1_2_13_73_1
  doi: 10.1186/1471-2407-12-421
– ident: e_1_2_13_106_1
  doi: 10.2217/bmm.13.63
– ident: e_1_2_13_110_1
  doi: 10.1083/jcb.201211138
– ident: e_1_2_13_82_1
  doi: 10.1158/0008-5472.CAN-07-6538
– ident: e_1_2_13_33_1
  doi: 10.1016/j.mcn.2005.12.003
SSID ssj0053260
Score 2.4012053
SecondaryResourceType review_article
Snippet Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have...
Abstract Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention...
Down syndrome (DS) is a multisystem disorder affecting one in 800 births worldwide. Advancing technology, medical treatment, and social intervention have...
SourceID pubmedcentral
proquest
crossref
pubmed
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 639
SubjectTerms Aging
Alzheimer's disease
Animals
biomarkers
Cell Communication - physiology
Cell interactions
Cell signaling
Complications
Down syndrome
Down Syndrome - diagnosis
Down Syndrome - metabolism
Down's syndrome
Endocytosis - physiology
Exosomes
Exosomes - metabolism
Exosomes - pathology
extracellular vesicles
Extracellular Vesicles - metabolism
Extracellular Vesicles - pathology
Humans
Life span
Medical treatment
Neurodegeneration
Neurodegenerative diseases
Neurological diseases
Secretion
Vesicles
Title Exosome release and cargo in Down syndrome
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fdneu.22712
https://www.ncbi.nlm.nih.gov/pubmed/31347291
https://www.proquest.com/docview/2295350275
https://search.proquest.com/docview/2265746025
https://pubmed.ncbi.nlm.nih.gov/PMC7388580
Volume 79
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fSxwxEB7Ep75UrW1da0tKSx-EPXeTzWYDfZF6IoX6IB74UpZsfughZot3B-pf30n2du1VENqXZSFZNslkMt8kk28APhtRalpKmYrc8LRgiqZSaXw0wmSlYjmN0e4_TsuTSfH9gl-swdf-LkzHDzFsuAXNiOt1UHDVzA4eSUONt4sRpSKmGA5MegERnQ3cURxxSdYdKaPKFzwfuEnpweOnq9boCcR8Gin5J4KNJuh4A372je8iT65Hi3kz0g9_8Tr-b-824eUSm5LDbjJtwZr1r2D70KNffnNPvpAYLRq34bdhf3zXztobS0LSFbSERHlDtLq9bMnUkyP07UlPhvAaJsfj828n6TLvQqrRWaOpptZwxypdZSoXyuROW6e0Zs5l1LmS5bxBr8e4CosqtPcybC3nphGKO3Qx2RtY9623O0C0oUY6q5tC4pKsWaUKjZiEaYlIwRiZwKd-_OtfHb1G3REp0zoMQR2HIIG9XjT1UsVmdchDzng4dU3g41CMyhFOPJS37SLUKbkoSsR1CbztJDn8hoVLtFTmCYgVGQ8VAvH2aomfXkUCbsGw11WWwH4U4TMtr49Ox5P4tvsvld_BCwRmsgsL3oP1-e3CvkfwM28-xEn-G32_AAo
link.rule.ids 230,315,786,790,891,1382,27955,27956,46327,46751
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6hcigXHm2BQKFGrThUyjax4zg-VuxWC7R7qLpSb5HjB1SoDuruSsCvZ-zspiyVkMolimRHiT2ezDfj8TcAB0aUmpZSpiI3PC2YoqlUGi-NMFmpWE5jtvvZpBxPi0-X_HKZmxPOwnT8EH3ALWhG_F8HBQ8B6aNb1lDj7WJAqQg1hh-ivvOgl8Pznj2KIzLJuk1lVPqC5z07KT26fXbdHt0BmXdzJf_EsNEInTzpKq3OIndhyD35NljMm4H-9Rez43-P7yk8XsJTctytp2fwwPot2D726Jpf_yTvSUwYjZH4bTgc_Whn7bUloe4KGkOivCFa3XxpyZUnQ3TvyYoPYQemJ6OLD-N0WXoh1eiv0VRTa7hjla4ylQtlcqetU1oz5zLqXMly3qDjY1yFTRWafBmiy7lphOIOvUz2HDZ86-1LINpQI53VTSHxr6xZpQqNsIRpiWDBGJnA_koA9feOYaPuuJRpHaagjlOQwO5KNvVSy2Z1KEXOeNh4TeBd34z6ETY9lLftIvQpuShKhHYJvOhE2b-GhXO0VOYJiDUh9x0C9_Z6i7_6Gjm4BcNRV1kCh1GG__jyejgZTePdq_t03oPN8cXZaX36cfL5NTxCnCa7LOFd2JjfLOwbxELz5m1c8b8BfPMEKg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3daxQxEB9KBfFFrfVjtdWI4kNhr7vJZrMBX4p3R_06RDzoiyzZfGiRZkt7B7Z_vZPs7dazIOjLspAsm2Qymd8kk98AvDSi1LSUMhW54WnBFE2l0vhohMlKxXIao90_zsrDefHuiB9twOv-LkzHDzFsuAXNiOt1UPBT4_avSEONt8sRpSKkGL5RlIwG12v8eSCP4ghMsu5MGXW-4PlATkr3r75dN0fXMOb1UMnfIWy0QdM78LVvfRd68mO0XDQjffkHseP_du8u3F6BU3LQzaYt2LD-HmwfeHTMTy7IKxLDReM-_DbsTX625-2JJSHrCppCorwhWp19a8mxJ2N07knPhnAf5tPJlzeH6SrxQqrRW6OpptZwxypdZSoXyuROW6e0Zs5l1LmS5bxBt8e4CosqNPgy7C3nphGKO_Qx2QPY9K23j4BoQ410VjeFxDVZs0oVGkEJ0xKhgjEygRf9-NenHb9G3TEp0zoMQR2HIIGdXjT1SsfO65CInPFw7JrA86EYtSMceShv22WoU3JRlAjsEnjYSXL4DQu3aKnMExBrMh4qBObt9RJ__D0ycAuGva6yBPaiCP_S8no8m8zj2-N_qfwMbn4aT-sPb2fvn8AtBGmyCxHegc3F2dLuIhBaNE_jfP8FdpwC2Q
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=EXOSOME+RELEASE+AND+CARGO+IN+DOWN+SYNDROME&rft.jtitle=Developmental+neurobiology+%28Hoboken%2C+N.J.%29&rft.au=Hamlett%2C+Eric+D.&rft.au=LaRosa%2C+Angela&rft.au=Mufson%2C+Elliott+J.&rft.au=Fortea%2C+Juan&rft.date=2019-07-01&rft.issn=1932-8451&rft.eissn=1932-846X&rft.volume=79&rft.issue=7&rft.spage=639&rft.epage=655&rft_id=info:doi/10.1002%2Fdneu.22712&rft_id=info%3Apmid%2F31347291&rft.externalDBID=PMC7388580
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-8451&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-8451&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-8451&client=summon