Exosome release and cargo in Down syndrome
Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the abili...
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Published in | Developmental neurobiology (Hoboken, N.J.) Vol. 79; no. 7; pp. 639 - 655 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Wiley Subscription Services, Inc
01.07.2019
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Abstract | Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the ability to capture extracellular vesicles (EVs) in blood from specific cell types allows for the investigation of novel intracellular processes. Exosomes are one type of EVs that have demonstrated great potential in uncovering new biomarkers of neurodegeneration and disease, and also that appear to be intricately involved in the transsynaptic spread of pathogenic factors underlying Alzheimer's disease and other neurological diseases. Exosomes are nanosized vesicles, generated in endosomal multivesicular bodies (MVBs) and secreted by most cells in the body. Since exosomes are important mediators of intercellular communication and genetic exchange, they have emerged as a major research focus and have revealed novel biological sequelae involved in conditions afflicting the DS population. This review summarizes current knowledge on exosome biology in individuals with DS, both early in life and in aging individuals. Collectively these studies have demonstrated that complex multicellular processes underlying DS etiologies may include abnormal formation and secretion of extracellular vesicles such as exosomes. |
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AbstractList | Down syndrome (DS) is a multisystem disorder affecting one in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the ability to capture extracellular vesicles (EVs) in blood from specific cell types allows for the investigation of novel intracellular processes. Exosomes are one type of EVs that have demonstrated great potential in uncovering new biomarkers of neurodegeneration and disease, and also that appear to be intricately involved in the transsynaptic spread of pathogenic factors underlying Alzheimer’s disease (AD) and other neurological diseases. Exosomes are nanosized vesicles, generated in endosomal multivesicular bodies (MVBs) and secreted by most cells in the body. Since exosomes are important mediators of intercellular communication and genetic exchange, they have emerged as a major research focus and have revealed novel biological sequelae involved in conditions afflicting the DS population. This review summarizes current knowledge on exosome biology in individuals with DS, both early in life and in aging individuals. Collectively these studies have demonstrated that complex multicellular processes underlying DS etiologies may include abnormal formation and secretion of extracellular vesicles such as exosomes. Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the ability to capture extracellular vesicles (EVs) in blood from specific cell types allows for the investigation of novel intracellular processes. Exosomes are one type of EVs that have demonstrated great potential in uncovering new biomarkers of neurodegeneration and disease, and also that appear to be intricately involved in the transsynaptic spread of pathogenic factors underlying Alzheimer's disease and other neurological diseases. Exosomes are nanosized vesicles, generated in endosomal multivesicular bodies (MVBs) and secreted by most cells in the body. Since exosomes are important mediators of intercellular communication and genetic exchange, they have emerged as a major research focus and have revealed novel biological sequelae involved in conditions afflicting the DS population. This review summarizes current knowledge on exosome biology in individuals with DS, both early in life and in aging individuals. Collectively these studies have demonstrated that complex multicellular processes underlying DS etiologies may include abnormal formation and secretion of extracellular vesicles such as exosomes. Abstract Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the ability to capture extracellular vesicles (EVs) in blood from specific cell types allows for the investigation of novel intracellular processes. Exosomes are one type of EVs that have demonstrated great potential in uncovering new biomarkers of neurodegeneration and disease, and also that appear to be intricately involved in the transsynaptic spread of pathogenic factors underlying Alzheimer's disease and other neurological diseases. Exosomes are nanosized vesicles, generated in endosomal multivesicular bodies (MVBs) and secreted by most cells in the body. Since exosomes are important mediators of intercellular communication and genetic exchange, they have emerged as a major research focus and have revealed novel biological sequelae involved in conditions afflicting the DS population. This review summarizes current knowledge on exosome biology in individuals with DS, both early in life and in aging individuals. Collectively these studies have demonstrated that complex multicellular processes underlying DS etiologies may include abnormal formation and secretion of extracellular vesicles such as exosomes. |
Author | Hamlett, Eric D. Mufson, Elliott J. Fortea, Juan Ledreux, Aurélie LaRosa, Angela Granholm, Ann‐Charlotte |
AuthorAffiliation | 6 Department of Biological Sciences and the Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208 4 Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, CIBERNED, Universitat Autònoma de Barcelona, Barcelona, Spain 1 Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425 2 Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425 3 Barrow Neurological Institute, Phoenix, AZ, 85013 5 Alzheimer’s Disease and Other Cognitive Disorders Unit, Department of Neurology, Hospital Clínic, Institut d’Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Barcelona, Spain |
AuthorAffiliation_xml | – name: 6 Department of Biological Sciences and the Knoebel Institute for Healthy Aging, University of Denver, Denver, CO 80208 – name: 3 Barrow Neurological Institute, Phoenix, AZ, 85013 – name: 5 Alzheimer’s Disease and Other Cognitive Disorders Unit, Department of Neurology, Hospital Clínic, Institut d’Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Barcelona, Spain – name: 4 Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, CIBERNED, Universitat Autònoma de Barcelona, Barcelona, Spain – name: 1 Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425 – name: 2 Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425 |
Author_xml | – sequence: 1 givenname: Eric D. orcidid: 0000-0002-2900-7949 surname: Hamlett fullname: Hamlett, Eric D. email: hamlette@musc.edu organization: Medical University of South Carolina – sequence: 2 givenname: Angela surname: LaRosa fullname: LaRosa, Angela organization: Medical University of South Carolina – sequence: 3 givenname: Elliott J. surname: Mufson fullname: Mufson, Elliott J. organization: Barrow Neurological Institute – sequence: 4 givenname: Juan surname: Fortea fullname: Fortea, Juan organization: University of Barcelona – sequence: 5 givenname: Aurélie surname: Ledreux fullname: Ledreux, Aurélie organization: University of Denver – sequence: 6 givenname: Ann‐Charlotte surname: Granholm fullname: Granholm, Ann‐Charlotte organization: University of Denver |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31347291$$D View this record in MEDLINE/PubMed |
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Snippet | Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have... Abstract Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention... Down syndrome (DS) is a multisystem disorder affecting one in 800 births worldwide. Advancing technology, medical treatment, and social intervention have... |
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SubjectTerms | Aging Alzheimer's disease Animals biomarkers Cell Communication - physiology Cell interactions Cell signaling Complications Down syndrome Down Syndrome - diagnosis Down Syndrome - metabolism Down's syndrome Endocytosis - physiology Exosomes Exosomes - metabolism Exosomes - pathology extracellular vesicles Extracellular Vesicles - metabolism Extracellular Vesicles - pathology Humans Life span Medical treatment Neurodegeneration Neurodegenerative diseases Neurological diseases Secretion Vesicles |
Title | Exosome release and cargo in Down syndrome |
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