P53 suppresses the progression of hepatocellular carcinoma via miR‐15a by decreasing OGT expression and EZH2 stabilization

• Published in: Journal of cellular and molecular medicine Vol. 25; no. 19; pp. 9168 - 9182
• Main Authors: You, Zhenyu, Peng, Dandan, Cao, Yixin, Zhu, Yuanzhe, Yin, Jianjun, Zhang, Guangxing, Peng, Xiaodong
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2021; John Wiley and Sons Inc
• Subjects: Animals; Apoptosis; Bioinformatics; Biomarkers, Tumor; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - therapy; Cell cycle; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation; Cycloheximide; Disease Models, Animal; Disease Progression; Enhancer of Zeste Homolog 2 Protein - metabolism; EZH2; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hepatitis B; Hepatocellular carcinoma; Heterografts; Humans; Liver cancer; Mice; MicroRNAs - genetics; miRNA; miR‐15a; Mutation; N-Acetylglucosamine; N-Acetylglucosaminyltransferases - metabolism; OGT; Original; O‐GlcNAc; P53; p53 Protein; Plasmids; Prognosis; Tumor Suppressor Protein p53 - metabolism; Tumors; miR-15a; O-GlcNAc; OGT; hepatocellular carcinoma; EZH2; P53

Existing literature has highlighted the tumour suppressive capacity of microRNA‐15a (miR‐15a); however, its role in hepatocellular carcinoma (HCC) remains relatively unknown. This study aimed to investigate the role of miR‐15a in HCC and the associated underlying mechanism. Initially, RT‐qPCR was pe...