Adipose‐derived stem cell spheroids are superior to single‐cell suspensions to improve fat autograft long‐term survival

• Published in: Journal of cellular and molecular medicine Vol. 26; no. 5; pp. 1421 - 1433
• Main Authors: El Harane, Sanae, Durual, Stéphane, Braschler, Thomas, André‐Lévigne, Dominik, Brembilla, Nicolo, Krause, Karl‐Heinz, Modarressi, Ali, Preynat‐Seauve, Olivier
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2022; John Wiley and Sons Inc
• Subjects: Adipocytes; Adipose Tissue - metabolism; adipose‐derived stem cells; Animal models; Animals; Autografts; Autophagy; Cell suspensions; fat transplantation; Gene expression; Original; Peptides; Proteomes; Reconstructive surgery; regenerative medicine; Software; Spheroids; Stem cell transplantation; Stem Cells; Suspensions; Tissue engineering; adipose-derived stem cells; fat transplantation; spheroids; regenerative medicine

Autologous fat transplantation is a widely used procedure for surgical reconstruction of tissues. The resorption rate of this transplantation remains high and unpredictable, reinforcing the need of adjuvant treatments that increase the long‐term stability of grafts. Adipose‐derived stem cells (ASC)...