Diagnostic and therapeutic value of progastrin‐releasing peptide on small‐cell lung cancer: A Single‐Center Experience in China

• Published in: Journal of cellular and molecular medicine Vol. 22; no. 9; pp. 4328 - 4334
• Main Authors: Wu, Xiao‐Yuan, Hu, Yang‐Bo, Li, Hui‐Juan, Wan, Bing, Zhang, Chen‐Xi, Zhang, Bin, Hu, Huan, Zhang, Qun, Lv, Tang‐Feng, Zhan, Ping, Song, Yong
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.09.2018; John Wiley and Sons Inc
• Subjects: Adult; Aged; Antineoplastic Agents - therapeutic use; Area Under Curve; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Carcinoma, Non-Small-Cell Lung - blood; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - pathology; Chemotherapy; China; diagnosis; Diagnosis, Differential; Efficiency; Female; Follow-Up Studies; Humans; Lesions; Lung cancer; Lung diseases; Lung Neoplasms - blood; Lung Neoplasms - diagnosis; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Male; Middle Aged; Neoplasms - blood; Neoplasms - diagnosis; Neoplasms - pathology; neuron‐specific enolase; Non-small cell lung carcinoma; Original; Patients; Peptide Fragments - blood; Peptide Fragments - genetics; Phosphopyruvate Hydratase - blood; Phosphopyruvate Hydratase - genetics; progastrin‐releasing peptide; Recombinant Proteins - blood; Recombinant Proteins - genetics; Retrospective Studies; Sensitivity and Specificity; Small cell lung carcinoma; Small Cell Lung Carcinoma - blood; Small Cell Lung Carcinoma - diagnosis; Small Cell Lung Carcinoma - drug therapy; Small Cell Lung Carcinoma - pathology; small‐cell lung cancer; therapeutic monitoring; China; diagnosis; neuron-specific enolase; small-cell lung cancer; progastrin-releasing peptide; therapeutic monitoring

We aimed to compare the diagnostic efficiency of proGRP and NSE on SCLC and to investigate whether the change of proGRP level would predict therapeutic response. Patients who were firstly diagnosed pathologically in Nanjing Chest Hospital and measured proGRP level consecutively were enrolled in the...