The cellular function and molecular mechanism of formaldehyde in cardiovascular disease and heart development

• Published in: Journal of cellular and molecular medicine Vol. 25; no. 12; pp. 5358 - 5371
• Main Authors: Zhang, Ying, Yang, Yanyan, He, Xiangqin, Yang, Panyu, Zong, Tingyu, Sun, Pin, Sun, Rui‐cong, Yu, Tao, Jiang, Zhirong
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.06.2021; John Wiley and Sons Inc
• Subjects: Aldehydes; Alzheimer's disease; Animals; Apoptosis; Arrhythmia; Arteriosclerosis; Atherosclerosis; Body fluids; Carbon; Cardiac arrhythmia; Cardiomyocytes; cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - chemically induced; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - pathology; Cardiovascular system; Congenital diseases; Congestive heart failure; Coronary artery disease; Cytotoxicity; Deamination; Dehydrogenases; Developmental stages; Disinfectants - adverse effects; DNA methylation; Embryogenesis; Endothelial cells; Enzymes; Female; Formaldehyde; Formaldehyde - adverse effects; Fruits; Heart; heart development; Homocysteine; Humans; Metabolism; Methylamine; Myocardial infarction; Oxidative stress; Physiology; Pollutants; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - metabolism; Prenatal Exposure Delayed Effects - pathology; Review; Reviews; Semicarbazide; semicarbazide‐sensitive amine oxidase; Sinuses; Smooth muscle; Vegetables; Vitamin B; atherosclerosis; cardiovascular disease; heart development; semicarbazide-sensitive amine oxidase; formaldehyde

As a common air pollutant, formaldehyde is widely present in nature, industrial production and consumer products. Endogenous formaldehyde is mainly produced through the oxidative deamination of methylamine catalysed by semicarbazide‐sensitive amine oxidase (SSAO) and is ubiquitous in human body flui...