Optimal design of polymer-based microneedle for improved collection of whole blood from human fingers
A highly applicable theoretical model and a simple, inexpensive mould-based method is introduced to design and fabricate the pyramid-shaped SU-8 microneedle. The main purpose is to be able to extract blood at point-of-care sites from up to 80% of typical nurse-home patients with a disorder of blood...
Saved in:
| Published in | Micro & nano letters Vol. 9; no. 10; pp. 644 - 649 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Stevenage
The Institution of Engineering and Technology
01.10.2014
John Wiley & Sons, Inc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | A highly applicable theoretical model and a simple, inexpensive mould-based method is introduced to design and fabricate the pyramid-shaped SU-8 microneedle. The main purpose is to be able to extract blood at point-of-care sites from up to 80% of typical nurse-home patients with a disorder of blood circulation in fingers and toes (Raynaud's phenomenon). Geometry optimisation was conducted based on the study of fracture force, which can be accurately predicted by the proposed theoretical model. The accuracy of the proposed theoretical model was confirmed by the finite element study and practical measurement. For practical verification, measurement of fracture force was conducted on fabricated SU-8 microneedles, including a 1470 µm-tall pyramid-shaped microneedle and a 1515 µm-tall traditional-shaped microneedle. The measurement results confirmed the improved strength of the proposed pyramid-shaped microneedle, especially of the pyramidal tips, which can exhibit significantly higher applied force with 2.82 N compared with the 0.51 N bevel tip. Practical tests of skin penetrability on human fingers showed that the microneedles fabricated with the proposed geometry may be sharp and strong enough to safely puncture human skin and long enough to reach the blood vessels. |
|---|---|
| AbstractList | A highly applicable theoretical model and a simple, inexpensive mould-based method is introduced to design and fabricate the pyramid-shaped SU-8 microneedle. The main purpose is to be able to extract blood at point-of-care sites from up to 80% of typical nurse-home patients with a disorder of blood circulation in fingers and toes (Raynaud's phenomenon). Geometry optimisation was conducted based on the study of fracture force, which can be accurately predicted by the proposed theoretical model. The accuracy of the proposed theoretical model was confirmed by the finite element study and practical measurement. For practical verification, measurement of fracture force was conducted on fabricated SU-8 microneedles, including a 1470 µm-tall pyramid-shaped microneedle and a 1515 µm-tall traditional-shaped microneedle. The measurement results confirmed the improved strength of the proposed pyramid-shaped microneedle, especially of the pyramidal tips, which can exhibit significantly higher applied force with 2.82 N compared with the 0.51 N bevel tip. Practical tests of skin penetrability on human fingers showed that the microneedles fabricated with the proposed geometry may be sharp and strong enough to safely puncture human skin and long enough to reach the blood vessels. A highly applicable theoretical model and a simple, inexpensive mould‐based method is introduced to design and fabricate the pyramid‐shaped SU‐8 microneedle. The main purpose is to be able to extract blood at point‐of‐care sites from up to 80% of typical nurse‐home patients with a disorder of blood circulation in fingers and toes (Raynaud's phenomenon). Geometry optimisation was conducted based on the study of fracture force, which can be accurately predicted by the proposed theoretical model. The accuracy of the proposed theoretical model was confirmed by the finite element study and practical measurement. For practical verification, measurement of fracture force was conducted on fabricated SU‐8 microneedles, including a 1470 µm‐tall pyramid‐shaped microneedle and a 1515 µm‐tall traditional‐shaped microneedle. The measurement results confirmed the improved strength of the proposed pyramid‐shaped microneedle, especially of the pyramidal tips, which can exhibit significantly higher applied force with 2.82 N compared with the 0.51 N bevel tip. Practical tests of skin penetrability on human fingers showed that the microneedles fabricated with the proposed geometry may be sharp and strong enough to safely puncture human skin and long enough to reach the blood vessels. A highly applicable theoretical model and a simple, inexpensive mould-based method is introduced to design and fabricate the pyramid-shaped SU-8 microneedle. The main purpose is to be able to extract blood at point-of-care sites from up to 80% of typical nurse-home patients with a disorder of blood circulation in fingers and toes (Raynaud's phenomenon). Geometry optimisation was conducted based on the study of fracture force, which can be accurately predicted by the proposed theoretical model. The accuracy of the proposed theoretical model was confirmed by the finite element study and practical measurement. For practical verification, measurement of fracture force was conducted on fabricated SU-8 microneedles, including a 1470 mu m-tall pyramid-shaped microneedle and a 1515 mu m-tall traditional-shaped microneedle. The measurement results confirmed the improved strength of the proposed pyramid-shaped microneedle, especially of the pyramidal tips, which can exhibit significantly higher applied force with 2.82 N compared with the 0.51 N bevel tip. Practical tests of skin penetrability on human fingers showed that the microneedles fabricated with the proposed geometry may be sharp and strong enough to safely puncture human skin and long enough to reach the blood vessels. |
| Author | Karlsen, Frank Tran-Minh, Nhut Le Thanh, Hoa Nguyen, Vy Le The, Hai Wang, Kaiying |
| Author_xml | – sequence: 1 givenname: Hoa surname: Le Thanh fullname: Le Thanh, Hoa email: thanhhoa.hcmut@gmail.com organization: Department of Micro and Nano Systems Technology (IMST), Buskerud and Vestfold University College, Postboks 235, 3603 Kongsberg, Norway – sequence: 2 givenname: Hai surname: Le The fullname: Le The, Hai organization: Department of Micro and Nano Systems Technology (IMST), Buskerud and Vestfold University College, Postboks 235, 3603 Kongsberg, Norway – sequence: 3 givenname: Vy surname: Nguyen fullname: Nguyen, Vy organization: Department of Micro and Nano Systems Technology (IMST), Buskerud and Vestfold University College, Postboks 235, 3603 Kongsberg, Norway – sequence: 4 givenname: Nhut surname: Tran-Minh fullname: Tran-Minh, Nhut organization: Department of Micro and Nano Systems Technology (IMST), Buskerud and Vestfold University College, Postboks 235, 3603 Kongsberg, Norway – sequence: 5 givenname: Kaiying surname: Wang fullname: Wang, Kaiying organization: Department of Micro and Nano Systems Technology (IMST), Buskerud and Vestfold University College, Postboks 235, 3603 Kongsberg, Norway – sequence: 6 givenname: Frank surname: Karlsen fullname: Karlsen, Frank organization: Department of Micro and Nano Systems Technology (IMST), Buskerud and Vestfold University College, Postboks 235, 3603 Kongsberg, Norway |
| BookMark | eNp90EtPxCAUBWBiNPG5dE9iTHTR8UJpaZc68ZWMunFPaHtRDC0VZjTz72UcFxNjXEHCd-Fw9sn24Ack5JjBhIGoL_rBTTgwMQEu-BbZY7KADITItzf2u2Q_xjcAIbms9wg-jXPba0c7jPZloN7Q0btljyFrdMSO9rYN6RnsHFLjA7X9GPxHOmi9c9jOrf8e-nz1CTTO-46a4Hv6uuj1QI0dXjDEQ7JjtIt49LMekOeb6-fpXTZ7ur2fXs6yVoiKZ3mjc9FwXZe5EEwaLmRRpR8VdSkAsS6bVrMca9RMNKaSLK-EQWhN15i6avMDcra-NkV8X2Ccq97GFp3TA_pFVKwsAWRecJnoyS_65hdhSOGSElDKooYiqWytUgcxBjRqDKmtsFQM1KpzlTpXq87VqvPky7X_tA6X_2P18HjJr24ACr4aPF0PWtxI8vA42_BjZ5I7_8P9HeYLtBigOA |
| CitedBy_id | crossref_primary_10_1007_s11042_016_3300_y crossref_primary_10_3390_mi14030615 crossref_primary_10_3390_mi15050619 crossref_primary_10_1016_j_apmt_2018_08_013 crossref_primary_10_1016_j_biomaterials_2019_119740 crossref_primary_10_1109_JMEMS_2015_2424926 |
| Cites_doi | 10.1007/s00542‐009‐0883‐5 10.1089/152091501300209606 10.1146/annurev.bioeng.2.1.289 10.1016/j.sna.2003.11.008 10.1088/0960‐1317/7/3/010 10.1023/A:1009907306184 10.1007/s10544‐005‐6077‐8 10.1088/0960‐1317/14/4/021 10.1109/JMEMS.2007.899339 10.1016/S0142‐9612(02)00565‐3 10.1007/s10544‐012‐9683‐2 10.1201/b11377 10.1088/0960‐1317/16/5/012 10.1109/JSEN.2008.2006261 10.1109/NEMS.2014.6908843 10.1109/TBME.2005.845240 10.1117/1.2117108 10.1088/0960‐1317/20/6/064006 |
| ContentType | Journal Article |
| Copyright | The Institution of Engineering and Technology 2014 The Institution of Engineering and Technology Copyright The Institution of Engineering & Technology Oct 2014 |
| Copyright_xml | – notice: The Institution of Engineering and Technology – notice: 2014 The Institution of Engineering and Technology – notice: Copyright The Institution of Engineering & Technology Oct 2014 |
| DBID | AAYXX CITATION 7TB 7U5 8FD F28 FR3 L7M 7SR JG9 |
| DOI | 10.1049/mnl.2014.0242 |
| DatabaseName | CrossRef Mechanical & Transportation Engineering Abstracts Solid State and Superconductivity Abstracts Technology Research Database ANTE: Abstracts in New Technology & Engineering Engineering Research Database Advanced Technologies Database with Aerospace Engineered Materials Abstracts Materials Research Database |
| DatabaseTitle | CrossRef Solid State and Superconductivity Abstracts Engineering Research Database Technology Research Database Mechanical & Transportation Engineering Abstracts Advanced Technologies Database with Aerospace ANTE: Abstracts in New Technology & Engineering Materials Research Database Engineered Materials Abstracts |
| DatabaseTitleList | Solid State and Superconductivity Abstracts Materials Research Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering |
| EISSN | 1750-0443 |
| EndPage | 649 |
| ExternalDocumentID | 3538298401 10_1049_mnl_2014_0242 MNA2BF00522 |
| Genre | shortCommunication Feature |
| GroupedDBID | - 0R 123 24P 29M 4.4 6IK 8FE 8FG AAJGR ABJCF ACGFS ACIWK AENEX AFKRA ALMA_UNASSIGNED_HOLDINGS ARAPS BENPR BFFAM BGLVJ CS3 D1I DU5 EBS EJD F5P HCIFZ HZ IFIPE IPLJI JAVBF KB. L6V LAI LOTEE LXI LXU M43 M7S NADUK NXXTH O9- OCL P2P P62 PDBOC PTHSS RIE RIG RNS RUI S0W UNMZH UNR --- 0R~ 0ZK 1OC AAHHS AAHJG ABMDY ABQXS ACCFJ ACESK ACXQS ADEYR AEEZP AEQDE AIWBW AJBDE ALUQN AVUZU CCPQU GROUPED_DOAJ HZ~ IAO IFBGX IGS IHR INH MCNEO M~E OK1 ROL AAYXX CITATION 7TB 7U5 8FD F28 FR3 L7M 7SR JG9 |
| ID | FETCH-LOGICAL-c4482-3ba34b2a9634417f2475820159640ee96bca13e9ea14bf871384fe0cfdbf98c3 |
| IEDL.DBID | 24P |
| ISSN | 1750-0443 |
| IngestDate | Fri Aug 16 21:02:37 EDT 2024 Fri Sep 13 10:14:03 EDT 2024 Fri Aug 23 02:16:18 EDT 2024 Sat Aug 24 01:04:44 EDT 2024 Tue Jan 05 21:53:10 EST 2021 Thu May 09 18:25:59 EDT 2019 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | needles inexpensive mould-based method force measurement skin size 1470 mum finite element study fracture blood circulation biomedical measurement nurse-home patients Raynaud phenomenon practical verification polymers whole blood extraction point-of-care sites safely puncture human skin skin penetrability human fingers practical measurement blood vessels finite element analysis blood haemorheology fracture force measurement optimal design geometry optimisation size 1515 mum pyramid-shaped SU-8 microneedle haemodynamics |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4482-3ba34b2a9634417f2475820159640ee96bca13e9ea14bf871384fe0cfdbf98c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1049/mnl.2014.0242 |
| PQID | 1640675905 |
| PQPubID | 1916337 |
| PageCount | 6 |
| ParticipantIDs | proquest_journals_1640675905 crossref_primary_10_1049_mnl_2014_0242 iet_journals_10_1049_mnl_2014_0242 proquest_miscellaneous_1660073527 wiley_primary_10_1049_mnl_2014_0242_MNA2BF00522 |
| ProviderPackageCode | RUI |
| PublicationCentury | 2000 |
| PublicationDate | 20141000 October 2014 2014-10-00 20141001 |
| PublicationDateYYYYMMDD | 2014-10-01 |
| PublicationDate_xml | – month: 10 year: 2014 text: 20141000 |
| PublicationDecade | 2010 |
| PublicationPlace | Stevenage |
| PublicationPlace_xml | – name: Stevenage |
| PublicationTitle | Micro & nano letters |
| PublicationYear | 2014 |
| Publisher | The Institution of Engineering and Technology John Wiley & Sons, Inc |
| Publisher_xml | – name: The Institution of Engineering and Technology – name: John Wiley & Sons, Inc |
| References | Kim, K.; Park, D.S.; Lu, H.M.; Che, W.; Kim, K.; Lee, J.B.; Ahn, C.H. (C13) 2004; 14 McAllister, D.V.; Allen, M.G.; Prausnitz, M.R. (C1) 2002; 2 Kim, K.; Park, D.S.; Lu, H.M.; Che, W.; Kim, K.; Lee, J.B.; Ahn, C.H. (C8) 2004; 14 Li, B.; Liu, M.; Chen, Q. (C22) 2005; 4 Zhang, P.; Dalton, C.; Jullien, G.A. (C4) 2009; 15 Cho, S.H.; Lu, H.M.; Cauller, L.; Romero-Ortega, M.I.; Lee, J.B.; Hughes, G.A. (C18) 2008; 8 Kuo, S.C.; Chou, Y. (C7) 2004; 7 Ji, J.; Tay, F.E.; Miao, J.; Iliescu, C. (C11) 2006; 16 Lorenz, H.; Despont, M.; Fahrni, N.; LaBianca, N.; Renaud, P.; Vettiger, P. (C16) 1997; 7 Voskerician, G.; Shive, M.S.; Shawgo, R.S.; Recum, H.V.; Anderson, J.M.; Cima, M.J.; Langer, R. (C17) 2003; 24 Mukerjee, E.; Collins, S.; Isseroff, R.; Smith, R. (C5) 2004; 114 Chaudhri, B.P.; Ceyssens, F.; De Moor, P.; Van Hoof, C.; Puers, R. (C14) 2010; 20 Luttge, R.; Berenschot, E.J.; de Boer, M.J.; Altpeter, D.M.; Vrouwe, E.X.; van den Berg, A.; Elwenspoek, M. (C19) 2007; 16 Zahn, J.; Talbot, N.; Liepmann, D.; Pisano, A. (C9) 2000; 2 Davis, S.P.; Martanto, W.; Allen, M.G.; Prausnitz, M.R. (C15) 2005; 52 Tsuchiya, K.; Nakanishi, N.; Uetsuji, Y.; Nakamachi, E. (C12) 2005; 7 Hamilton, J.G. (C2) 1995; 41 Tsuchiya, K.; Nakanishi, N.; Nakamachi, E. (C10) 2005; 5651 Prausnitz, M.R. (C3) 2001; 3 Li, C.G.; Lee, C.Y.; Lee, K.; Jung, H. (C6) 2013; 15 1995; 41 2010; 20 2013; 15 2004; 114 2011 2004; 14 2006; 16 2004; 7 2003; 24 2002; 2 2005; 52 2005; 4 2005; 7 2008; 8 2001; 3 2000; 2 2014 2005; 5651 2009; 15 1997; 7 2007; 16 e_1_2_7_5_2 e_1_2_7_4_2 Kuo S.C. (e_1_2_7_8_2) 2004; 7 e_1_2_7_2_2 e_1_2_7_9_2 e_1_2_7_7_2 e_1_2_7_6_2 e_1_2_7_19_2 e_1_2_7_18_2 Hamilton J.G. (e_1_2_7_3_2) 1995; 41 e_1_2_7_17_2 Mitra S.K. (e_1_2_7_22_2) 2011 e_1_2_7_16_2 e_1_2_7_15_2 e_1_2_7_14_2 e_1_2_7_13_2 e_1_2_7_12_2 e_1_2_7_23_2 e_1_2_7_10_2 e_1_2_7_21_2 e_1_2_7_20_2 Tsuchiya K. (e_1_2_7_11_2) 2005; 5651 |
| References_xml | – volume: 2 start-page: 295 year: 2000 end-page: 303 ident: C9 article-title: Microfabricated polysilicon microneedles for minimally invasive biomedical devices publication-title: Biomedical Microdevices contributor: fullname: Zahn, J.; Talbot, N.; Liepmann, D.; Pisano, A. – volume: 7 start-page: 347 issue: 4 year: 2005 end-page: 353 ident: C12 article-title: Development of blood extraction system for health monitoring system publication-title: Biomed. Microdevices contributor: fullname: Tsuchiya, K.; Nakanishi, N.; Uetsuji, Y.; Nakamachi, E. – volume: 7 start-page: 121 issue: 3 year: 1997 ident: C16 article-title: SU-8: a low-cost negative resist for MEMS publication-title: J. Micromech. Microeng. contributor: fullname: Lorenz, H.; Despont, M.; Fahrni, N.; LaBianca, N.; Renaud, P.; Vettiger, P. – volume: 16 start-page: 872 issue: 4 year: 2007 end-page: 884 ident: C19 article-title: Integrated lithographic molding for microneedle-based devices publication-title: J. Microelectromech. Syst. contributor: fullname: Luttge, R.; Berenschot, E.J.; de Boer, M.J.; Altpeter, D.M.; Vrouwe, E.X.; van den Berg, A.; Elwenspoek, M. – volume: 16 start-page: 958 issue: 5 year: 2006 ident: C11 article-title: Microfabricated microneedle with porous tip for drug delivery publication-title: J. Micromech. Microeng. contributor: fullname: Ji, J.; Tay, F.E.; Miao, J.; Iliescu, C. – volume: 7 start-page: 95 year: 2004 end-page: 98 ident: C7 article-title: A novel polymer microneedle arrays and PDMS micromolding publication-title: Tamkang J. Sci. Eng. contributor: fullname: Kuo, S.C.; Chou, Y. – volume: 24 start-page: 1959 issue: 11 year: 2003 end-page: 1967 ident: C17 article-title: Biocompatibility and biofouling of MEMS drug delivery devices publication-title: Biomaterials contributor: fullname: Voskerician, G.; Shive, M.S.; Shawgo, R.S.; Recum, H.V.; Anderson, J.M.; Cima, M.J.; Langer, R. – volume: 15 start-page: 17 issue: 1 year: 2013 end-page: 25 ident: C6 article-title: An optimized hollow microneedle for minimally invasive blood extraction publication-title: Biomed. Microdevices contributor: fullname: Li, C.G.; Lee, C.Y.; Lee, K.; Jung, H. – volume: 14 start-page: 597 issue: 4 year: 2004 end-page: 603 ident: C8 article-title: A tapered hollow metallic microneedle array using backside exposure of SU-8 publication-title: J. Micromech. Microengineering contributor: fullname: Kim, K.; Park, D.S.; Lu, H.M.; Che, W.; Kim, K.; Lee, J.B.; Ahn, C.H. – volume: 114 start-page: 267 issue: 2 year: 2004 end-page: 275 ident: C5 article-title: Microneedle array for transdermal biological fluid extraction and in situ analysis publication-title: Sens. Actuators A, Phys. contributor: fullname: Mukerjee, E.; Collins, S.; Isseroff, R.; Smith, R. – volume: 8 start-page: 1830 issue: 11 year: 2008 end-page: 1836 ident: C18 article-title: Biocompatible SU-8-based microprobes for recording neural spike signals from regenerated peripheral nerve fibers publication-title: IEEE Sens. J. contributor: fullname: Cho, S.H.; Lu, H.M.; Cauller, L.; Romero-Ortega, M.I.; Lee, J.B.; Hughes, G.A. – volume: 15 start-page: 1073 issue: 7 year: 2009 end-page: 1082 ident: C4 article-title: Design and fabrication of MEMS-based microneedle arrays for medical applications publication-title: Microsyst. Technol. contributor: fullname: Zhang, P.; Dalton, C.; Jullien, G.A. – volume: 14 start-page: 597 issue: 4 year: 2004 ident: C13 article-title: A tapered hollow metallic microneedle array using backside exposure of SU-8 publication-title: J. Micromech. Microeng. contributor: fullname: Kim, K.; Park, D.S.; Lu, H.M.; Che, W.; Kim, K.; Lee, J.B.; Ahn, C.H. – volume: 20 start-page: 064006 issue: 6 year: 2010 ident: C14 article-title: A high aspect ratio SU-8 fabrication technique for hollow microneedles for transdermal drug delivery and blood extraction publication-title: J. Micromech. Microeng. contributor: fullname: Chaudhri, B.P.; Ceyssens, F.; De Moor, P.; Van Hoof, C.; Puers, R. – volume: 52 start-page: 909 issue: 5 year: 2005 end-page: 915 ident: C15 article-title: Hollow metal microneedles for insulin delivery to diabetic rats publication-title: IEEE Trans. Biomed. Eng. contributor: fullname: Davis, S.P.; Martanto, W.; Allen, M.G.; Prausnitz, M.R. – volume: 2 start-page: 289 issue: 1 year: 2002 end-page: 313 ident: C1 article-title: Microfabricated microneedles for gene and drug delivery publication-title: Ann. Rev. Biomed. Eng. contributor: fullname: McAllister, D.V.; Allen, M.G.; Prausnitz, M.R. – volume: 4 start-page: 043008 issue: 4 year: 2005 end-page: 043008 ident: C22 article-title: Low-stress ultra-thick SU-8 UV photolithography process for MEMS publication-title: J. Micro/Nanolithography MEMS MOEMS contributor: fullname: Li, B.; Liu, M.; Chen, Q. – volume: 3 start-page: 233 issue: 2 year: 2001 end-page: 236 ident: C3 article-title: Analysis: overcoming skin's barrier: the search for effective and user-friendly drug delivery publication-title: Diabetes Technol. Ther. contributor: fullname: Prausnitz, M.R. – volume: 5651 start-page: 379 year: 2005 end-page: 388 ident: C10 article-title: Development of blood extraction system designed by female mosquito's blood sampling mechanism for bio-MEMS publication-title: Biomed. Appl. Micro and Nanoeng. contributor: fullname: Tsuchiya, K.; Nakanishi, N.; Nakamachi, E. – volume: 41 start-page: 169 issue: 2 year: 1995 end-page: 175 ident: C2 article-title: Needle phobia: a neglected diagnosis publication-title: J. Fam. Pract. contributor: fullname: Hamilton, J.G. – volume: 24 start-page: 1959 issue: 11 year: 2003 end-page: 1967 article-title: Biocompatibility and biofouling of MEMS drug delivery devices publication-title: Biomaterials – year: 2011 – volume: 15 start-page: 1073 issue: 7 year: 2009 end-page: 1082 article-title: Design and fabrication of MEMS‐based microneedle arrays for medical applications publication-title: Microsyst. Technol. – volume: 7 start-page: 347 issue: 4 year: 2005 end-page: 353 article-title: Development of blood extraction system for health monitoring system publication-title: Biomed. Microdevices – start-page: 430 year: 2014 end-page: 435 article-title: A novel design of hollow microneedle for blood extraction – volume: 20 start-page: 064006 issue: 6 year: 2010 article-title: A high aspect ratio SU‐8 fabrication technique for hollow microneedles for transdermal drug delivery and blood extraction publication-title: J. Micromech. Microeng. – volume: 16 start-page: 872 issue: 4 year: 2007 end-page: 884 article-title: Integrated lithographic molding for microneedle‐based devices publication-title: J. Microelectromech. Syst. – volume: 7 start-page: 95 year: 2004 end-page: 98 article-title: A novel polymer microneedle arrays and PDMS micromolding publication-title: Tamkang J. Sci. Eng. – volume: 5651 start-page: 379 year: 2005 end-page: 388 article-title: Development of blood extraction system designed by female mosquito's blood sampling mechanism for bio‐MEMS publication-title: Biomed. Appl. Micro and Nanoeng. – volume: 4 start-page: 043008 issue: 4 year: 2005 end-page: 043008 article-title: Low‐stress ultra‐thick SU‐8 UV photolithography process for MEMS publication-title: J. Micro/Nanolithography MEMS MOEMS – volume: 41 start-page: 169 issue: 2 year: 1995 end-page: 175 article-title: Needle phobia: a neglected diagnosis publication-title: J. Fam. Pract. – volume: 2 start-page: 289 issue: 1 year: 2002 end-page: 313 article-title: Microfabricated microneedles for gene and drug delivery publication-title: Ann. Rev. Biomed. Eng. – volume: 7 start-page: 121 issue: 3 year: 1997 article-title: SU‐8: a low‐cost negative resist for MEMS publication-title: J. Micromech. Microeng. – volume: 2 start-page: 295 year: 2000 end-page: 303 article-title: Microfabricated polysilicon microneedles for minimally invasive biomedical devices publication-title: Biomedical Microdevices – volume: 16 start-page: 958 issue: 5 year: 2006 article-title: Microfabricated microneedle with porous tip for drug delivery publication-title: J. Micromech. Microeng. – volume: 3 start-page: 233 issue: 2 year: 2001 end-page: 236 article-title: Analysis: overcoming skin's barrier: the search for effective and user‐friendly drug delivery publication-title: Diabetes Technol. Ther. – volume: 8 start-page: 1830 issue: 11 year: 2008 end-page: 1836 article-title: Biocompatible SU‐8‐based microprobes for recording neural spike signals from regenerated peripheral nerve fibers publication-title: IEEE Sens. J. – volume: 14 start-page: 597 issue: 4 year: 2004 article-title: A tapered hollow metallic microneedle array using backside exposure of SU‐8 publication-title: J. Micromech. Microeng. – volume: 15 start-page: 17 issue: 1 year: 2013 end-page: 25 article-title: An optimized hollow microneedle for minimally invasive blood extraction publication-title: Biomed. Microdevices – volume: 52 start-page: 909 issue: 5 year: 2005 end-page: 915 article-title: Hollow metal microneedles for insulin delivery to diabetic rats publication-title: IEEE Trans. Biomed. Eng. – volume: 114 start-page: 267 issue: 2 year: 2004 end-page: 275 article-title: Microneedle array for transdermal biological fluid extraction and in situ analysis publication-title: Sens. Actuators A, Phys. – volume: 14 start-page: 597 issue: 4 year: 2004 end-page: 603 article-title: A tapered hollow metallic microneedle array using backside exposure of SU‐8 publication-title: J. Micromech. Microengineering – ident: e_1_2_7_5_2 doi: 10.1007/s00542‐009‐0883‐5 – ident: e_1_2_7_4_2 doi: 10.1089/152091501300209606 – ident: e_1_2_7_2_2 doi: 10.1146/annurev.bioeng.2.1.289 – ident: e_1_2_7_6_2 doi: 10.1016/j.sna.2003.11.008 – ident: e_1_2_7_17_2 doi: 10.1088/0960‐1317/7/3/010 – volume: 41 start-page: 169 issue: 2 year: 1995 ident: e_1_2_7_3_2 article-title: Needle phobia: a neglected diagnosis publication-title: J. Fam. Pract. contributor: fullname: Hamilton J.G. – volume: 7 start-page: 95 year: 2004 ident: e_1_2_7_8_2 article-title: A novel polymer microneedle arrays and PDMS micromolding publication-title: Tamkang J. Sci. Eng. contributor: fullname: Kuo S.C. – ident: e_1_2_7_10_2 doi: 10.1023/A:1009907306184 – ident: e_1_2_7_13_2 doi: 10.1007/s10544‐005‐6077‐8 – ident: e_1_2_7_14_2 doi: 10.1088/0960‐1317/14/4/021 – ident: e_1_2_7_20_2 doi: 10.1109/JMEMS.2007.899339 – ident: e_1_2_7_18_2 doi: 10.1016/S0142‐9612(02)00565‐3 – ident: e_1_2_7_7_2 doi: 10.1007/s10544‐012‐9683‐2 – volume-title: Microfluidics and nanofluidics handbook: fabrication, implementation, and applications year: 2011 ident: e_1_2_7_22_2 doi: 10.1201/b11377 contributor: fullname: Mitra S.K. – ident: e_1_2_7_9_2 doi: 10.1088/0960‐1317/14/4/021 – ident: e_1_2_7_12_2 doi: 10.1088/0960‐1317/16/5/012 – ident: e_1_2_7_19_2 doi: 10.1109/JSEN.2008.2006261 – ident: e_1_2_7_21_2 doi: 10.1109/NEMS.2014.6908843 – ident: e_1_2_7_16_2 doi: 10.1109/TBME.2005.845240 – ident: e_1_2_7_23_2 doi: 10.1117/1.2117108 – volume: 5651 start-page: 379 year: 2005 ident: e_1_2_7_11_2 article-title: Development of blood extraction system designed by female mosquito's blood sampling mechanism for bio‐MEMS publication-title: Biomed. Appl. Micro and Nanoeng. contributor: fullname: Tsuchiya K. – ident: e_1_2_7_15_2 doi: 10.1088/0960‐1317/20/6/064006 |
| SSID | ssj0047279 |
| Score | 2.0362833 |
| Snippet | A highly applicable theoretical model and a simple, inexpensive mould-based method is introduced to design and fabricate the pyramid-shaped SU-8 microneedle.... A highly applicable theoretical model and a simple, inexpensive mould‐based method is introduced to design and fabricate the pyramid‐shaped SU‐8 microneedle.... |
| SourceID | proquest crossref wiley iet |
| SourceType | Aggregation Database Publisher Enrichment Source |
| StartPage | 644 |
| SubjectTerms | biomedical measurement Blood blood circulation blood vessels Fingers finite element analysis finite element study force measurement fracture fracture force measurement Fracture mechanics geometry optimisation haemodynamics haemorheology Human human fingers inexpensive mould‐based method Mathematical models Nanostructure needles nurse‐home patients optimal design Optimization Patients point‐of‐care sites polymers practical measurement practical verification pyramid‐shaped SU‐8 microneedle Raynaud phenomenon safely puncture human skin size 1470 mum size 1515 mum skin skin penetrability Special Section of Expanded Papers from NEMS 2014 Vulnerability whole blood extraction |
| Title | Optimal design of polymer-based microneedle for improved collection of whole blood from human fingers |
| URI | http://digital-library.theiet.org/content/journals/10.1049/mnl.2014.0242 https://onlinelibrary.wiley.com/doi/abs/10.1049%2Fmnl.2014.0242 https://www.proquest.com/docview/1640675905/abstract/ https://search.proquest.com/docview/1660073527 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR3LTsMwzIJxgQPiKQpjCghxK3RNOprjhjYhBGNCQ-JWpWmCJu0l2IS48Ql8I1-CnXawHUDi2sRpYsfxI44NcKIjrQ3XwucCLR1hVeRLLRSlEA1qqTbKZOTvuG3Xrh7E9WP0WNQ5pbcweX6Ib4cbcYY7r4nBVZpXIUGlFok4GNLNQVWckZRZhhVUbWLa1qHozI5igcJZuheREcUwCl4k2cQBzhfAF4TScs9MFvTNea3ViZ3WBqwX-iKr5wTehCUz3IK1uSyC2_B0h2w_wE6Zi8ZgI8vGo_7bwDx_vn-QlMrYgMLuECDrG4ZaKus5VwI20DZwwVgO7JWK5TIXy87o3QlzFfyYda6_lx3otprdyyu_qJ_gazS6Qp-nios0VMhjVGjMhgKNA1xzJGsiMEYiLVSVG2lUVaQWLSceC2sCbbPUyljzXSgNcW57wLiNAx1wsj0ioblGQhrCm1X4PZbGg9MZ_pJxniUjcbfbQiaI6IQQnRCAB8eI3aTgk5ffOlUWOt22b34ak3FmPSjPqDM3FC4KrR8ZRB4cfTcjs9ANiBqa0ZT6uHT8UXjhwbmj6t_TxV_Xw0aLfOfh_r8hDmCVvuehf2UoTZ6n5hBVmElacdu0AiuNZrtz_wVFsupa |
| link.rule.ids | 315,786,790,11589,27957,27958,33779,33780,46087,46511,50849,50958 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR3LTsMwzOJxAA6IpyjPgBC3Qte4YzkCYhqwDQ5D4lalaYKQ2EMwhLjxCXwjX4KdbrAdQOLa2Gljx_Ujjg2wbxJjrDQYSiRPB51OQmVQcwnRqJwZq23O8Y5Gs1y7xcu75G7kFn9RH-I74MaS4f_XLOAckC4cTuQime0OHx2U8JDVzCRMc1dvFs0Yb4b_YiTtrPyVyISTGFEOqmzSBEdj6GNaafLB9scMzlGz1eud6gLMDwxGcVJweBEmbGcJ5kbKCC7D_TXJfZuAcp-OIbpO9LqPb2379Pn-wWoqF23OuyOE_NEKMlPFg48l0ADvA5-N5dFeuVuu8Mnsgi-eCN_CTzgf-3tegVb1vHVWCwcNFEJDXlccykxLzGJNQsadxlyM5B3QmhNVxshaRczQJWmV1SXMHLlOsoLORsblmVMVI1dhqkPftgZCukpkIsnOR4JGGuKkZbo5Tc8rygZwMKRf2ivKZKT-eBtVSoROmdApIwSwR9RNB4Ly_BvQ9hhQo1n_GUx7uQtgc8idkaloUeT-qCgJYPd7mKSFj0B0x3ZfGMbX40_i4wCOPFf__lx69Ul8WuXgebz-b4wdmKm1GvW0ftG82oBZhinyADdhqv_0YrfInuln237LfgF3Wewh |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR3LThsxcESIhNpDBZSqW16mqrhts1nPhvgYWqIUkpRDgqJeVl6vXSGRhyCo6q2f0G_slzDj3UByAKnX9dhrz3g8D49nAD6ZxBgrDYYSydJBp5NQGdScQjRqZMZqm7O_o9dvdIZ4PkpGZZ1TfgtT5Id4dLgxZ_jzmhl8lrvC3kTOkTme8M1BHT-zlKlAlTQNpG1dbV0NfwwXhzGSeFb-TWTCUYwoyzSbNERtZYAVsVS5tvMVjXNZb_WCp70Jb0qNUbQKEm_Bmp1sw-ulPIJv4ed3YvwxAeU-HkNMnZhNb36P7e2_P39ZTuVizIF31CG_sYL0VHHtnQnUwBvBh2P5br-4XK7w0eyCX54IX8NPOO_8u9uBQfts8KUTlhUUQkNmVxzKTEvMYk1cxqXGXIxkHtCaE9XAyFpF1NB1aZXVdcwc2U6yic5GxuWZU00j38H6hOb2HoR0zchEkq2PBI00RErLeHOavjeVDeB4gb90VuTJSP39NqqUEJ0yolPuEMBHwm5acsrdc0AHK0C9fvepMaV9EMDegjpLQ9GiyP5RURLA0WMzsQvfgeiJnd4zjE_In8QnAdQ8VV-eLv26FZ-22Xsef_jvHoewcfm1nXa_9S924RWDFHGAe7A-v723-6TPzLODcs8-ALf-7SI |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Optimal+design+of+polymer-based+microneedle+for+improved+collection+of+whole+blood+from+human+fingers&rft.jtitle=Micro+%26+nano+letters&rft.au=Thanh%2C+Hoa+Le&rft.au=The%2C+Hai+Le&rft.au=Nguyen%2C+Vy&rft.au=Tran-Minh%2C+Nhut&rft.date=2014-10-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.eissn=1750-0443&rft.volume=9&rft.issue=10&rft.spage=644&rft_id=info:doi/10.1049%2Fmnl.2014.0242&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=3538298401 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1750-0443&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1750-0443&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1750-0443&client=summon |