Mathematical Biology Models of Parkinson's Disease

• Published in: CPT: pharmacometrics and systems pharmacology Vol. 8; no. 2; pp. 77 - 86
• Main Authors: Bakshi, Suruchi, Chelliah, Vijayalakshmi, Chen, Chao, Graaf, Piet H.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2019; John Wiley and Sons Inc
• Subjects: Alzheimer's disease; Brain; Clinical trials; Dopamine; Feedback; Metabolism; Nitrogen; NMR; Nuclear magnetic resonance; Ordinary differential equations; Oxidative stress; Parkinson's disease; Pathogenesis; Polymerization; Review; Reviews; System theory

Parkinsons disease (PD) is a progressive neurodegenerative disease with substantial and growing socio‐economic burden. In this multifactorial disease, aging, environmental, and genetic factors contribute to neurodegeneration and dopamine (DA) deficiency in the brain. Treatments aimed at DA restorati...