Sex‐specific clinical outcomes after cardiac resynchronization therapy in left bundle branch block‐associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy

• Published in: Annals of noninvasive electrocardiology Vol. 24; no. 4; pp. e12641 - n/a
• Main Authors: Wang, Norman C., Mezu‐Chukwu, Ure, Adelstein, Evan C., Althouse, Andrew D., Sharbaugh, Michael S., Jain, Sandeep K., Shalaby, Alaa A., Voigt, Andrew H., Saba, Samir
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.07.2019; John Wiley and Sons Inc
• Subjects: Bundle-Branch Block - complications; Bundle-Branch Block - therapy; cardiac resynchronization therapy; Cardiac Resynchronization Therapy - methods; Cardiomyopathies - etiology; Cardiomyopathies - therapy; Cardiomyopathy; Clinical outcomes; Cohort Studies; Confidence intervals; Congestive heart failure; Defibrillators; Defibrillators, Implantable - statistics & numerical data; Electric Countershock - statistics & numerical data; Female; Gender aspects; Gender differences; Health care facilities; Health risk assessment; Heart; Heart transplantation; Heart Transplantation - statistics & numerical data; Humans; Implantation; Kaplan-Meier Estimate; left bundle branch block; Male; Men; Middle Aged; Mortality; nonischemic cardiomyopathy; Original; Regression analysis; Retrospective Studies; Risk; Sex; Sex differences; Sex Factors; sex‐specific; Statistical analysis; Therapy; Transplantation; Treatment Outcome; Ventricle; Women; clinical outcomes; sex-specific; left bundle branch block; nonischemic cardiomyopathy; cardiac resynchronization therapy
• ISSN: 1082-720X; 1542-474X; 1542-474X
• DOI: 10.1111/anec.12641

Background Sex differences in clinical outcomes for left bundle branch block (LBBB)‐associated idiopathic nonischemic cardiomyopathy (NICM) after cardiac resynchronization therapy (CRT) are not well described. Methods A retrospective cohort study at an academic medical center included subjects with LBBB‐associated idiopathic NICM who received CRT. Cox regression analyses estimated the hazard ratios (HRs) between sex and clinical outcomes. Results In 123 total subjects (mean age 62 years, mean initial left ventricular ejection fraction 22.8%, 76% New York Heart Association class III, and 98% CRT‐defibrillators), 55 (45%) were men and 68 (55%) were women. The median follow‐up time after CRT was 72.4 months. Similar risk for adverse clinical events (heart failure hospitalization, appropriate implantable cardioverter‐defibrillator shock, appropriate antitachycardia pacing therapy, ventricular assist device implantation, heart transplantation, and death) was observed between men and women (HR, 1.20; 95% confidence interval [CI] 0.57–2.51; p = 0.63). This persisted in multivariable analyses. Men and women had similar risk for all‐cause mortality in univariable analysis, but men had higher risk in the final multivariable model that adjusted for age at diagnosis, QRS duration, and left ventricular end‐diastolic dimension index (HR, 4.55; 95% CI, 1.26–16.39; p = 0.02). The estimated 5‐year mortality was 9.5% for men and 6.9% for women. Conclusions In LBBB‐associated idiopathic NICM, men have higher risk for all‐cause mortality after CRT when compared to women.