Inflammatory biomarkers of low back pain and disc degeneration: a review

• Published in: Annals of the New York Academy of Sciences Vol. 1410; no. 1; pp. 68 - 84
• Main Authors: Khan, Aysha N., Jacobsen, Hayley E., Khan, Jansher, Filippi, Christopher G., Levine, Mitchell, Lehman, Ronald A., Riew, K. Daniel, Lenke, Lawrence G., Chahine, Nadeen O.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2017
• Subjects: Arthritis; Back pain; Biomarkers; Biomarkers - blood; Cytokines - blood; Degeneration; Diagnostic systems; Humans; Inflammation; Inflammation Mediators - blood; intervertebral disc degeneration; Intervertebral Disc Degeneration - blood; Intervertebral Disc Degeneration - diagnosis; Intervertebral Disc Degeneration - therapy; Intervertebral discs; Low back pain; Low Back Pain - blood; Low Back Pain - diagnosis; Low Back Pain - therapy; Outcome Assessment (Health Care) - methods; Pain; Pathogenesis; Population studies; Sensitivity and Specificity; Spinal stenosis; Spine; Surgical instruments; Symptomology; intervertebral disc degeneration; spine; back pain; inflammation; biomarkers

Biomarkers are biological characteristics that can be used to indicate health or disease. This paper reviews studies on biomarkers of low back pain (LBP) in human subjects. LBP is the leading cause of disability, caused by various spine‐related disorders, including intervertebral disc degeneration,...