ST2 blockade mitigates peritoneal fibrosis induced by TGF‐β and high glucose

• Published in: Journal of cellular and molecular medicine Vol. 23; no. 10; pp. 6872 - 6884
• Main Authors: Kim, Yong Chul, Kim, Kyu Hong, Lee, Sunhwa, Jo, Ji‐won, Park, Jae Yoon, Park, Mi‐seon, Tsogbadrakh, Bodokhsuren, Lee, Jung Pyo, Lee, Jae Wook, Kim, Dong Ki, Oh, Kook‐Hwan, Jang, In‐Jin, Kim, Yon Su, Cha, Ran‐hui, Yang, Seung Hee
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2019; John Wiley and Sons Inc
• Subjects: Animal models; Animals; Biomarkers; Cell culture; Cells, Cultured; Chlorhexidine; Disease Models, Animal; Effluents; Epithelial-Mesenchymal Transition - drug effects; Epithelium - pathology; Female; Fibroblasts; Fibronectin; Fibrosis; Gene expression; Glucose - toxicity; Growth factors; Heart attacks; Hemodialysis; Humans; Inflammation; Interleukin-1 Receptor-Like 1 Protein - antagonists & inhibitors; Interleukin-1 Receptor-Like 1 Protein - metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Original; Peritoneal Dialysis; peritoneal fibrosis; Peritoneal Fibrosis - pathology; Peritoneum; Peritoneum - pathology; Preservation; Proportional Hazards Models; Snail protein; soluble ST2; ST2 blockade; Survival Analysis; Transforming Growth Factor beta - toxicity; Transforming growth factor-b; Tumorigenicity; β-Galactosidase; peritoneal fibrosis; ST2 blockade; peritoneal dialysis; soluble ST2

Peritoneal fibrosis (PF) is an intractable complication of peritoneal dialysis (PD) that leads to peritoneal membrane failure. This study investigated the role of suppression of tumorigenicity (ST)2 in PF using patient samples along with mouse and cell‐based models. Baseline dialysate soluble (s)ST2...