Phase I clinical trial of HC‐1119 soft capsule in Chinese healthy adult male subjects: Pharmacokinetics and safety of single‐dose proportionality and effects of food - Ma, Haiping; Xu, Weidong; Ni, Jin; Zhao, Naping; Tang, Shouyan; Li, Song; Cai, Tingting; Xiu, Jianping; Kang, Xin; Gao, Shen; Zhang, Li; Zhou, Tie (The Prostate, 2022)
Keywords: Administration, Oral; Adult; Androgen receptors; Androgens; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacokinetics; Apoptosis; Benzamides - administration & dosage; Benzamides - adverse effects; Benzamides - pharmacokinetics; Biomarkers, Pharmacological - analysis; Capsules; Cell proliferation; Cell Proliferation - drug effects; China; Chinese healthy adult male; deuterated enzalutamide; Dose-Response Relationship, Drug; dose‐proportionality; Drug dosages; Drug Stability; Fasting; food effect; Food-Drug Interactions; Half-Life; Healthy Volunteers; High fat diet; Humans; Male; Metabolites; Nitriles - administration & dosage; Nitriles - adverse effects; Nitriles - pharmacokinetics; Original; Pharmacokinetics; Phenylthiohydantoin - administration & dosage; Phenylthiohydantoin - adverse effects; Phenylthiohydantoin - pharmacokinetics; Prostate cancer; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Receptors, Androgen - metabolism; Safety; Signal transduction; Signal Transduction - drug effects; Statistical analysis; China; Chinese healthy adult male; dose-proportionality; pharmacokinetics; deuterated enzalutamide; food effect