Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender‐specific changes in the microRNA expression profiling in ME/CFS

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/C...

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Published inJournal of cellular and molecular medicine Vol. 24; no. 10; pp. 5865 - 5877
Main Authors Cheema, Amanpreet K., Sarria, Leonor, Bekheit, Mina, Collado, Fanny, Almenar‐Pérez, Eloy, Martín‐Martínez, Eva, Alegre, Jose, Castro‐Marrero, Jesus, Fletcher, Mary A., Klimas, Nancy G., Oltra, Elisa, Nathanson, Lubov
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.05.2020
John Wiley and Sons Inc
Subjects
Age
Biomarkers
Blood
Body mass index
Case-Control Studies
Chronic fatigue syndrome
Encephalomyelitis
Exercise
Fasting
Fatigue
Fatigue Syndrome, Chronic - genetics
Female
Females
Gender
Gene Expression Profiling
Gene Expression Regulation
Humans
immune function
Immune response
inflammation
Leukocytes (mononuclear)
Male
Males
Mental health
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
miRNA
myalgic encephalomyelitis/chronic fatigue syndrome
Nutritional status
Original
Pain
peripheral blood mononuclear cell
Peripheral blood mononuclear cells
Sex Characteristics
Software
Time Factors
microRNAs
gender
inflammation
immune function
exercise
myalgic encephalomyelitis/chronic fatigue syndrome
peripheral blood mononuclear cell
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Summary:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/CFS subjects under an exercise challenge. The findings highlight the immune response and inflammation links to differential miRNA expression in ME/CFS. The present study is particularly important in being the first to uncover the differences that exist in miRNA expression patterns in males and females with ME/CFS in response to exercise. This provides new evidence for the understanding of differential miRNA expression patterns and post‐exertional malaise in ME/CFS. We also report miRNA expression pattern differences associating with the nutritional status in individuals with ME/CFS, highlighting the effect of subjects' metabolic state on molecular changes to be considered in clinical research within the NINDS/CDC ME/CFS Common Data Elements. The identification of gender‐based miRNAs importantly provides new insights into gender‐specific ME/CFS susceptibility and demands exploration of sex‐suited ME/CFS therapeutics.
Bibliography:Funding information
The sponsors had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by either by the Department of Defense or National Institute of Health.
This study was supported by NIH awards 1R15NS087604‐01A1, 1R21AI124187‐01 and Presidential Faculty Research and Development Grant from Nova Southeastern University (all awarded to LN). We are grateful to all the participants who took part in the studies. The study used PBMC samples collected under CDMRP award W81XWH‐09‐2‐0071 (PI: NK), NIH awards 5R01NS090200‐02 (PI: MAF) and 5R01AR057853‐04 (PI: NK), UCV‐2019‐270‐001 (PI: EO) and Catalonia Association for Fibromyalgia, Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Environmental Sensitivities/Multiple Chemical Sensitivity (ACAF
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This study was supported by NIH awards 1R15NS087604‐01A1, 1R21AI124187‐01 and Presidential Faculty Research and Development Grant from Nova Southeastern University (all awarded to LN). We are grateful to all the participants who took part in the studies. The study used PBMC samples collected under CDMRP award W81XWH‐09‐2‐0071 (PI: NK), NIH awards 5R01NS090200‐02 (PI: MAF) and 5R01AR057853‐04 (PI: NK), UCV‐2019‐270‐001 (PI: EO) and Catalonia Association for Fibromyalgia, Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Environmental Sensitivities/Multiple Chemical Sensitivity (ACAF, http://www.fibromialgia.cat). The sponsors had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by either by the Department of Defense or National Institute of Health.
ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.15260