Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood

• Published in: Alcoholism, clinical and experimental research Vol. 46; no. 5; pp. 759 - 769
• Main Authors: Dannenhoffer, Carol A., Gómez‐A, Alexander, Macht, Victoria A., Jawad, Rayyanoor, Sutherland, Elizabeth Blake, Vetreno, Ryan P., Crews, Fulton T., Boettiger, Charlotte A., Robinson, Donita L.
• Format: Journal Article
• Language: English
• Published: England 01.05.2022
• Subjects: Adolescent; adolescent intermittent EtOH exposure; Adult; Animals; choline acetyltransferase; Ethanol - metabolism; Extracellular Matrix - metabolism; Humans; Interneurons - metabolism; Male; parvalbumin; Parvalbumins - metabolism; perineuronal nets; prefrontal cortex; Prefrontal Cortex - metabolism; Rats; choline acetyltransferase; parvalbumin; prefrontal cortex; adolescent intermittent EtOH exposure; perineuronal nets

Background Binge alcohol exposure during adolescence results in long‐lasting alterations in the brain and behavior. For example, adolescent intermittent ethanol (AIE) exposure in rodents results in long‐term loss of functional connectivity among prefrontal cortex (PFC) and striatal regions as well a...