Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease

• Published in: The Laryngoscope Vol. 114; no. 12; p. 2129
• Main Authors: Johnston, Nikki, Knight, John, Dettmar, Peter W, Lively, Mark O, Koufman, Jamie
• Format: Journal Article
• Language: English
• Published: United States 01.12.2004
• Subjects: Biomarkers - analysis; Biopsy, Needle; Blotting, Western; Carbonic Anhydrase III - analysis; Carbonic Anhydrase III - metabolism; Case-Control Studies; Chi-Square Distribution; Electrophoresis, Polyacrylamide Gel; Esophagitis, Peptic - enzymology; Esophagitis, Peptic - pathology; Female; Gastric Acidity Determination; Gastroesophageal Reflux - diagnosis; Gastroesophageal Reflux - enzymology; Humans; Immunohistochemistry; Isoenzymes - analysis; Isoenzymes - metabolism; Laryngeal Mucosa - enzymology; Laryngeal Mucosa - pathology; Male; Pepsin A - analysis; Pepsin A - metabolism; Probability; Prognosis; Prospective Studies; Risk Assessment; Sampling Studies; Sensitivity and Specificity; Severity of Illness Index; Tissue Culture Techniques

The objective was to investigate the potential use of pepsin and carbonic anhydrase isoenzyme III (CA-III) as diagnostic markers for laryngopharyngeal reflux disease. Prospective cell biological investigation was conducted of laryngeal biopsy specimens taken from 9 patients with laryngopharyngeal re...