MicroRNA‐302c‐3p inhibits endothelial cell pyroptosis via directly targeting NOD‐, LRR‐ and pyrin domain‐containing protein 3 in atherosclerosis

• Published in: Journal of cellular and molecular medicine Vol. 25; no. 9; pp. 4373 - 4386
• Main Authors: Bai, Baochen, Yang, Yanyan, Ji, Shengxiang, Wang, Shizhong, Peng, Xingang, Tian, Chao, Sun, Rui‐Cong, Yu, Tao, Chu, Xian‐ming
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2021; John Wiley and Sons Inc
• Subjects: Antibodies; Arteriosclerosis; Atherosclerosis; Bioinformatics; Cardiovascular disease; Coronary vessels; endothelial cell; Endothelial cells; Gene expression; Inflammasomes; Inflammation; Laboratory animals; MicroRNAs; miRNA; miR‐302c‐3p; NLRP3; Original; Plaques; Proteins; Pyrin protein; Pyroptosis; Reagents; Beijing China; United States > US; China; atherosclerosis; miR-302c-3p; pyroptosis; NLRP3; endothelial cell

Inflammation and endothelial dysfunction are important participants and drivers in atherosclerosis. NOD‐, LRR‐ and pyrin domain‐containing protein 3 (NLRP3) inflammasome activation and the resulting pyroptosis are involved in the initiation and vicious circle of chronic inflammation, thus playing an...