Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection

• Published in: The Journal of biological chemistry Vol. 294; no. 10; pp. 3397 - 3405
• Main Authors: Zhang, Yanzhao, Tada, Takuya, Ozono, Seiya, Yao, Weitong, Tanaka, Michiko, Yamaoka, Shoji, Kishigami, Satoshi, Fujita, Hideaki, Tokunaga, Kenzo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.03.2019; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; antiviral factor; Carrier Proteins - chemistry; Carrier Proteins - metabolism; Cell Line; glycoprotein; HIV; HIV-1; HIV-1 - physiology; host–pathogen interaction; Humans; macrophage; MARCH family; membrane protein; Membrane Proteins - chemistry; Membrane Proteins - metabolism; membrane-associated RING-CH; Microbiology; Ubiquitin-Protein Ligases - chemistry; Ubiquitin-Protein Ligases - metabolism; HIV-1; antiviral factor; MARCH family; HIV; host–pathogen interaction; membrane protein; macrophage; glycoprotein; membrane-associated RING-CH

Membrane-associated RING-CH 8 (MARCH8) is one of 11 members of the MARCH family of RING finger E3 ubiquitin ligases and down-regulates several membrane proteins (e.g. major histocompatibility complex II [MHC-II], CD86, and transferrin receptor). We recently reported that MARCH8 also targets HIV-1 en...