Maternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner

• Published in: International journal of molecular sciences Vol. 25; no. 8; p. 4136
• Main Authors: Schavinski, Aline Z, Reis, Natany G, Morgan, Henrique J N, Assis, Ana Paula, Moro, Matheus L, Valentim, Rafael R, Seni-Silva, Ana Carolina, Ramos, Ester S, Kettelhut, Isis C, Navegantes, Luiz C C
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Alfacalcidol; Animals; Calcifediol; Cell cycle; Female; Females; fetal programming; Fetus; Glucose; Growth; Homeostasis; Insulin - blood; Insulin - metabolism; Insulin resistance; Insulin Secretion; Insulin-Secreting Cells - metabolism; Male; Males; Metabolism; Metabolites; Pancreas; Pancreatic beta cells; Physiological aspects; Pregnancy; Prenatal Exposure Delayed Effects - etiology; Prenatal Exposure Delayed Effects - metabolism; Rats; Rats, Wistar; Scientific equipment and supplies industry; Sex Factors; Sexes; sexual dimorphism; Type 2 diabetes; Vitamin D; Vitamin D Deficiency - metabolism; Vitamin deficiency; Weaning; β cell function; Brazil; United States; fetal programming; vitamin D; β cell function; sexual dimorphism

Recent studies have shown that maternal vitamin D deficiency (VDD) causes long-term metabolic changes in offspring. However, little is known about the impact of maternal VDD on offspring endocrine pancreas development and insulin secretion in the adult life of male and female animals. Female rats (W...