Sublethal Sodium Hypochlorite Exposure: Impact on Resistance-Nodulation-Cell Division Efflux Pump Overexpression and Cross-Resistance to Imipenem

• Published in: Antibiotics (Basel) Vol. 13; no. 9; p. 828
• Main Authors: Nam, Ji-Hyun, Yoo, Jung Sik
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024; MDPI
• Subjects: Antibiotic resistance; Antibiotics; Antimicrobial agents; Antiseptics; Bacteria; Biofilms; Cell division; Chlorine; COVID-19; Cross-resistance; Disinfectants; Disinfection & disinfectants; Dosage and administration; Drug resistance; Drug resistance in microorganisms; Efflux; Exposure; Genes; Gram-negative bacteria; Health aspects; Health care facilities; Imipenem; imipenem antibiotics; Impact resistance; Minimum inhibitory concentration; NaOCl disinfectant; Nodulation; Oxidation; Pathogens; resistance-nodulation-cell division (RND) efflux pump; Risk factors; Sodium; Sodium hypochlorite; Statistical analysis; Transcriptomes; Transcriptomics; South Korea; resistance-nodulation-cell division (RND) efflux pump; cross-resistance; imipenem antibiotics; NaOCl disinfectant

Sodium hypochlorite (NaOCl) is widely used in public healthcare facilities; this exposure can result in the development of bacterial tolerance to disinfectants, which has known links to antibiotic cross-resistance. However, the mechanism through which cross-resistance to antibiotics and disinfectant...