Brain amyloid-β oligomers in ageing and Alzheimer’s disease

• Published in: Brain (London, England : 1878) Vol. 136; no. 5; pp. 1383 - 1398
• Main Authors: Lesné, Sylvain E., Sherman, Mathew A., Grant, Marianne, Kuskowski, Michael, Schneider, Julie A., Bennett, David A., Ashe, Karen H.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2013
• Subjects: Adolescence; Adolescent; Adult; Aged; Aged, 80 and over; Aging - metabolism; Aging - pathology; Aging - physiology; Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Peptides - chemistry; Amyloid beta-Peptides - metabolism; Biological and medical sciences; Brain Chemistry - physiology; Child; Child, Preschool; Cognition - physiology; Cohort Studies; Cross-Sectional Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Follow-Up Studies; Humans; Infant; Male; Medical sciences; Middle Aged; Neurology; Original; Plaque, Amyloid - etiology; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Protein Multimerization; Young Adult; 56; Nervous system diseases; Alzheimer disease; trimer; Ageing; Central nervous system; dimer; amyloid-β; oligomer; Alzheimer; Cerebral disorder; Encephalon; Aβ; Central nervous system disease; Degenerative disease; Amyloid

Alzheimer’s disease begins about two decades before the onset of symptoms or neuron death, and is believed to be caused by pathogenic amyloid-β aggregates that initiate a cascade of molecular events culminating in widespread neurodegeneration. The microtubule binding protein tau may mediate the effe...