Ex vivo optimisation of a heterogeneous speed of sound model of the human skull for non-invasive transcranial focused ultrasound at 1 MHz

• Published in: International journal of hyperthermia Vol. 33; no. 6; pp. 635 - 645
• Main Authors: Marsac, L., Chauvet, D., La Greca, R., Boch, A.-L., Chaumoitre, K., Tanter, M., Aubry, J.-F.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.08.2017
• Subjects: Aged, 80 and over; Computer Science; High intensity focused ultrasound; High-Intensity Focused Ultrasound Ablation; Humans; Life Sciences; Modeling and Simulation; modelling; Models, Biological; Neurons and Cognition; Skull - diagnostic imaging; Sound; thermal ablation; Tomography, X-Ray Computed; ultrasound; High intensity focused ultrasound; thermal ablation; modelling; ultrasound

Transcranial brain therapy has recently emerged as a non-invasive strategy for the treatment of various neurological diseases, such as essential tremor or neurogenic pain. However, treatments require millimetre-scale accuracy. The use of high frequencies (typically ≥1 MHz) decreases the ultrasonic w...