Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection
Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between...
Saved in:
Published in | The Journal of neuroscience Vol. 34; no. 47; pp. 15743 - 15750 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Society for Neuroscience
19.11.2014
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DAT1; SLC6A3), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DAT1 genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DAT1 allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed-accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield. |
---|---|
AbstractList | Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DAT1; SLC6A3), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DAT1 genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DAT1 allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed-accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield. Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DATI; SLC6A3), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DATI genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DATI allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed-accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DATI tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield. Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans ( N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DAT1; SLC6A3 ), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DAT1 genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DAT1 allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed–accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield. |
Author | Tong, Janette H S Johnson, Beth P Newman, Daniel P Cummins, Tarrant D R Goodrich, Jack T T Hawi, Ziarih Pickering, Hayley Fanning, Peter Wagner, Joseph Bellgrove, Mark A Chambers, Christopher D |
Author_xml | – sequence: 1 givenname: Daniel P orcidid: 0000-0001-8240-1876 surname: Newman fullname: Newman, Daniel P organization: Monash University, School of Psychological Sciences, Clayton, Victoria 3800, Australia – sequence: 2 givenname: Tarrant D R surname: Cummins fullname: Cummins, Tarrant D R organization: Monash University, School of Psychological Sciences, Clayton, Victoria 3800, Australia – sequence: 3 givenname: Janette H S surname: Tong fullname: Tong, Janette H S organization: Monash University, School of Psychological Sciences, Clayton, Victoria 3800, Australia – sequence: 4 givenname: Beth P surname: Johnson fullname: Johnson, Beth P organization: Monash University, School of Psychological Sciences, Clayton, Victoria 3800, Australia – sequence: 5 givenname: Hayley surname: Pickering fullname: Pickering, Hayley organization: Monash University, School of Psychological Sciences, Clayton, Victoria 3800, Australia – sequence: 6 givenname: Peter orcidid: 0000-0002-6074-5130 surname: Fanning fullname: Fanning, Peter organization: Monash University, School of Psychological Sciences, Clayton, Victoria 3800, Australia – sequence: 7 givenname: Joseph surname: Wagner fullname: Wagner, Joseph organization: The University of Queensland, Queensland Brain Institute and School of Psychology, Brisbane, Queensland 4072, Australia, and – sequence: 8 givenname: Jack T T surname: Goodrich fullname: Goodrich, Jack T T organization: The University of Queensland, Queensland Brain Institute and School of Psychology, Brisbane, Queensland 4072, Australia, and – sequence: 9 givenname: Ziarih surname: Hawi fullname: Hawi, Ziarih organization: Monash University, School of Psychological Sciences, Clayton, Victoria 3800, Australia – sequence: 10 givenname: Christopher D surname: Chambers fullname: Chambers, Christopher D organization: Cardiff University, School of Psychology, Cardiff CF10 3AT, United Kingdom – sequence: 11 givenname: Mark A surname: Bellgrove fullname: Bellgrove, Mark A email: mark.bellgrove@monash.edu organization: Monash University, School of Psychological Sciences, Clayton, Victoria 3800, Australia, The University of Queensland, Queensland Brain Institute and School of Psychology, Brisbane, Queensland 4072, Australia, and mark.bellgrove@monash.edu |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25411502$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkctOHDEQRa2IKAwkv4C8zKYHv929QYomhIdQkAKsLbe7ZjDqsTu2JxH5ejw8RskuK5erbl3d0jlAeyEGQOiIkjmVjB9ffj-9-3F9s7iYM850Q8WcESreoVmddg0ThO6hGWGaNEposY8Ocn4ghGhC9Qe0z6SgVBI2Q_lrnOzaB8Al2ZCnmAokvIIQy-ME2Gdsc47O2wID_u3LPbZ4rJ9kR_-nthJkn4sNrhpEPNQ6WVd8DHjYJB9W2JYC4bmRYYTn0Uf0fmnHDJ9e30N09-30dnHeXF2fXSy-XDVOCF2aQTLR9p1y3SBp1wtNXctoqzh3tOeEKslaZuVSDNBb1tpaSDXwpaWiE04CP0QnL77Tpl_D4GqOGttMya9tejTRevPvJPh7s4q_jFKkFVxVg8-vBin-3EAuZu2zg3G0AeImG6qZVlq28j-kqrLQLVddlaoXqUsx5wTLXSJKzBau2cE1W7iGCrOFWxeP_r5nt_ZGkz8BfX2mgw |
CitedBy_id | crossref_primary_10_3389_fpsyg_2018_00049 crossref_primary_10_1002_brb3_446 crossref_primary_10_1007_s00213_022_06077_w crossref_primary_10_1016_j_neubiorev_2016_06_032 crossref_primary_10_1038_s41598_022_10634_w crossref_primary_10_1007_s00406_017_0786_x crossref_primary_10_1016_j_biopsycho_2017_07_019 crossref_primary_10_1038_s41597_022_01268_8 crossref_primary_10_1016_j_jstrokecerebrovasdis_2017_02_012 crossref_primary_10_1016_j_neuroscience_2019_05_068 crossref_primary_10_2139_ssrn_3899433 crossref_primary_10_1080_00207454_2017_1385614 |
Cites_doi | 10.1093/cercor/11.1.73 10.1038/sj.mp.4001641 10.1002/ajmg.b.10948 10.1212/WNL.51.5.1395 10.3758/BF03211502 10.1038/217 10.1046/j.1471-4159.2001.00647.x 10.1073/pnas.0504789103 10.1093/cercor/bhs277 10.1016/B978-0-12-286480-3.50014-8 10.1016/j.visres.2005.08.027 10.1016/j.neuropsychologia.2012.08.012 10.1523/JNEUROSCI.04-07-01863.1984 10.1086/319501 10.1523/JNEUROSCI.16-09-03082.1996 10.1037/0096-1523.11.5.583 10.1146/annurev-neuro-062111-150525 10.1038/sj.npp.1301637 10.1002/ajmg.b.30572 10.1212/WNL.37.11.1765 10.1177/0956797611417632 10.1001/archpsyc.63.1.74 10.1186/1471-2156-6-55 10.1038/sj.mp.4002022 10.1086/379378 10.1007/s002130050352 10.1523/JNEUROSCI.14-01-00167.1994 10.1093/brain/aws154 10.1016/0028-3932(89)90166-8 10.1176/appi.ajp.157.2.269 10.1002/cne.1092 10.1016/S0893-133X(99)00099-8 10.1016/j.neuropsychologia.2014.07.005 10.1136/jnnp.66.1.57 10.1016/0006-8993(94)90079-5 10.1038/sj.npp.1300839 10.3758/BRM.42.1.205 10.1016/j.neuropsychologia.2014.01.015 10.1038/sj.tpj.6500026 10.1038/sj.mp.4001921 10.1001/archgenpsychiatry.2009.120 10.1177/0894439311415604 10.1016/j.euroneuro.2004.06.004 10.1016/0028-3932(95)00037-4 |
ContentType | Journal Article |
Copyright | Copyright © 2014 the authors 0270-6474/14/3315743-08$15.00/0. Copyright © 2014 the authors 0270-6474/14/3315743-08$15.00/0 2014 |
Copyright_xml | – notice: Copyright © 2014 the authors 0270-6474/14/3315743-08$15.00/0. – notice: Copyright © 2014 the authors 0270-6474/14/3315743-08$15.00/0 2014 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7TK 5PM |
DOI | 10.1523/JNEUROSCI.2327-14.2014 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Neurosciences Abstracts PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic Neurosciences Abstracts |
DatabaseTitleList | MEDLINE Neurosciences Abstracts MEDLINE - Academic CrossRef |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1529-2401 |
EndPage | 15750 |
ExternalDocumentID | 10_1523_JNEUROSCI_2327_14_2014 25411502 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- -DZ -~X .55 18M 2WC 34G 39C 53G 5GY 5RE 5VS AAFWJ ABBAR ABIVO ACGUR ACNCT ADBBV ADCOW AENEX AFCFT AFHIN AFOSN AHWXS AIZTS ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P GX1 H13 HYE H~9 KQ8 L7B NPM OK1 P0W P2P QZG R.V RHF RHI RPM TFN TR2 W8F WH7 WOQ X7M XJT YBU YHG YKV YNH YSK AAYXX CITATION 7X8 7TK 5PM AETEA |
ID | FETCH-LOGICAL-c447t-d5248b96c9d519b471c8218633c1b30165282a5f4deba28af4d56d3fa1494c5e3 |
IEDL.DBID | RPM |
ISSN | 0270-6474 |
IngestDate | Tue Sep 17 21:07:12 EDT 2024 Fri Oct 25 23:27:28 EDT 2024 Fri Oct 25 06:08:55 EDT 2024 Thu Sep 26 18:06:23 EDT 2024 Sat Sep 28 08:38:41 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 47 |
Keywords | spatial attention genetics DAT1 dopamine selective attention individual differences |
Language | English |
License | Copyright © 2014 the authors 0270-6474/14/3315743-08$15.00/0. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c447t-d5248b96c9d519b471c8218633c1b30165282a5f4deba28af4d56d3fa1494c5e3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: C.D.C. and M.A.B. designed research; D.P.N., T.D.R.C., J.H.S.T., B.P.J., H.P., P.F., J.W., J.T.T.G., Z.H., C.D.C., and M.A.B. performed research; T.D.R.C., J.H.S.T., and Z.H. contributed unpublished reagents/analytic tools; D.P.N., C.D.C., and M.A.B. analyzed data; D.P.N., C.D.C., and M.A.B. wrote the paper. |
ORCID | 0000-0002-6074-5130 0000-0001-8240-1876 |
OpenAccessLink | https://www.jneurosci.org/content/jneuro/34/47/15743.full.pdf |
PMID | 25411502 |
PQID | 1627078369 |
PQPubID | 23479 |
PageCount | 8 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6608436 proquest_miscellaneous_1727675856 proquest_miscellaneous_1627078369 crossref_primary_10_1523_JNEUROSCI_2327_14_2014 pubmed_primary_25411502 |
PublicationCentury | 2000 |
PublicationDate | 2014-Nov-19 2014-11-19 20141119 |
PublicationDateYYYYMMDD | 2014-11-19 |
PublicationDate_xml | – month: 11 year: 2014 text: 2014-Nov-19 day: 19 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of neuroscience |
PublicationTitleAlternate | J Neurosci |
PublicationYear | 2014 |
Publisher | Society for Neuroscience |
Publisher_xml | – name: Society for Neuroscience |
References | Ward (2023041304141882000_34.47.15743.43) 1996; 16 Cook (2023041304141882000_34.47.15743.10) 1995; 56 2023041304141882000_34.47.15743.29 2023041304141882000_34.47.15743.1 2023041304141882000_34.47.15743.28 2023041304141882000_34.47.15743.2 2023041304141882000_34.47.15743.27 2023041304141882000_34.47.15743.3 2023041304141882000_34.47.15743.26 2023041304141882000_34.47.15743.4 2023041304141882000_34.47.15743.5 2023041304141882000_34.47.15743.24 2023041304141882000_34.47.15743.46 2023041304141882000_34.47.15743.23 2023041304141882000_34.47.15743.45 2023041304141882000_34.47.15743.22 2023041304141882000_34.47.15743.44 2023041304141882000_34.47.15743.21 2023041304141882000_34.47.15743.20 Posner (2023041304141882000_34.47.15743.34) 1984; 4 2023041304141882000_34.47.15743.41 2023041304141882000_34.47.15743.40 2023041304141882000_34.47.15743.6 2023041304141882000_34.47.15743.7 2023041304141882000_34.47.15743.8 2023041304141882000_34.47.15743.9 2023041304141882000_34.47.15743.19 2023041304141882000_34.47.15743.18 Iversen (2023041304141882000_34.47.15743.25) 1984; 107 2023041304141882000_34.47.15743.17 2023041304141882000_34.47.15743.39 2023041304141882000_34.47.15743.16 2023041304141882000_34.47.15743.38 2023041304141882000_34.47.15743.15 2023041304141882000_34.47.15743.37 2023041304141882000_34.47.15743.14 2023041304141882000_34.47.15743.36 2023041304141882000_34.47.15743.13 2023041304141882000_34.47.15743.35 2023041304141882000_34.47.15743.12 2023041304141882000_34.47.15743.11 2023041304141882000_34.47.15743.33 2023041304141882000_34.47.15743.32 2023041304141882000_34.47.15743.31 2023041304141882000_34.47.15743.30 Voytko (2023041304141882000_34.47.15743.42) 1994; 14 |
References_xml | – ident: 2023041304141882000_34.47.15743.12 doi: 10.1093/cercor/11.1.73 – ident: 2023041304141882000_34.47.15743.11 doi: 10.1038/sj.mp.4001641 – ident: 2023041304141882000_34.47.15743.30 doi: 10.1002/ajmg.b.10948 – ident: 2023041304141882000_34.47.15743.22 doi: 10.1212/WNL.51.5.1395 – ident: 2023041304141882000_34.47.15743.15 doi: 10.3758/BF03211502 – ident: 2023041304141882000_34.47.15743.14 doi: 10.1038/217 – ident: 2023041304141882000_34.47.15743.29 doi: 10.1046/j.1471-4159.2001.00647.x – ident: 2023041304141882000_34.47.15743.23 doi: 10.1073/pnas.0504789103 – ident: 2023041304141882000_34.47.15743.40 doi: 10.1093/cercor/bhs277 – ident: 2023041304141882000_34.47.15743.19 doi: 10.1016/B978-0-12-286480-3.50014-8 – ident: 2023041304141882000_34.47.15743.45 doi: 10.1016/j.visres.2005.08.027 – ident: 2023041304141882000_34.47.15743.32 doi: 10.1016/j.neuropsychologia.2012.08.012 – volume: 4 start-page: 1863 year: 1984 ident: 2023041304141882000_34.47.15743.34 article-title: Effects of parietal injury on covert orienting of attention publication-title: J Neurosci doi: 10.1523/JNEUROSCI.04-07-01863.1984 contributor: fullname: Posner – ident: 2023041304141882000_34.47.15743.39 doi: 10.1086/319501 – volume: 16 start-page: 3082 year: 1996 ident: 2023041304141882000_34.47.15743.43 article-title: Covert orienting of attention in the rat and the role of striatal dopamine publication-title: J Neurosci doi: 10.1523/JNEUROSCI.16-09-03082.1996 contributor: fullname: Ward – ident: 2023041304141882000_34.47.15743.16 doi: 10.1037/0096-1523.11.5.583 – ident: 2023041304141882000_34.47.15743.33 doi: 10.1146/annurev-neuro-062111-150525 – ident: 2023041304141882000_34.47.15743.3 doi: 10.1038/sj.npp.1301637 – ident: 2023041304141882000_34.47.15743.7 doi: 10.1002/ajmg.b.30572 – ident: 2023041304141882000_34.47.15743.17 doi: 10.1212/WNL.37.11.1765 – ident: 2023041304141882000_34.47.15743.37 doi: 10.1177/0956797611417632 – ident: 2023041304141882000_34.47.15743.6 doi: 10.1001/archpsyc.63.1.74 – ident: 2023041304141882000_34.47.15743.41 doi: 10.1186/1471-2156-6-55 – ident: 2023041304141882000_34.47.15743.2 doi: 10.1038/sj.mp.4002022 – ident: 2023041304141882000_34.47.15743.38 doi: 10.1086/379378 – ident: 2023041304141882000_34.47.15743.44 doi: 10.1007/s002130050352 – volume: 14 start-page: 167 year: 1994 ident: 2023041304141882000_34.47.15743.42 article-title: Basal forebrain lesions in monkeys disrupt attention but not learning and memory publication-title: J Neurosci doi: 10.1523/JNEUROSCI.14-01-00167.1994 contributor: fullname: Voytko – ident: 2023041304141882000_34.47.15743.21 doi: 10.1093/brain/aws154 – ident: 2023041304141882000_34.47.15743.9 doi: 10.1016/0028-3932(89)90166-8 – volume: 107 start-page: 183 year: 1984 ident: 2023041304141882000_34.47.15743.25 article-title: Behavioural effects of manipulation of basal ganglia neurotransmitters publication-title: Ciba Found Symp contributor: fullname: Iversen – ident: 2023041304141882000_34.47.15743.26 doi: 10.1176/appi.ajp.157.2.269 – ident: 2023041304141882000_34.47.15743.27 doi: 10.1002/cne.1092 – ident: 2023041304141882000_34.47.15743.24 doi: 10.1016/S0893-133X(99)00099-8 – ident: 2023041304141882000_34.47.15743.46 doi: 10.1016/j.neuropsychologia.2014.07.005 – volume: 56 start-page: 993 year: 1995 ident: 2023041304141882000_34.47.15743.10 article-title: Association of attention-deficit disorder and the dopamine transporter gene publication-title: Am J Hum Genet contributor: fullname: Cook – ident: 2023041304141882000_34.47.15743.35 doi: 10.1136/jnnp.66.1.57 – ident: 2023041304141882000_34.47.15743.20 doi: 10.1016/0006-8993(94)90079-5 – ident: 2023041304141882000_34.47.15743.1 doi: 10.1038/sj.npp.1300839 – ident: 2023041304141882000_34.47.15743.13 doi: 10.3758/BRM.42.1.205 – ident: 2023041304141882000_34.47.15743.36 doi: 10.1016/j.neuropsychologia.2014.01.015 – ident: 2023041304141882000_34.47.15743.18 doi: 10.1038/sj.tpj.6500026 – ident: 2023041304141882000_34.47.15743.31 doi: 10.1038/sj.mp.4001921 – ident: 2023041304141882000_34.47.15743.4 doi: 10.1001/archgenpsychiatry.2009.120 – ident: 2023041304141882000_34.47.15743.5 doi: 10.1177/0894439311415604 – ident: 2023041304141882000_34.47.15743.8 doi: 10.1016/j.euroneuro.2004.06.004 – ident: 2023041304141882000_34.47.15743.28 doi: 10.1016/0028-3932(95)00037-4 |
SSID | ssj0007017 |
Score | 2.2561753 |
Snippet | Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the... |
SourceID | pubmedcentral proquest crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 15743 |
SubjectTerms | Attention - physiology Cognition - physiology Cues Dopamine Plasma Membrane Transport Proteins - genetics Female Functional Laterality - genetics Functional Laterality - physiology Genotype Humans Male Orientation - physiology Psychomotor Performance - physiology Space Perception - physiology Young Adult |
Title | Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection |
URI | https://www.ncbi.nlm.nih.gov/pubmed/25411502 https://search.proquest.com/docview/1627078369 https://search.proquest.com/docview/1727675856 https://pubmed.ncbi.nlm.nih.gov/PMC6608436 |
Volume | 34 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JT9wwFH5iOPVSFegyZZErVb1lstjxchwNUKAFlU3iFiWOo47EZBATDvDrec9Jhk6ReujNShxl-Z7i73t-C8BXJPGWaEFQCWsCYVUZ5LFQgUki7dIk4nlBDv3TM3l0LU5u0ps1SPtcGB-0b4vpqL6djerpbx9beTezYR8nFv46nUgZacFlOICB4ryX6N3vV0W-zS7KLdRFQokuLRgFV3hyRuFxl5PjEfIIFcTkU4mpMw-qJGJGyeri9Ipx_h04-cdKdPgO3nYUko3bR92ANVdvwta4Rvk8e2TfmA_q9N7yLVjsoyieIZNkL1XM79l3V8_J98qOF6zHx5WMfLIsZz9zykq-nT7hoQu3IIKJlsGaOdv3VXZ9JgRr8xvZuGnagEl26Tvq4Og9XB8eXE2Ogq7PQmCFUE1QponQhZHWlMjnClyurKZWVZzbuOCU74S6LE8rUboiT3SOg1SWvEJQjbCp4x9gvZ7X7hMw0ivaOKsqzQUXwsiiksLZKHGo_FI9hLD_wNldW04jIxmC6GRLdDJCBzVJRugM4UuPQ4aWT9sZee3mD4sslgmVKuLS_GMO0jMvieQQPrbYLe_bgz4EtYLqcgJV3l49gwbpK3B3Bvj5v6_chjf0cpTUGJsdWG_uH9wuspum2IPBj3O95236GZr6-fg |
link.rule.ids | 230,315,733,786,790,891,27946,27947,53816,53818 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6VcoALr_IIz0VC3Pzc9dp7jFJKUpII0Rb1ZnnXaxHROFXjHOivZ2ZtB1IkJLitvLas1Yy93zf7zQzAOwTxhmCBVwmjPGHS0isikXoqDjObxCEvNAX0Z3M5PhPH58n5HiR9LowT7Ru98OuLpV8vvjlt5eXSBL1OLPg8G0kZZoLL4BbcTujgqyfp3Q84DV2jXSRcyIxEKrrEYKRcwfGcBHIno4mPSCL1IoqqRNSbB3kSYaN4d3v6A3PelE7-thcd3Yev_SpaCcp3f9No31zfKPD4z8t8APc6dMqG7fRD2LP1IzgY1sjMlz_Ye-b0oi4QfwDrQ-TbSwSp7FeB9Cv20dYrCuuyyZr1prclo3AvK9i0oITni8U1Xvpi14Rd0elYs2KHroCvS7JgbeokGzZNq8VkJ65ZD44ew9nRh9PR2OtaOHhGiLTxyiQWmVbSqBKhosad0GTUBYtzE2lOqVRI-YqkEqXVRZwVOEhkySv0FyVMYvkT2K9XtX0GjKhQpqxJq4wLLoSSupLCmjC2SCqTbABBb7n8sq3UkRPDQbPnW7PnZHakOzmZfQBvewPn-FHRSUlR29VmnUcypipIXKq_3IPIz7EtOYCnrVNs39t70wDSHXfZ3kBFvXdn0Alcce_O6M__-8k3cGd8Opvm08n80wu4Swul3MlIvYT95mpjXyGIavRr98n8BNssGwk |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB5BkRAXXuURnouEuPm567X3GCWEprRRRalUcbG867WIaJyocQ701zOztkNTJA69rey1rNXMer9v_M0MwEcE8YZggVcJozxh0tIrIpF6Kg4zm8QhLzQF9I9n8uBMHJ4n59dafTnRvtFzv75Y-PX8p9NWrhYm6HViwcnxSMowE1wGq7IK7sK9hE6dnqh3H-E0dM12kXQhOxKp6JKDkXYFhzMSyZ2Opj6iidSLKLISUX8e5EqEj-LdI-of3HlTPnntPJo8gh_9SloZyi9_02jfXN0o8nirpT6Ghx1KZcN2yhO4Y-unsD-skaEvfrNPzOlGXUB-H9Zj5N0LBKvsb6H0S_bF1ksK77LpmvUuYEtGYV9WsKOCEp8v5ld46ZtdE4ZF52PNko1dIV-XbMHaFEo2bJpWk8lOXdMeHD2Ds8nn76MDr2vl4Bkh0sYrk1hkWkmjSoSMGk9Ek1E3LM5NpDmlVCH1K5JKlFYXcVbgIJElr9BvlDCJ5c9hr17W9iUwokSZsiatMi64EErqSgprwtgiuUyyAQS99fJVW7EjJ6aDps-3ps_J9Eh7cjL9AD70Rs5xc9Efk6K2y806j2RM1ZC4VP-ZgwjQsS45gBetY2zf23vUANIdl9lOoOLeu3fQEVyR787wr2795Hu4fzKe5EfT2dfX8IDWSSmUkXoDe83lxr5FLNXod27X_AG0fR2J |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dopamine+transporter+genotype+is+associated+with+a+lateralized+resistance+to+distraction+during+attention+selection&rft.jtitle=The+Journal+of+neuroscience&rft.au=Newman%2C+Daniel+P&rft.au=Cummins%2C+Tarrant+D+R&rft.au=Tong%2C+Janette+H+S&rft.au=Johnson%2C+Beth+P&rft.date=2014-11-19&rft.eissn=1529-2401&rft.volume=34&rft.issue=47&rft.spage=15743&rft.epage=15750&rft_id=info:doi/10.1523%2FJNEUROSCI.2327-14.2014&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-6474&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-6474&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-6474&client=summon |