micro1 gene is necessary and sufficient for micromere differentiation and mid/hindgut-inducing activity in the sea urchin embryo

• Published in: Development genes and evolution Vol. 215; no. 9; pp. 450 - 459
• Main Authors: Yamazaki, Atsuko, Kawabata, Rika, Shiomi, Kosuke, Amemiya, Shonan, Sawaguchi, Masaya, Mitsunaga-Nakatsubo, Keiko, Yamaguchi, Masaaki
• Format: Journal Article
• Language: English
• Published: Germany Berlin/Heidelberg : Springer-Verlag 01.09.2005; Springer Nature B.V
• Subjects: Active activator; Animals; Blastomeres - cytology; Cell Differentiation - genetics; Chimera - embryology; Chimera - genetics; Echinoidea; Embryo, Nonmammalian - cytology; Embryo, Nonmammalian - metabolism; Embryo, Nonmammalian - physiology; Embryos; Gene Expression Regulation, Developmental; Genes, Homeobox - genetics; Genes, Homeobox - physiology; homeotic genes; In Situ Hybridization; Mesoderm - cytology; Micromere specification; Phenotype; Proteins; Sea Urchins - embryology; Sea Urchins - genetics; Transcriptional repressor; VP16 activation domain

In the sea urchin embryo, micromeres have two distinct functions: they differentiate cell autonomously into the skeletogenic mesenchyme cells and act as an organizing center that induces endomesoderm formation. We demonstrated that micro1 controls micromere specification as a transcriptional repress...