Tetrathiomolybdate, a copper chelator inhibited imiquimod-induced skin inflammation in mice

• Published in: Journal of dermatological science Vol. 92; no. 1; pp. 30 - 37
• Main Authors: Hsu, Peng-Yang, Yen, Hsu-Heng, Yang, Tao-Hsiang, Su, Che-Chun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2018
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Chelating Agents - pharmacology; Copper; Copper - metabolism; Cytokines - metabolism; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases - metabolism; Imiquimod; Inflammation Mediators - metabolism; Keratinocytes - drug effects; Keratinocytes - immunology; Keratinocytes - metabolism; Male; Mice, Inbred C57BL; Molybdenum - pharmacology; Phosphorylation; Psoriasis; Psoriasis - chemically induced; Psoriasis - immunology; Psoriasis - metabolism; Psoriasis - prevention & control; Signal Transduction - drug effects; Skin - drug effects; Skin - immunology; Skin - metabolism; Skin - pathology; Spleen - drug effects; Spleen - immunology; Spleen - metabolism; STAT3 Transcription Factor - metabolism; Tetrathiomolybdate; Tetrathiomolybdate; Psoriasis; Copper; Imiquimod

•Tetrathiomolybdate (TM) inhibited imiquimod-induced psoriasiform lesions in mice.•TM decreased cytokine levels in inflamed skin, splenocyte, and draining lymph node.•TM inhibited signals activation (Erk1/2 and STAT3) in keratinocyte and splenocyte. Copper is an essential metal for maintenance of ma...