miR-497-5p inhibits gastric cancer cell proliferation and growth through targeting PDK3
MicroRNA plays an important role in gastric cancer (GC) development, while the function of miR-497-5p in this disease remains unknown. In the present study, we demonstrated miR-497-5p as a tumor suppressive microRNA in GC. miR-497-5p was down-regulated in GC tissues and its expression was associated...
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| Published in | Bioscience reports Vol. 39; no. 9 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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| Abstract | MicroRNA plays an important role in gastric cancer (GC) development, while the function of miR-497-5p in this disease remains unknown. In the present study, we demonstrated miR-497-5p as a tumor suppressive microRNA in GC. miR-497-5p was down-regulated in GC tissues and its expression was associated with the disease stage. Inhibition of miR-497-5p promoted GC cell proliferation and growth. By contrast, miR-497-5p ectopic expression suppressed the proliferation and growth of GC cells. In addition, miR-497-5p inhibited DNA synthesis and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the proliferation of GC cells. Our study revealed that miR-497-5p inhibited GC cell proliferation and growth via targeting PDK3. |
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| AbstractList | MicroRNA plays an important role in gastric cancer (GC) development, while the function of miR-497-5p in this disease remains unknown. In the present study, we demonstrated miR-497-5p as a tumor suppressive microRNA in GC. miR-497-5p was down-regulated in GC tissues and its expression was associated with the disease stage. Inhibition of miR-497-5p promoted GC cell proliferation and growth. By contrast, miR-497-5p ectopic expression suppressed the proliferation and growth of GC cells. In addition, miR-497-5p inhibited DNA synthesis and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the proliferation of GC cells. Our study revealed that miR-497-5p inhibited GC cell proliferation and growth via targeting PDK3. MicroRNA plays an important role in gastric cancer (GC) development, while the function of miR-497-5p in this disease remains unknown. In the present study, we demonstrated miR-497-5p as a tumor suppressive microRNA in GC. miR-497-5p was down-regulated in GC tissues and its expression was associated with the disease stage. Inhibition of miR-497-5p promoted GC cell proliferation and growth. By contrast, miR-497-5p ectopic expression suppressed the proliferation and growth of GC cells. In addition, miR-497-5p inhibited DNA synthesis and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the proliferation of GC cells. Our study revealed that miR-497-5p inhibited GC cell proliferation and growth via targeting PDK3.MicroRNA plays an important role in gastric cancer (GC) development, while the function of miR-497-5p in this disease remains unknown. In the present study, we demonstrated miR-497-5p as a tumor suppressive microRNA in GC. miR-497-5p was down-regulated in GC tissues and its expression was associated with the disease stage. Inhibition of miR-497-5p promoted GC cell proliferation and growth. By contrast, miR-497-5p ectopic expression suppressed the proliferation and growth of GC cells. In addition, miR-497-5p inhibited DNA synthesis and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the proliferation of GC cells. Our study revealed that miR-497-5p inhibited GC cell proliferation and growth via targeting PDK3. |
| Author | Zang, Rongjia Feng, Lan Wang, Qingdong Wang, Jianjie Cheng, Kai |
| Author_xml | – sequence: 1 givenname: Lan surname: Feng fullname: Feng, Lan organization: Department of Infection Medicine, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang Province, People’s Republic of China – sequence: 2 givenname: Kai surname: Cheng fullname: Cheng, Kai organization: Department of Infection Medicine, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang Province, People’s Republic of China – sequence: 3 givenname: Rongjia surname: Zang fullname: Zang, Rongjia organization: Department of Infection Medicine, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang Province, People’s Republic of China – sequence: 4 givenname: Qingdong surname: Wang fullname: Wang, Qingdong organization: Department of Infection Medicine, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang Province, People’s Republic of China – sequence: 5 givenname: Jianjie orcidid: 0000-0003-0074-9073 surname: Wang fullname: Wang, Jianjie organization: Department of Immunology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang Province, People’s Republic of China |
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| Keywords | DNA synthesis PDK3 apoptosis gastric cancer cell cycle miR-497-5p |
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