Screening and validation of lncRNAs and circRNAs as miRNA sponges

• Published in: Briefings in bioinformatics Vol. 18; no. 5; pp. 780 - 788
• Main Authors: Militello, Giuseppe, Weirick, Tyler, John, David, Döring, Claudia, Dimmeler, Stefanie, Uchida, Shizuka
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2017; Oxford Publishing Limited (England)
• Subjects: Bioinformatics; BTG2 protein; Cell survival; Computational Biology; MicroRNAs; miRNA; Regulators; RNA, Long Noncoding - genetics; Sequestering; Sponges; Transcription; microRNA; lncRNA; circular RNA; transcriptome

Abstract Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are...