Screening and validation of lncRNAs and circRNAs as miRNA sponges
Abstract Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are...
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| Published in | Briefings in bioinformatics Vol. 18; no. 5; pp. 780 - 788 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Oxford University Press
01.09.2017
Oxford Publishing Limited (England) |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Abstract
Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are collectively called 'competing endogenous RNAs' or 'miRNA sponges'. In this study, we screened for lncRNAs that may act as miRNA sponges using the publicly available data sets and databases. To uncover the roles of miRNA sponges, loss-of-function experiments were conducted, which revealed the biological roles as miRNA sponges. LINC00324 is important for the cell survival by binding to miR-615-5p leading to the de-repression of its target BTG2. LOC400043 controls several biological functions via sequestering miR-28-3p and miR-96-5p, thereby changing the expressions of transcriptional regulators. Finally, we also screened for circular RNAs (circRNAs) that may function as miRNA sponges. The results were negative at least for the selected circRNAs in this study. In conclusion, miRNA sponges can be identified by applying a series of bioinformatics techniques and validated with biological experiments. |
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| AbstractList | Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are collectively called ‘competing endogenous RNAs’ or ‘miRNA sponges’. In this study, we screened for lncRNAs that may act as miRNA sponges using the publicly available data sets and databases. To uncover the roles of miRNA sponges, loss-of-function experiments were conducted, which revealed the biological roles as miRNA sponges. LINC00324 is important for the cell survival by binding to miR-615-5p leading to the de-repression of its target BTG2. LOC400043 controls several biological functions via sequestering miR-28-3p and miR-96-5p, thereby changing the expressions of transcriptional regulators. Finally, we also screened for circular RNAs (circRNAs) that may function as miRNA sponges. The results were negative at least for the selected circRNAs in this study. In conclusion, miRNA sponges can be identified by applying a series of bioinformatics techniques and validated with biological experiments. Abstract Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are collectively called 'competing endogenous RNAs' or 'miRNA sponges'. In this study, we screened for lncRNAs that may act as miRNA sponges using the publicly available data sets and databases. To uncover the roles of miRNA sponges, loss-of-function experiments were conducted, which revealed the biological roles as miRNA sponges. LINC00324 is important for the cell survival by binding to miR-615-5p leading to the de-repression of its target BTG2. LOC400043 controls several biological functions via sequestering miR-28-3p and miR-96-5p, thereby changing the expressions of transcriptional regulators. Finally, we also screened for circular RNAs (circRNAs) that may function as miRNA sponges. The results were negative at least for the selected circRNAs in this study. In conclusion, miRNA sponges can be identified by applying a series of bioinformatics techniques and validated with biological experiments. Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are collectively called 'competing endogenous RNAs' or 'miRNA sponges'. In this study, we screened for lncRNAs that may act as miRNA sponges using the publicly available data sets and databases. To uncover the roles of miRNA sponges, loss-of-function experiments were conducted, which revealed the biological roles as miRNA sponges. LINC00324 is important for the cell survival by binding to miR-615-5p leading to the de-repression of its target BTG2. LOC400043 controls several biological functions via sequestering miR-28-3p and miR-96-5p, thereby changing the expressions of transcriptional regulators. Finally, we also screened for circular RNAs (circRNAs) that may function as miRNA sponges. The results were negative at least for the selected circRNAs in this study. In conclusion, miRNA sponges can be identified by applying a series of bioinformatics techniques and validated with biological experiments.Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs (lncRNAs). These two classes of ncRNAs interact to a certain extent, as some lncRNAs bind to miRs to sequester them. Such lncRNAs are collectively called 'competing endogenous RNAs' or 'miRNA sponges'. In this study, we screened for lncRNAs that may act as miRNA sponges using the publicly available data sets and databases. To uncover the roles of miRNA sponges, loss-of-function experiments were conducted, which revealed the biological roles as miRNA sponges. LINC00324 is important for the cell survival by binding to miR-615-5p leading to the de-repression of its target BTG2. LOC400043 controls several biological functions via sequestering miR-28-3p and miR-96-5p, thereby changing the expressions of transcriptional regulators. Finally, we also screened for circular RNAs (circRNAs) that may function as miRNA sponges. The results were negative at least for the selected circRNAs in this study. In conclusion, miRNA sponges can be identified by applying a series of bioinformatics techniques and validated with biological experiments. |
| Author | Weirick, Tyler Militello, Giuseppe Uchida, Shizuka Döring, Claudia John, David Dimmeler, Stefanie |
| Author_xml | – sequence: 1 givenname: Giuseppe surname: Militello fullname: Militello, Giuseppe organization: Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main, Germany – sequence: 2 givenname: Tyler surname: Weirick fullname: Weirick, Tyler organization: Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main, Germany – sequence: 3 givenname: David surname: John fullname: John, David organization: Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main, Germany – sequence: 4 givenname: Claudia surname: Döring fullname: Döring, Claudia organization: Dr. Senckenberg Institute of Pathology, Goethe University Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main, Germany – sequence: 5 givenname: Stefanie surname: Dimmeler fullname: Dimmeler, Stefanie organization: Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main, Germany – sequence: 6 givenname: Shizuka surname: Uchida fullname: Uchida, Shizuka email: heart.lncrna@gmail.com organization: Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27373735$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1186/s13059-014-0409-z 10.1093/nar/gkt1181 10.1016/j.molcel.2013.08.027 10.1093/nar/gkt1057 10.1093/bioinformatics/btg405 10.1161/CIRCRESAHA.116.305510 10.1093/bioinformatics/18.suppl_1.S96 10.1038/nbt.2024 10.1038/onc.2014.131 10.1038/nature11928 10.1038/nrcardio.2014.207 10.1016/j.cell.2011.09.028 10.1371/journal.pone.0098965 10.1515/hsz-2014-0116 10.1093/nar/gkv007 10.1093/nar/gkr1110 10.1126/science.1090095 10.1186/s12864-015-1273-2 10.1038/emboj.2011.359 10.1016/j.addr.2014.12.006 10.1093/nar/gks877 10.1161/CIRCRESAHA.114.303265 10.1161/CIRCRESAHA.116.302521 10.1038/nature11993 10.1093/biostatistics/4.2.249 10.1093/nar/gkv1258 10.1096/fj.14-259952 10.1093/bioinformatics/btv410 10.1093/nar/gku887 10.1261/rna.043687.113 10.1093/nar/gkt1248 10.1093/nar/gks596 10.3892/ijo.2014.2765 10.1007/s12015-011-9294-y 10.1016/j.ygyno.2014.02.033 10.1038/srep02535 10.1111/jcmm.12243 10.1016/j.gene.2015.05.065 10.1161/ATVBAHA.113.300138 10.1161/CIRCRESAHA.115.306319 10.1016/j.molcel.2010.05.004 10.1038/35057062 10.1093/nar/gkm995 10.1038/nchembio.1713 10.1093/nar/gku1215 10.1016/j.molcel.2014.03.045 10.1093/bioinformatics/btu325 |
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| Keywords | microRNA lncRNA circular RNA transcriptome |
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| References | 2016070317180965000_bbw053v1.30 2016070317180965000_bbw053v1.31 2016070317180965000_bbw053v1.10 2016070317180965000_bbw053v1.32 2016070317180965000_bbw053v1.11 2016070317180965000_bbw053v1.33 2016070317180965000_bbw053v1.12 2016070317180965000_bbw053v1.34 2016070317180965000_bbw053v1.13 2016070317180965000_bbw053v1.35 2016070317180965000_bbw053v1.2 2016070317180965000_bbw053v1.14 2016070317180965000_bbw053v1.36 2016070317180965000_bbw053v1.1 2016070317180965000_bbw053v1.15 2016070317180965000_bbw053v1.37 2016070317180965000_bbw053v1.4 2016070317180965000_bbw053v1.3 2016070317180965000_bbw053v1.6 2016070317180965000_bbw053v1.5 2016070317180965000_bbw053v1.8 Imig (2016070317180965000_bbw053v1.9) 2015; 11 2016070317180965000_bbw053v1.16 2016070317180965000_bbw053v1.38 2016070317180965000_bbw053v1.17 2016070317180965000_bbw053v1.39 2016070317180965000_bbw053v1.18 2016070317180965000_bbw053v1.19 Dueck (2016070317180965000_bbw053v1.20) 2014; 395 2016070317180965000_bbw053v1.42 2016070317180965000_bbw053v1.21 Mao (2016070317180965000_bbw053v1.41) 2015; 46 2016070317180965000_bbw053v1.43 2016070317180965000_bbw053v1.22 2016070317180965000_bbw053v1.44 2016070317180965000_bbw053v1.23 2016070317180965000_bbw053v1.45 2016070317180965000_bbw053v1.24 2016070317180965000_bbw053v1.46 2016070317180965000_bbw053v1.25 2016070317180965000_bbw053v1.47 2016070317180965000_bbw053v1.26 2016070317180965000_bbw053v1.40 Boon (2016070317180965000_bbw053v1.7) 2015; 12 2016070317180965000_bbw053v1.27 2016070317180965000_bbw053v1.28 2016070317180965000_bbw053v1.29 |
| References_xml | – ident: 2016070317180965000_bbw053v1.47 doi: 10.1186/s13059-014-0409-z – ident: 2016070317180965000_bbw053v1.36 doi: 10.1093/nar/gkt1181 – ident: 2016070317180965000_bbw053v1.8 doi: 10.1016/j.molcel.2013.08.027 – ident: 2016070317180965000_bbw053v1.23 doi: 10.1093/nar/gkt1057 – ident: 2016070317180965000_bbw053v1.34 doi: 10.1093/bioinformatics/btg405 – ident: 2016070317180965000_bbw053v1.15 doi: 10.1161/CIRCRESAHA.116.305510 – ident: 2016070317180965000_bbw053v1.35 doi: 10.1093/bioinformatics/18.suppl_1.S96 – ident: 2016070317180965000_bbw053v1.2 doi: 10.1038/nbt.2024 – ident: 2016070317180965000_bbw053v1.12 doi: 10.1038/onc.2014.131 – ident: 2016070317180965000_bbw053v1.45 doi: 10.1038/nature11928 – volume: 12 start-page: 135 year: 2015 ident: 2016070317180965000_bbw053v1.7 article-title: MicroRNAs in myocardial infarction publication-title: Nat Rev Cardiol doi: 10.1038/nrcardio.2014.207 – ident: 2016070317180965000_bbw053v1.10 doi: 10.1016/j.cell.2011.09.028 – ident: 2016070317180965000_bbw053v1.17 doi: 10.1371/journal.pone.0098965 – volume: 395 start-page: 611 year: 2014 ident: 2016070317180965000_bbw053v1.20 article-title: Assembly and function of small RNA - argonaute protein complexes publication-title: Biol Chem doi: 10.1515/hsz-2014-0116 – ident: 2016070317180965000_bbw053v1.33 doi: 10.1093/nar/gkv007 – ident: 2016070317180965000_bbw053v1.31 doi: 10.1093/nar/gkr1110 – ident: 2016070317180965000_bbw053v1.19 doi: 10.1126/science.1090095 – ident: 2016070317180965000_bbw053v1.24 doi: 10.1186/s12864-015-1273-2 – ident: 2016070317180965000_bbw053v1.43 doi: 10.1038/emboj.2011.359 – ident: 2016070317180965000_bbw053v1.5 doi: 10.1016/j.addr.2014.12.006 – ident: 2016070317180965000_bbw053v1.30 doi: 10.1093/nar/gks877 – ident: 2016070317180965000_bbw053v1.28 doi: 10.1161/CIRCRESAHA.114.303265 – ident: 2016070317180965000_bbw053v1.3 doi: 10.1161/CIRCRESAHA.116.302521 – ident: 2016070317180965000_bbw053v1.44 doi: 10.1038/nature11993 – ident: 2016070317180965000_bbw053v1.32 doi: 10.1093/biostatistics/4.2.249 – ident: 2016070317180965000_bbw053v1.40 doi: 10.1093/nar/gkv1258 – ident: 2016070317180965000_bbw053v1.13 doi: 10.1096/fj.14-259952 – ident: 2016070317180965000_bbw053v1.38 doi: 10.1093/bioinformatics/btv410 – ident: 2016070317180965000_bbw053v1.42 doi: 10.1093/nar/gku887 – ident: 2016070317180965000_bbw053v1.46 doi: 10.1261/rna.043687.113 – ident: 2016070317180965000_bbw053v1.21 doi: 10.1093/nar/gkt1248 – ident: 2016070317180965000_bbw053v1.29 doi: 10.1093/nar/gks596 – volume: 46 start-page: 459 year: 2015 ident: 2016070317180965000_bbw053v1.41 article-title: BTG2: a rising star of tumor suppressors (review) publication-title: Int J Oncol doi: 10.3892/ijo.2014.2765 – ident: 2016070317180965000_bbw053v1.4 doi: 10.1007/s12015-011-9294-y – ident: 2016070317180965000_bbw053v1.11 doi: 10.1016/j.ygyno.2014.02.033 – ident: 2016070317180965000_bbw053v1.14 doi: 10.1038/srep02535 – ident: 2016070317180965000_bbw053v1.16 doi: 10.1111/jcmm.12243 – ident: 2016070317180965000_bbw053v1.37 doi: 10.1016/j.gene.2015.05.065 – ident: 2016070317180965000_bbw053v1.6 doi: 10.1161/ATVBAHA.113.300138 – ident: 2016070317180965000_bbw053v1.25 doi: 10.1161/CIRCRESAHA.115.306319 – ident: 2016070317180965000_bbw053v1.26 doi: 10.1016/j.molcel.2010.05.004 – ident: 2016070317180965000_bbw053v1.1 doi: 10.1038/35057062 – ident: 2016070317180965000_bbw053v1.27 doi: 10.1093/nar/gkm995 – volume: 11 start-page: 107 year: 2015 ident: 2016070317180965000_bbw053v1.9 article-title: miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction publication-title: Nat Chem Biol doi: 10.1038/nchembio.1713 – ident: 2016070317180965000_bbw053v1.39 doi: 10.1093/nar/gku1215 – ident: 2016070317180965000_bbw053v1.18 doi: 10.1016/j.molcel.2014.03.045 – ident: 2016070317180965000_bbw053v1.22 doi: 10.1093/bioinformatics/btu325 |
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| Snippet | Abstract
Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long... Intensive research in past two decades has uncovered the presence and importance of noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs... |
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| SubjectTerms | Bioinformatics BTG2 protein Cell survival Computational Biology MicroRNAs miRNA Regulators RNA, Long Noncoding - genetics Sequestering Sponges Transcription |
| Title | Screening and validation of lncRNAs and circRNAs as miRNA sponges |
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