Categorizing Extrachromosomal Circular DNA as Biomarkers in Serum of Cancer

Extrachromosomal circular DNA (eccDNA), a double-stranded circular DNA molecule found in multiple organisms, has garnered an increasing amount of attention in recent years due to its close association with the initiation, malignant progression, and heterogeneous evolution of cancer. The presence of...

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Published inBiomolecules (Basel, Switzerland) Vol. 14; no. 4; p. 488
Main Authors Deng, Enze, Fan, Xiaoying
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2024
Subjects
biomarker
Biomarkers
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Biopsy
Cancer
Cancer therapies
Cell division
Chromosomes
Circular DNA
Diagnosis
DNA, Circular - blood
DNA, Circular - genetics
extrachromosomal circular DNA
Gene amplification
Genetic aspects
Genomes
Health aspects
Humans
Liquid Biopsy - methods
Microscopy
Neoplasms - blood
Neoplasms - diagnosis
Neoplasms - genetics
Prognosis
Roles
serum
Tumorigenesis
Tumors
China
cancer
biomarker
serum
extrachromosomal circular DNA
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Abstract Extrachromosomal circular DNA (eccDNA), a double-stranded circular DNA molecule found in multiple organisms, has garnered an increasing amount of attention in recent years due to its close association with the initiation, malignant progression, and heterogeneous evolution of cancer. The presence of eccDNA in serum assists in non-invasive tumor diagnosis as a biomarker that can be assessed via liquid biopsies. Furthermore, the specific expression patterns of eccDNA provide new insights into personalized cancer therapy. EccDNA plays a pivotal role in tumorigenesis, development, diagnosis, and treatment. In this review, we comprehensively outline the research trajectory of eccDNA, discuss its role as a diagnostic and prognostic biomarker, and elucidate its regulatory mechanisms in cancer. In particular, we emphasize the potential application value of eccDNA in cancer diagnosis and treatment and anticipate the development of novel tumor diagnosis strategies based on serum eccDNA in the future.
AbstractList Extrachromosomal circular DNA (eccDNA), a double-stranded circular DNA molecule found in multiple organisms, has garnered an increasing amount of attention in recent years due to its close association with the initiation, malignant progression, and heterogeneous evolution of cancer. The presence of eccDNA in serum assists in non-invasive tumor diagnosis as a biomarker that can be assessed via liquid biopsies. Furthermore, the specific expression patterns of eccDNA provide new insights into personalized cancer therapy. EccDNA plays a pivotal role in tumorigenesis, development, diagnosis, and treatment. In this review, we comprehensively outline the research trajectory of eccDNA, discuss its role as a diagnostic and prognostic biomarker, and elucidate its regulatory mechanisms in cancer. In particular, we emphasize the potential application value of eccDNA in cancer diagnosis and treatment and anticipate the development of novel tumor diagnosis strategies based on serum eccDNA in the future.
Extrachromosomal circular DNA (eccDNA), a double-stranded circular DNA molecule found in multiple organisms, has garnered an increasing amount of attention in recent years due to its close association with the initiation, malignant progression, and heterogeneous evolution of cancer. The presence of eccDNA in serum assists in non-invasive tumor diagnosis as a biomarker that can be assessed via liquid biopsies. Furthermore, the specific expression patterns of eccDNA provide new insights into personalized cancer therapy. EccDNA plays a pivotal role in tumorigenesis, development, diagnosis, and treatment. In this review, we comprehensively outline the research trajectory of eccDNA, discuss its role as a diagnostic and prognostic biomarker, and elucidate its regulatory mechanisms in cancer. In particular, we emphasize the potential application value of eccDNA in cancer diagnosis and treatment and anticipate the development of novel tumor diagnosis strategies based on serum eccDNA in the future.Extrachromosomal circular DNA (eccDNA), a double-stranded circular DNA molecule found in multiple organisms, has garnered an increasing amount of attention in recent years due to its close association with the initiation, malignant progression, and heterogeneous evolution of cancer. The presence of eccDNA in serum assists in non-invasive tumor diagnosis as a biomarker that can be assessed via liquid biopsies. Furthermore, the specific expression patterns of eccDNA provide new insights into personalized cancer therapy. EccDNA plays a pivotal role in tumorigenesis, development, diagnosis, and treatment. In this review, we comprehensively outline the research trajectory of eccDNA, discuss its role as a diagnostic and prognostic biomarker, and elucidate its regulatory mechanisms in cancer. In particular, we emphasize the potential application value of eccDNA in cancer diagnosis and treatment and anticipate the development of novel tumor diagnosis strategies based on serum eccDNA in the future.
Audience Academic
Author Deng, Enze
Fan, Xiaoying
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Keywords cancer
biomarker
serum
extrachromosomal circular DNA
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Snippet Extrachromosomal circular DNA (eccDNA), a double-stranded circular DNA molecule found in multiple organisms, has garnered an increasing amount of attention in...
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gale
pubmed
crossref
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Aggregation Database
Index Database
StartPage 488
SubjectTerms biomarker
Biomarkers
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Biopsy
Cancer
Cancer therapies
Cell division
Chromosomes
Circular DNA
Diagnosis
DNA, Circular - blood
DNA, Circular - genetics
extrachromosomal circular DNA
Gene amplification
Genetic aspects
Genomes
Health aspects
Humans
Liquid Biopsy - methods
Microscopy
Neoplasms - blood
Neoplasms - diagnosis
Neoplasms - genetics
Prognosis
Roles
serum
Tumorigenesis
Tumors
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Title Categorizing Extrachromosomal Circular DNA as Biomarkers in Serum of Cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/38672504
https://www.proquest.com/docview/3046592954
https://www.proquest.com/docview/3047950831
https://doaj.org/article/d94fbc3b2a3c453b8f956dc0badf4a90
Volume 14
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