Circadian clock genes as promising therapeutic targets for autoimmune diseases

Circadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects on both innate and adaptive immunity, which significantly enhance pro-inflammatory responses and susceptibility to autoimmun...

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Published inAutoimmunity reviews Vol. 20; no. 8; p. 102866
Main Authors Xiang, Kun, Xu, Zhiwei, Hu, Yu-Qian, He, Yi-Sheng, Wu, Guo-Cui, Li, Tian-Yu, Wang, Xue-Rong, Ding, Li-Hong, Zhang, Qin, Tao, Sha-Sha, Ye, Dong-Qing, Pan, Hai-Feng, Wang, De-Guang
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.08.2021
Subjects
Allergy and Immunology
Autoimmune diseases
Autoimmunity
Circadian clock genes
Circadian rhythm
Inflammation
Therapeutic target
Autoimmunity
Circadian clock genes
Inflammation
Circadian rhythm
Autoimmune diseases
Therapeutic target
Online AccessGet full text
ISSN1568-9972
1568-9972
DOI10.1016/j.autrev.2021.102866

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Abstract Circadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects on both innate and adaptive immunity, which significantly enhance pro-inflammatory responses and susceptibility to autoimmune diseases via strictly controlling the individual cellular components of the immune system that initiate and perpetuate the inflammation pathways. Autoimmune diseases, especially rheumatoid arthritis (RA), often exhibit substantial circadian oscillations, and circadian rhythm is involved in the onset and progression of autoimmune diseases. Mounting evidence indicate that the synthetic ligands of circadian clock genes have the property of reducing the susceptibility and clinical severity of subjects. This review supplies an overview of the roles of circadian clock genes in the pathology of autoimmune diseases, including BMAL1, CLOCK, PER, CRY, REV-ERBα, and ROR. Furthermore, summarized some circadian clock genes as candidate genes for autoimmune diseases and current advancement on therapy of autoimmune diseases with synthetic ligands of circadian clock genes. The existing body of knowledge demonstrates that circadian clock genes are inextricably linked to autoimmune diseases. Future research should pay attention to improve the quality of life of patients with autoimmune diseases and reduce the effects of drug preparation on the normal circadian rhythms.
AbstractList Circadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects on both innate and adaptive immunity, which significantly enhance pro-inflammatory responses and susceptibility to autoimmune diseases via strictly controlling the individual cellular components of the immune system that initiate and perpetuate the inflammation pathways. Autoimmune diseases, especially rheumatoid arthritis (RA), often exhibit substantial circadian oscillations, and circadian rhythm is involved in the onset and progression of autoimmune diseases. Mounting evidence indicate that the synthetic ligands of circadian clock genes have the property of reducing the susceptibility and clinical severity of subjects. This review supplies an overview of the roles of circadian clock genes in the pathology of autoimmune diseases, including BMAL1, CLOCK, PER, CRY, REV-ERBα, and ROR. Furthermore, summarized some circadian clock genes as candidate genes for autoimmune diseases and current advancement on therapy of autoimmune diseases with synthetic ligands of circadian clock genes. The existing body of knowledge demonstrates that circadian clock genes are inextricably linked to autoimmune diseases. Future research should pay attention to improve the quality of life of patients with autoimmune diseases and reduce the effects of drug preparation on the normal circadian rhythms.
AbstractCircadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects on both innate and adaptive immunity, which significantly enhance pro-inflammatory responses and susceptibility to autoimmune diseases via strictly controlling the individual cellular components of the immune system that initiate and perpetuate the inflammation pathways. Autoimmune diseases, especially rheumatoid arthritis (RA), often exhibit substantial circadian oscillations, and circadian rhythm is involved in the onset and progression of autoimmune diseases. Mounting evidence indicate that the synthetic ligands of circadian clock genes have the property of reducing the susceptibility and clinical severity of subjects. This review supplies an overview of the roles of circadian clock genes in the pathology of autoimmune diseases, including BMAL1, CLOCK, PER, CRY, REV-ERBα, and ROR. Furthermore, summarized some circadian clock genes as candidate genes for autoimmune diseases and current advancement on therapy of autoimmune diseases with synthetic ligands of circadian clock genes. The existing body of knowledge demonstrates that circadian clock genes are inextricably linked to autoimmune diseases. Future research should pay attention to improve the quality of life of patients with autoimmune diseases and reduce the effects of drug preparation on the normal circadian rhythms.
ArticleNumber 102866
Author Hu, Yu-Qian
Xiang, Kun
Tao, Sha-Sha
Zhang, Qin
Pan, Hai-Feng
Xu, Zhiwei
Wang, De-Guang
Wang, Xue-Rong
Li, Tian-Yu
Ding, Li-Hong
Ye, Dong-Qing
He, Yi-Sheng
Wu, Guo-Cui
Author_xml – sequence: 1
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  organization: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
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  givenname: Zhiwei
  surname: Xu
  fullname: Xu, Zhiwei
  organization: School of Public Health, Faculty of Medicine, University of Queensland, 288 Herston Road, Herston, QLD, 4006, Brisbane, Australia
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  givenname: Yu-Qian
  surname: Hu
  fullname: Hu, Yu-Qian
  organization: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
– sequence: 4
  givenname: Yi-Sheng
  surname: He
  fullname: He, Yi-Sheng
  organization: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
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  givenname: Guo-Cui
  surname: Wu
  fullname: Wu, Guo-Cui
  organization: School of Nursing, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
– sequence: 6
  givenname: Tian-Yu
  surname: Li
  fullname: Li, Tian-Yu
  organization: Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
– sequence: 7
  givenname: Xue-Rong
  surname: Wang
  fullname: Wang, Xue-Rong
  organization: Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
– sequence: 8
  givenname: Li-Hong
  surname: Ding
  fullname: Ding, Li-Hong
  organization: Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
– sequence: 9
  givenname: Qin
  surname: Zhang
  fullname: Zhang, Qin
  organization: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
– sequence: 10
  givenname: Sha-Sha
  surname: Tao
  fullname: Tao, Sha-Sha
  organization: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
– sequence: 11
  givenname: Dong-Qing
  surname: Ye
  fullname: Ye, Dong-Qing
  organization: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
– sequence: 12
  givenname: Hai-Feng
  surname: Pan
  fullname: Pan, Hai-Feng
  email: panhaifeng@ahmu.edu.cn
  organization: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
– sequence: 13
  givenname: De-Guang
  surname: Wang
  fullname: Wang, De-Guang
  email: wangdeguang@ahmu.edu.cn
  organization: Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
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Keywords Autoimmunity
Circadian clock genes
Inflammation
Circadian rhythm
Autoimmune diseases
Therapeutic target
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Snippet Circadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have...
AbstractCircadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes...
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SubjectTerms Allergy and Immunology
Autoimmune diseases
Autoimmunity
Circadian clock genes
Circadian rhythm
Inflammation
Therapeutic target
Title Circadian clock genes as promising therapeutic targets for autoimmune diseases
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