Defective interfering influenza A virus protects in vivo against disease caused by a heterologous influenza B virus

• Published in: Journal of general virology Vol. 92; no. 9; pp. 2122 - 2132
• Main Authors: Scott, Paul D, Meng, Bo, Marriott, Anthony C, Easton, Andrew J, Dimmock, Nigel J
• Format: Journal Article
• Language: English
• Published: Reading Society for General Microbiology 01.09.2011
• Subjects: Animals; Biological and medical sciences; cell culture; Cross Protection; Defective Viruses - immunology; Disease Models, Animal; Female; Fundamental and applied biological sciences. Psychology; genome; humans; Immunity, Innate; influenza; Influenza A virus - immunology; Influenza B virus; Influenza B virus - immunology; innate immunity; Interferon Type I - immunology; interferons; intranasal administration; Male; mechanism of action; Mice; Microbiology; Miscellaneous; Orthomyxoviridae Infections - prevention & control; Paramyxoviridae; pathogens; progeny; Rodent Diseases - prevention & control; Virology; viruses; Virus; Orthomyxoviridae; Influenzavirus A; Influenza A virus

Influenza A and B viruses are major human respiratory pathogens that contribute to the burden of seasonal influenza. They are both members of the family Orthomyxoviridae but do not interact genetically and are classified in different genera. Defective interfering (DI) influenza viruses have a major...